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How To Take Apigenin Extract (Matricaria Chamomilla) – 4 Top Questions Answered

Apigenin is a potent plant flavonoid that is widely present in fruits and vegetables and it is known to exhibit significant antioxidant activity. Among the thousands of known flavonoids, Apigenin along with quercetin, kaempferol, myricetin and luteolin are the five most abundant flavonoids in our diet.[1]

Apigenin is found particularly in high concentrations in plants such as celery, kumquats, onions, chamomile, parsley and oregano. [2]

Our Liftmode Apigenin supplement is derived Matricaria chamomilla (also known as chamomile), a flower belonging to the Asteraceae family. The chamomile extract as well as other Apigenin-containing herbs were used for centuries as functional foods and herbal remedies because of their stress-reducing, antiviral, antioxidant and anti-inflammatory properties.

In this article, we look at guidelines on taking Apigenin supplements, i.e. recommended dosages, side effects and important interactions with other herbs or medications. If you are looking for more details on the side effects and benefits of Apigenin, check out our blog posts or product description.

What Are Some Key Apigenin Extract Benefits?

Apigenin is an incredibly powerful compound with several health benefits.

Today, Apigenin is used to support a number of body functions. Some of the key therapeutic properties of Apigenin include:

  • Modulates inflammation and exhibits antioxidant effects, protecting the body from oxidative stress. [3]
  • Acts as a neuroprotective and cognitive enhancing agent. [4]
  • It may reduce feelings of stress through its positive impact on serotonin and dopamine.
  • Apigenin may support cardiovascular function and weight loss.

How Much Apigenin Extract (Matricaria chamomilla) to Take?

 Since Apigenin is a phytochemical that is present in most food sources, recommended dietary varies widely. In terms of Apigenin supplementation, there is no standard dose. In terms of general dosing, studies have shown Apigenin is most effective and safe in doses ranging from 200 mg to 1500 mg.

For more specific uses, studies have found the following doses to be safe and effective:

  • 200 mg/kg to 500 mg/kg of body weight per day taken for 15 days may significantly improve memory through its scavenging action on free radicals. [5]

 

  • 20mg/kg to 40 mg/kg of bodyweight taken once per day was shown to decrease stress through its modulation of neurotransmitters involved in mood (dopamine, noradrenalin and serotonin) as well as its upregulation of brain-derived neurotrophic factor (BDNF). [6]

 

  • 500 mg three times per day in a 12-week anxiety model found a significant reduction in symptoms of stress and an accompanied weight loss and reduction in blood pressure. [7]

 

  • 73 mg - 4.49 mg of daily parsley intake during a 2-week period showed an increase in glutathione reductase and superoxide dismutase, enzymes involved in liver detoxification. This indicates Apigenin has antioxidant and anti-inflammatory activity.[8]

Make sure to follow user guidelines on product labels. Do not exceed doses on packaging without medical supervision. High doses (100 mg/kg of bodyweight) are hepatotoxic. Consult your doctor before trying this supplement.

Is Apigenin Safe – Side effects and Drug Interactions

As for the safety of Apigenin supplements, reports have found Apigenin to have low toxicity and safe for long term use. [9] However, some may experience allergic reactions to this supplement. Matricaria chamomilla L. is a member of ragweed family of plants and therefore individuals with ragweed allergies can have allergic reactions such as skin irritations and in high doses can cause nausea or drowsiness. [10]

Another warning of Apigenin supplements is that it may cause liver toxicity in mice in high doses (100mg/kg of bodyweight). [11] In addition, Apigenin supplements may have mild blood-thinning effects and should therefore be avoided in high doses before surgery. [12]

Lastly, Apigenin may exert potent estrogenic effects. Women taking hormonal therapy replacement or with estrogen-dependent cancers should avoid taking this product. [13]

There is not sufficient data regarding the safety of Apigenin supplements on pregnant or breastfeeding women, or if it can be used by children. For this reason, please consult your doctor before trying this product.

