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What do people use Oleamide for? Top 4 Benefits of Oleamide!

Oleamide is an endogenous sleep-producing lipid. People use oleamide for a number of effects, including promoting healthy sleep. Oleamide occurs in high quantities during sleep deprivation. Interestingly, oleamide dietary supplements are sometimes manufactured from olive oil derivatives. It is great for helping with falling asleep, improving your mood, and increases your appetite.


In this article, we’ll examine the top benefits of oleamide. Oleamide interacts with certain receptors in your brain called GABA receptors. At higher doses, oleamide interacts with cannabinoid receptors. Some people claim that higher doses of oleamide produce strong psychoactive effects.

Red haired woman sleeping after taking Oleamide You can use Oleamide for promoting healthy sleep and rest

Top 4 Oleamide benefits

1. Promotes a calm, relaxed state

Oleamide is very effective at binding to GABA-A receptors.[1] People use oleamide for a calm, tranquil, and relaxed state of mind. GABA is your body’s inhibitory transmitter, slowing down ‘messages’ from your body’s central nervous system.

Oleamide 50 grams Liftmode's Oleamide: 99%+ purity

Oleamide mimics GABA, and your body naturally produces oleamide to help you fall asleep.[2]  Many people claim that they feel very ‘chilled out’ on high doses of oleamide. This extra feeling of relaxation may be due to Oleamide’s interaction with certain cannabinoid receptors.[3] These receptors are the targets of a certain psychoactive plant with varying legal status across the US.


2. Oleamide for appetite and improved mood

Animal studies have found that oleamide increases appetite for roughly 3 hours after using it. Rats given oleamide ate significantly more food than those who weren’t given oleamide.[4] These findings are further backed up by anecdotal evidence on various online forums. The mechanism is thought to be related to oleamide’s ability to bind to cannabinoid receptors.

Scientists have also shown that oleamide interacts with serotonin receptors.[5] We know that serotonin influences your mood. Your mood increases with oleamide use because of how it affects your serotonin receptors.


3. Promotes healthy sleep

You can use Oleamide to promote healthy sleep. Oleamide plays a role in promoting relaxation and calm before sleep. The biochemical mechanism that oleamide uses to promote sleep is very complex. The end result is that it slows electrochemical ‘signals’ in your brain prior to falling asleep.[6]

It is not recommended to drive or operate heavy machinery while using oleamide. Using oleamide for sleep benefits temporarily slows your response time and may reduce your coordination.[7]


4. Anti-inflammatory

Oleamide for inflammation Oleamide is a great anti-inflammatory substance

Various in-depth studies have examined the effects of oleamide for inflammation. Scientists have found that oleamide is a potent anti-inflammatory compound, and is particularly effective at reducing inflammation in nerve cells and in your brain.[8]


This is important because it means that oleamide helps to protect your brain from inflammation and stress.


How much Oleamide to take?

The recommended Oleamide supplement dosage has not yet been determined for humans. However, most online user reviews and experiences note using a dosage of around 50 – 200mg daily.

Side effects of oleamide have not yet been studied extensively. Oleamide may interact with prescription medication. It is recommended to consult your physician if you are using prescription medication or have an underlying medical condition.



Oleamide is a wonderful and natural substance that is produced in your brain prior to sleep. It has a number of great benefits. Taking an oleamide supplement can improve your sleep patterns, promote rest and relaxation, help to calm you, and improve your appetite. Oleamide is best taken in the evening or prior to sleep. It may temporarily reduce your motor coordination and short-term memory.

Old couple sitting on the beach Oleamide is great for relaxation!


[1] Stereoselective modulatory actions of oleamide on GABA(A) receptors and voltage-gated Na(+) channels in vitro: a putative endogenous ligand for depressant drug sites in CNS, B Vernon et al., Br J Pharmacol. 2000 Jan;129(2):283-90, available from http://www.ncbi.nlm.nih.gov/pubmed/10694234

[2] The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro, L. Coyne et al., Br J Pharmacol. 2002 Apr; 135(8): 1977–1987, doi:  10.1038, available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573315/

[3] Oleamide: a member of the endocannabinoid family? C.J. Fowler, Br J Pharmacol. 2004 Jan; 141(2): 195–196, Published online 2003 Dec 22. doi:  10.1038, available from


[4] Oleamide and anandamide effects on food intake and sexual behavior of rats, Martínez-González D et al., Neurosci Lett. 2004 Jun 24;364(1):1-6, available from http://www.ncbi.nlm.nih.gov/pubmed/15193744

[5] Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide, E.A. Thomas et al., Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 14115–14119, December 1997, Pharmacology, available from http://www.pnas.org/content/94/25/14115.full.pdf

[6] The Sleep-inducing Lipid Oleamide Deconvolutes Gap Junction Communication and Calcium Wave Transmission in Glial Cells, G Xiaojun et al., J Cell Biol. 1997 Dec 29; 139(7): 1785–1792, available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132638/

[7] Characterization of the hypnotic properties of oleamide, AS Basile et al., Neuroreport. 1999 Apr 6;10(5):947-51, available from http://www.ncbi.nlm.nih.gov/pubmed/10321465

[8] Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells, YT Oh et al., Neurosci Lett. 2010 May 3;474(3):148-53. doi: 10.1016, available from http://www.ncbi.nlm.nih.gov/pubmed/20298753