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How to Take DL-Phenylalanine - The Ultimate Guide!

DL-Phenylalanine is a combination of two forms of Phenylalanine. D-Phenylalanine is a laboratory-made substance that has been studied for pain relief. L-Phenylalanine is a naturally occurring essential amino acid. L-Phenylalanine has a number of great health-promoting benefits and may help reduce feelings of stress.

The combination of the two, DL-Phenylalanine, allows you to experience the benefits of both supplements. DL-Phenylalanine usually contains equal amounts of D-Phenylalanine and L-Phenylalanine. In this article, we’ll explore how you can take DL-Phenylalanine for optimum health.

Young man studying with DL-Phenyalanine, happy

Why take DL-Phenylalanine?

DL-Phenylalanine is a combination of D-Phenylalanine and L-Phenylalanine, two different forms of Phenylalanine. This gives you the benefits of both substances, in combination.

D-Phenylalanine is a laboratory-made substance that has been studied for potential pain-relief effects. It has great effects and is especially useful in supporting your natural pain-relief system.[1]

L-Phenylalanine is an essential amino acid and is required for your body to function correctly. L-Phenylalanine deficiency is linked to lowered mood and feelings of stress.[2] Higher doses of L-Phenylalanine may have the potential to improve your mood and focus.[3]

However, the effect is the exact opposite for a few number of people who suffer from a rare disorder called Phenylketonuria. In this case, supplementing with DL-Phenylalanine is a bad idea as it directly decreases mood and can cause negative health effects.[4]

How to take DL-Phenylalanine?

liftmode's supplements for pain Liftmode's DL-Phenylalanine, 99% purity

You can take DL-Phenylalanine in a number of different ways. The salt form (DL-Phenylalanine HCL) is soluble in water.[5] Some forms are only soluble in warm or hot water. Most people enjoy the slightly sweet taste.

However, if you’d rather not taste it, another way to take DL-Phenylalanine is to use a well-measured scoop in a capsule. This means that you can get the benefits of DL-Phenylalanine without the taste.

We’d also recommend adding DL-Phenylalanine to a healthy fruit smoothie.


How much DL-Phenylalanine is too much?

The recommended dosage of DL-Phenylalanine is around 100 – 500 mg per day. Exceeding this dosage may cause negative side effects. Does that are higher than 5000 mg can cause nerve damage.[6]


Are there DL-Phenylalanine side effects?

girl with sunflower, happy DL-Phenylalanine is know to boost your mood

The studies that have been done on DL-Phenylalanine so far have indicated that most people are able to tolerate it without experiencing any negative side effects. It’s important to realize that there is still a need for more in-depth research about DL-Phenylalanine and how it works.[7]

WebMD simply states that you should consult your pharmacist.[8] In our research, we haven’t seen any indication of negative adverse effects at the recommended dosage.

Researchers have not noted any negative dangerous side effects for either L-Phenylalanine nor D-Phenylalanine alone. So, it follows that DL-Phenylalanine is a very safe dietary supplement.[9]



In conclusion, there are a number of different ways that you can use DL-Phenylalanine to improve your mood and focus. DL-Phenylalanine is best taken at a dosage of 100 – 500mg per day and not ever exceeding 5000 mg per day.

It is a little soluble in water and can be taken in a glass of hot water. You can also take DL-Phenylalanine in a healthy smoothie or in capsules. DL-Phenylalanine is a dietary supplement that offers a combination of two forms of the amino acid Phenylalanine.




[1] Analgesic effectiveness of D-phenylalanine in chronic pain patients, NE Walsh et al., Arch Phys Med Rehabil. 1986 Jul;67(7):436-9.

[2] Effects on mood of acute phenylalanine/tyrosine depletion in healthy women, M Leyton et al., Neuropsychopharmacology. 2000 Jan;22(1):52-63.

[3] L-Phenylalanine, PubChem, Open Chemistry Database, retrieved on 8 December, 2016

[4] High phenylalanine levels directly affect mood and sustained attention in adults with phenylketonuria: a randomised, double-blind, placebo-controlled, crossover trial, AE ten Hoedt et al., J Inherit Metab Dis. 2011 Feb;34(1):165-71.


[5] Phenylalanine, PubChem, Open Chemistry Database, retrieved on December 8, 2016

[6] Phenylalanine, WebMD Vitamins and Supplements, retrieved on December 8, 2016

[7] DL-phenylalanine versus imipramine: a double-blind controlled study, H Beckmann et al., Arch Psychiatr Nervenkr (1970). 1979 Jul 4;227(1):49-58.

[8] DL-Phenylalanine, WebMD.com, retrieved on December 8, 2016

[9] Phenylalanine, University of Maryland Medical Center online, retrieved on December 8, 2016