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Oleamide High? – Top 6 Verified Benefits of The Endocannabinoid

Many people on the internet are searching for questions about the Oleamide high. In this article, we explore six of the top benefits of this amazing supplement that have been verified by science.

Research has shown that Oleamide binds to two types of receptors that are known to produce psychoactive effects. Scientists have also found that Oleamide helps to improve learning and focus while producing calming and relaxing effects.

It may well be that there is such a thing as an Oleamide high. However, this would be described by most people as more of a calming experience at higher doses.

sitting in a red chair, Oleamide high Many people search for the 'Oleamide high' online - this supplement is known to improve sleep and boost mood

6 Scientifically Verified Oleamide Benefits

People on the internet are talking about the so-called ‘Oleamide high’. This interesting compound is especially functional in aiding with sleep and helping to promote relaxation. However, researchers have found that it also interacts with certain receptors in your brain that may cause psychoactive effects.

For example, Oleamide is known to interact with cannabinoid receptors as well as certain serotonin receptors. Some people argue that this can be justified in claiming that there is such a thing as an ‘Oleamide high’. However, this has not yet been scientifically verified.

Synapses on Oleamide Oleamide binds to receptors in your brain to produce its effects

Some people have experienced what they would call an Oleamide high and have posted these experiences online. To read more about them, take a look at our Oleamide review section at the end of this page.

 

Interestingly, this fascinating compound is produced naturally in our bodies. This is why scientists have termed it an endocannabinoid compound. Oleamide is a molecule that is produced from Oleic acid (found in olive oil). It is also found in a number of plant species, including some plants that were used in Traditional Chinese Medicine (TCM) to help promote sleep. [1]

Oleamide concentrations are especially high in your brain during periods of sleep deprivation. In fact, not sleeping for just 6 hours more than usual results in a 3-4 fold increase in the concentration of Oleamide in your brain! [2]

Below, we explore the top 6 scientifically-verified benefits of Oleamide. These have been published in clinical research journals and often contain data from studies with humans.

 

However, there is a need for further investigation into many of the effects on humans for a more thorough understanding of how this wonderful sleep-enhancing supplement works.

 

1.    Potent Mood-Boost

Oleamide activates serotonin receptors to create a mood-boosting effect. [3] Interestingly, the serotonin receptors that are activated by Oleamide are the same receptor subtypes that are activated by a class of biochemicals known as psychedelics.

Specifically, these are the same receptors that activated by substances like psilocybin, mescaline, and other psychoactive compounds. [4] It is possible that Oleamide acts like a naturally-produced psychedelic compound – increasing creativity and allowing for different thought patterns to be expressed.

** For science nerds: Oleamide works best on 5-HT2A, 5-HT2C, and 5-HT1A receptors. Although Oleamide increases the action of these receptors, it does not appear to influence serotonin-binding. The proposed mechanism of action is through increased post-receptor signaling, independent of serotonin binding. [5]

 

While these receptor subtypes are associated with psychoactive effects, they are also known to improve mood. The 5-HT2A and 5-HT1A receptors are especially relevant to mood and have been used as targets in clinical studies on mood disorders. Activating these receptor subtypes – as Oleamide does – is known to support a healthy mood. [6]

Happy old man on Oleamide Oleamide is known to produce potent mood-boosting effects through its interactions with the serotonin receptors

2.    Relaxing Effects

Oleamide also works by affecting the GABA-receptors in your brain. GABA-receptors are targets for sedative and anxiolytic compounds because of their natural relaxing and tranquilizing effects on your body. [7]

The GABA hormone is known as your body’s natural depressant neurotransmitter. This means that it depresses signals from the Central Nervous System, resulting in improved relaxation. Compounds that activate GABA-receptors have a similar tranquilizing effect.

Oleamide has been shown to activate GABA receptors at even at extremely low concentrations. GABA receptor activity is increased by an average of around 220% by moderate doses of Oleamide. This increased activity is thought to result in a highly noticeable mood change including stress-relief and relaxation. [8]

 

3.    Improves Sleep

woman sleeping on Oleamidehttps://liftmode.com/calming/oleamide.html Oleamide is grat for helping with sleep

Oleamide is thought to act more as a synergist with GABA receptors than a direct GABA-receptor activator. It does not alter the way that GABA binds to receptors, even at high doses. [9]

Regardless of this, Oleamide has been shown to have positive effects on sleep. Oleamide supplements appear to be able to reduce the time to fall asleep as well as improving the quality of sleep.[10]

At fairly high doses, Oleamide is able to reduce your motor-coordination. It is not recommended to drive or operate machinery while using Oleamide, as it can cause drowsiness/sleepiness at high doses. [11]