In terms of interactions, Apigenin extract may interact with blood thinners, antiplatelet drugs, and aspirin. Apigenin may has inhibitory effects on acyclovir and adefovir. [14] 

Conclusion

To summarize, Apigenin is an incredible supplement for cognitive support, stress-reducer, and immune booster. It has been shown to reduce inflammation and boost antioxidant status and supports general health and well-being.

Given the fact that it supports relaxation and sleep, it can be consumed anytime of the day as it doesn’t interfere with circadian rhythms.  Studies suggest it is most effective and safe in doses ranging from 200 mg to 1500 mg daily.

Please consult your healthcare provider before taking this product if you are pregnant, breastfeeding, or have underlying health conditions. Apigenin interacts with blood thinning medications such as aspirin, and antiviral medications. It may also increase estrogen activity and should not be taken by individuals with estrogen dominant health conditions.

References

[1] Minqian Wang. Jenni Firrman.  LinShu Liu.  et al. (2019). ‘A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota’, BioMed Research International, vol. 2019, Article ID 7010467, 18 pages, 2019. https://doi.org/10.1155/2019/7010467

 

[2] S. Bhagwat, D. B. Haytowitz, and J. M. Holden. ‘USDA Database for the Flavonoid Content of Selected Foods’,  U.S. Department of Agriculture, pp. 1–156, 2011.

 

[3] Karamese M. Erol H.S. Albayrak M. et al. (2016). ‘Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study’, Immunopharmacology & Immunotoxicology, 38(3), pp.228-37. doi: 10.3109/08923973.2016.1173058. PMID: 27144896.

 

[4] Venigalla, M. Gyengesi, E. & Münch, G. (2015). ‘Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease’, Neural regeneration research10(8), 1181–1185. https://doi.org/10.4103/1673-5374.162686

 

[5] Alibabaei Z. Rabiei Z. Rahnama S. et al. (2014). ‘Matricaria chamomilla extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine’, Biomedicine and Aging Pathology, 4:355–360. doi: 10.1016/j.biomag.2014.07.003.

 

[6] Amsterdam J.D. Shults J. Soeller I. et al. (2012). ‘Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study’ Altern Ther Health Me, 18(5):44-9. PMID: 22894890; PMCID: PMC3600408.

 

[7] Mao J.J. Xie S.X. Keefe J.R. et al. (2016). ‘Amsterdam J.D. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial’, Phytomedicine,   (23), pp. 1735–1742. doi: 0.1016/j.phymed.2016.10.012.

 

[8] Nielsen S.E. Young J.F. Daneshvar B. et al. (2016). ‘Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects’, British Journal of Nutrition 81(6), pp.447-55. doi: 10.1017/s000711459900080x. PMID: 10615220.

 

[9] Mao J.J. Xie S.X. Keefe J.R. et al. (2016). ‘Amsterdam J.D. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder, op. cit. 7.

 

[10] A. Vogiatzoglou A. A. Mulligan  M. A. Lentjes et al., “Flavonoid Intake in European Adults (18 to 64 Years),” PLoS ONE, vol. 10, no. 5, p. e0128132, 2015.

 

[11] Singh, P. Mishra, S. K. Noel, S. Sharma, S. & Rath, S. K. (2012). ‘Acute exposure of apigenin induces hepatotoxicity in Swiss mice’, PloS one7(2), e31964. https://doi.org/10.1371/journal.pone.0031964

 

[12] Navarro-Núñez L, Lozano ML, Palomo M, Martínez C, Vicente V, Castillo J, Benavente-García O, Diaz-Ricart M, Escolar G, Rivera J. Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. J Agric Food Chem. 2008 May 14;56(9):2970-6. doi: 10.1021/jf0723209. Epub 2008 Apr 15. PMID: 18410117.

 

[13] Barlas N. Özer S. Karabulut G. (2014). ‘The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar albino rats’, Toxicology Lett.  226(1), pp.35-42. doi: 10.1016/j.toxlet.2014.01.030. Epub 2014 Jan 30. PMID: 24487097.

 

[14] Wu T. Li H. Chen J. et al. (2017). ‘Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1)’, Pharmacology Rep, 69(6), pp. 1254-1262. doi: 10.1016/j.pharep.2017.06.012. Epub 2017 Jun 27. PMID: 29128807.