7,8-DHF (7,8-Dihydroxyflavone) is a naturally occurring flavonoid with possible cognition-enhancing properties. Its recent discovery has spurred research into its unique properties. Due to its low solubility and extensive first-pass metabolism, 7,8-DHF has poor oral bioavailability. However, it is able to cross the blood brain barrier effectively.
7,8-DHF is believed to directly bind the tropomyosin-related kinase B (TrkB) receptor, which is the endogenous receptor for BDNF (Brain Derived Neurotrophic Factor). BDNF can be thought of as “MiracleGro for the brain;” it is one of the main neurotrophic factors responsible for neurogenesis and increases dendritic outgrowth and density. By enhancing TrkB expression, it may be possible to increase the rate new synapses are formed, thus enhancing learning. Some researchers hypothesize that 7,8-DHF does not bind TrkB directly, but instead acts on an unknown pathway that results in the same end result--increased TrkB activity. 7,8-DHF is believed to have a similar degree of neurogenic activities as BDNF.
On top of its effects on neurogenesis, 7,8-DHF is also neuroprotective. It has antioxidant properties in the brain that are independent of its TrkB activity. While these mechanisms are not understood, it is believed to activate the Akt/PKB pathway.
Some animal studies indicate that 7,8-DHF may combat stress and boost mood. It is possible that it is more effective in repairing damaged, rather than healthy neurons and pathways. Anecdotal evidence suggests higher doses may provide an acute mood boost. Sublingual administration is recommended to avoid first-pass metabolism.
This product is 2 grams [0.07 oz] of pure 7,8-Dihydroxflavone, HPLC-verified at ≥98% purity in a transparent, reclosable glass jar with an integrated Safety Seal and Shrinkband.
Also included are the certificate of analysis for the individual 7,8-DHF batch and a 0.15cc measuring scoop. One rounded scoop contains approximately one serving of 40mg 7,8-Dihydroxyflavone.
More information on 7,8-DHF can be found at:
https://en.wikipedia.org/wiki/7,8-Dihydroxyflavone
https://examine.com/supplements/7-8-dihydroxyflavone/