 

4.    May Help to Improve Learning

On the one hand, a great benefit of Oleamide supplements is that they may have the capacity to improve learning abilities. This has been shown in animal studies but is yet to be conclusively studied in humans. [12]

However, the unique interaction with serotonin receptors indicates that Oleamide may have the ability to alter your thinking processes – allowing more creative and ‘out-the-box’ thinking. This has been confirmed in animal studies, where Oleamide in moderate doses has shown an improvement in learning. [13]

On the other hand, studies have shown that Oleamide may have a slight temporary negative impact on short-term memory. These effects diminish after the Oleamide is fully metabolized – within 24 hours. It is thought to be an outcome of Oleamide’s interactions with the cannaboid receptors in your brain. [14]

So, although Oleamide may have the ability to improve learning and focus, it may also slightly impair short-term memory for the duration of its effects. For more information on this, read through our article on supplements that may boost pineal gland function!

Girl learning lights flickering after taking Oleamide Studies suggest that Oleamide may help with learning

5.    Increased Appetite

Animal studies have shown that mild to moderate doses of Oleamide have a positive effect on stimulating appetite. Researchers have proposed that the increased appetite is linked to Oleamide’s effects on cannaboid receptors. [15]

For more information on how Oleamide works check out our interesting article with 5 Easy to to Understand Concepts on this great supplement!

6.    Psychoactive Effects

One important aspect of Oleamide is that it binds to cannabinoid receptors in your brain. These are the same receptors that the compounds in certain psychoactive plants bind to when smoked or eaten.

Importantly, Oleamide interacts with both the CB1 and CB2 cannabinoid receptors in your brain. These receptors have very different functions, both of which may be considered to be beneficial.

On the one hand, the CB1 receptor is considered to be the primary receptor for all cannabinoid compounds and mediates the psychoactive experience felt by users of plants containing chemicals like THC and other natural cannabinoids.

 

Studies have shown that Oleamide has significant effects on the CB1 receptor, at high doses. As a result, scientists have proposed that Oleamide is a type of molecule called an endocannabinoid – referring to a cannabinoid compound produced within your body. [16]

On the other hand, the CB2 receptor is involved in your brain’s anti-inflammatory action. Scientists have shown that by binding to this receptor, Oleamide is able to exert powerful anti-inflammatory effects, especially in your brain. This is thought to help protect your brain from stress and toxins. [17]

Furthermore, Oleamide has been shown to reduce inflammation through other mechanisms of action in your body. A 2010 study published in the Journal of Neuroscience Letters indicated that Oleamide was able to reduce the number of inflammatory markers both in the brain and throughout the rest of the body. [18]

Sleeping in the clouds, Oleamide high Oleamide is great for helping with sleep and is thought to produce some psychoactive effects at higher doses

How Do People Take Oleamide?

Oleamide dosage varies significantly. The recommended dosage is between 50 – 200 mg per day. However, some people do take a slightly high dosage for more pronounced effects. For more information about how to take Oleamide check out our interesting article here!

In animal studies, scientists have shown that the Oleamide LD-50 (the dosage at which half of the population are killed) is greater than 1000mg/kg bodyweight. [19]

Oleamide is rapidly metabolized in your body and has a short half-life. However, there is still a lack of research into the maximum dosage for humans. We urge users to stick to the recommended daily dosage.

Oleamide Experiences: User Reviews Online

We've complied a few user reviews on Oleamide from the internet. For more reviews, check out our article on Oleamide reviews from our Blog!

1.Buttery Placidity

 It was calming, enhanced my perceptivity and appreciation of music (which I love), as well as slaying the dread I often feel prior to engaging in mundane redundant tasks (e. g. hand-washing dishes). Overall, it had a subtle yet succinctly tangible effect on me.” – Review by Mick, on Liftmode.com [20]

 

2. Great for Sleep and More

This product has definitely helped my sleep, and seemed to help my back pain related to daily work as well, although I know that isn't stated as one of the uses. I find it easiest to take by simply putting it directly on my tongue, as it has no terrible flavor like some of the other products here. I'm constantly impressed by the quality of service and products from this company. The amount of information and attention to detail that is paid is beyond compare in my opinion.” – Review by Cassiel, on Amazon.com [21]

 

3. Oleamide, review, and thoughts

 Oleamide is still working for me at doses of 200mg. A note about tolerance: Oleamide almost gave me a c******* like "high" the first time I took it while every other time it just gives me sedation and helps sleep. Sometimes I think it is not working, but I always fall asleep quickly after sublingual administration. Even if you think it’s not working, close your eyes, let your head hit the pillow and try to let sleep take you for an hour. You might be pleasantly surprised.” – Review by Dmitri357 on Reddit.com [22]

close up of a woman hands typing in a laptop in a coffee shop terrace in the street Most people who've written about the Oleamide high have left anonymous reviews online

Conclusion – Is Oleamide An Endocannabinoid?

Oleamide is a great supplement for promoting healthy sleep and relaxation. Some of the top benefits of Oleamide include a potent mood-boost and calming effects along with improved sleep. Studies have shown that Oleamide may also help improve learning but may also have a temporary negative effect on short-term memory during the duration of the effects. [23]

Oleamide 50 grams Liftmode's Oleamide: 99%+ purity

Studies have shown that Oleamide binds to serotonin receptors and cannabinoid receptors that are associated with psychoactive experiences. These may explain the improved mood and the increased appetite that people experience when using Oleamide. Furthermore, it is possible that the binding to cannabinoid receptors is what triggers the appetite increase associated with Oleamide supplements.

At this point, it is difficult to say whether the Oleamide high is real, apart from the user experiences that people have posted online. These seem to indicate that it has the potential to produce some psychoactive effects at high doses. However, the most pronounced benefits of Oleamide are still the improvements in sleep quality and the related mood-boost and relaxing effects.

*** For science nerds: Some scientists are still unsure as to whether or not Oleamide can be classified as an endocannabinoid. This is because the studies which showed it binding to psychoactive cannabinoid receptors – CB1 receptors – used fairly high dosages and have not been replicated in humans.

References:

[1] HJ Heo et al., “Effects of oleamide on choline acetyltransferase and cognitive activities”, Biosci Biotechnol Biochem. 2003 Jun;67(6):1284-91.

[2] AS Basile et al., “Characterization of the hypnotic properties of oleamide”, Neuroreport. 1999 Apr 6;10(5):947-51.

[3] EA Thomas et al., “Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide”, Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 14115–14119, December 1997, Pharmacology

[4] CT Egan et al., “Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors”, Psychopharmacology (Berl). 1998 Apr;136(4):409-14.

[5] X Guan et al.,“The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells”, J Cell Biol. 1997 Dec 29;139(7):1785-92.

[6] P Celada et al., “The therapeutic role of 5-HT1A and 5-HT2A receptors in depression”, J Psychiatry Neurosci. 2004 Jul; 29(4): 252–265.

[7] AM Abdou et al., “Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans”, Biofactors. 2006;26(3):201-8

[8] L Coyne et al., “The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro” Br J Pharmacol. 2002 Apr; 135(8): 1977–1987

[9] JP Huidobro-Toro, RA Harris, “Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors”, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8078-82.

[10] JY Yang et al., “The serotonergic system may be involved in the sleep-inducing action of oleamide in rats”, Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):457-62. Epub 2003 Nov 13.

[11] I Fedorova et al., “Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems”, J Pharmacol Exp Ther. 2001 Oct;299(1):332-42.

[12] MA Akanmu et al., “Neuropharmacological effects of oleamide in male and female mice”, Behav Brain Res. 2007 Aug 22;182(1):88-94. Epub 2007 May 22.

[13] G Lees, A Dougalis et al., “Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro”, Brain Res. 2004 Jan 30;997(1):1-14.

[14] E Murillo-Rodríguez et al., “Oleamide modulates memory in rats”, Neurosci Lett. 2001 Nov 2;313(1-2):61-4.

[15] D Martínez-González et al., “Oleamide and anandamide effects on food intake and sexual behavior of rats”, Neurosci Lett. 2004 Jun 24;364(1):1-6.

[16] CJ Fowler, “Oleamide: a member of the endocannabinoid family?”, Br J Pharmacol. 2004 Jan; 141(2): 195–196.

[17] J Fernández-Ruiz et al., “Cannabinoid CB2 receptor: a new target for controlling neural cell survival?”, Trends Pharmacol Sci. 2007 Jan;28(1):39-45. Epub 2006 Dec 1.

[18] YT Oh et al., “Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells”, Neurosci Lett. 2010 May 3;474(3):148-53.

[19]Oleamide DEA, N,N-bis(2-hydroxyethyl)-(Z)-9-octadecenamide”, facts sheet from The Good Scent Company, available online, accessed May 11, 2017

[20]Buttery Placidity” Review by Mick, Liftmode.com, accessed May 11, 2017

[21]Great for Sleep and More”, Oleamide review by Cassiel on Amazon.com, accessed May 11, 2017

[22]Oleamide, review and thoughts” Oleamide review by Dmitri357 on Reddit.com, r/Insomnia, available online, accessed May 11, 2017

[23]Oleamide”, Examine.com, accessed May 11, 2017