Phenylethylamine is a stimulating compound found in a number of food sources and produced naturally in our bodies. Phenylethylamine (PEA) helps to boost your mood, energy, and focus. When people talk about the ‘runner’s high’ they’re often talking about PEA.
Phenylethylamine is broken down very rapidly by enzymes and its effects only last for around 1-2 hours. Taking PEA with some MAO-B inhibitors like Hordenine helps to prolong the effects for a few more hours.
Phenylethylamine is a stimulant but is considered safe because of how quickly its broken down. The common PEA dosage is around 500 – 1500 mg daily.
Phenylethylamine Effects and Benefits
Firstly, Phenylethylamine is a strong stimulant. It influences receptors in your brain that respond to ‘energizing’ hormones. So, PEA makes your brain more responsive to hormones like epinephrine and norepinephrine. We call these the fight-or-flight hormones – ancient hormones found in all animals that make you much more energized.
Secondly, PEA creates a feeling called the ‘runner’s high’. It’s found in dark chocolate and red wine and your body creates lots of it after exercising. PEA binds to receptors called trace amine receptors. These are the same receptors that many psychedelics bind to.
Thirdly, phenylethylamine increases serotonin and dopamine, the ‘feel-good’ hormones. The effect is a powerful mood boost!
Lastly, phenylethylamine is great at improving focus and concentration. This is great for people with ADD or who need a little more focus. It’s also good for older people. As we get older, the number of brain chemicals called catecholamines reduces, causing lower energy and mood. PEA helps to increase catecholamines and restore mood and energy.
Phenylethylamine and Hordenine: A great relationship
Your brain metabolizes (breaks down) Phenylethylamine very quickly. So, the effects only last for around 1-2 hours. PEA is broken down by enzymes called MAOs. If you take PEA along with natural MAO inhibitors the effects are able to last for much longer. MAO-A inhibitors can be dangerous when you combine them with stimulants.
MAO-B inhibitors are much safer and produce much the same effects. Hordenine is a common MAO-B inhibitor with a host of other benefits. Taking Phenylethylamine with Hordenine increases the effects of both and allows PEA’s effects to last for much longer. However, this stack may cause some side effects and must be used responsibly. 
Other natural MAO inhibitors that you could take with Phenylethylamine include:
- Syrian Rue (MAO-A inhibitor)
There aren’t many studies into the best dosages of phenylethylamine. Since it is produced in our bodies naturally and broken down very rapidly, it’s quite hard to conduct studies on PEA supplements. Animal tests using Phenylethylamine dosages of between 1 – 40 mg / kg bodyweight showed positive effects.
The receptors that PEA effects work slightly differently in animals than in humans. Most users opt for a Phenylethylamine dosage of around 100 – 500 mg once to three times daily.
Phenylethylamine Side Effects
Phenylethylamine is a strong stimulant. Side effects of stimulants include irritability and restlessness. It can also cause increased heart rate. Taking PEA with MAO inhibitors prolong the effects and may increase its side effects.
If you want to increase the length of the PEA experience, you’d be better off taking PEA with Hordenine. Hordenine is an MAO-B substrate, which is safer than taking MAO inhibitors.
Phenylethylamine is a powerful but natural stimulant. You’ll get an increase in
energy and focus as well as a major mood boost. Phenylethylamine on its own is a fast-paced substance. You can prolong the effects of this wonderful energizing compound by including Hordenine in your stack.
 Phenylethylamine, Examine.com, available from https://examine.com/supplements/phenylethylamine/, retrieved on July 18, 2016
 Meredith Irsfeld,* Matthew Spadafore, and Dr. Birgit M. Prüß, β-phenylethylamine, a small molecule with a large impact, Webmedcentral. Author manuscript; available in PMC 2014 Jan 28, available from
effects to last for much longer. both and allows PEA'ebenefits. Taking Phenylethylamine with hordening h the same effects. Horhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904499/
 A Szabo, E Billett, J Turner, Phenylethylamine, a possible link to the antidepressant effects of exercise?, Br J Sports Med 2001;35:342-343 doi:10.1136/bjsm.35.5.342, available from http://bjsm.bmj.com/content/35/5/342.full
 M Murata et al., Effect of beta-phenylethylamine on extracellular concentrations of dopamine in the nucleus accumbens and prefrontal cortex., Brain Res. 2009 May 7;1269:40-6. doi: 10.1016/j.brainres.2009.03.002. Epub 2009 Mar 11, available from
 Mesfioui A, Effects of amphetamine and phenylethylamine on catecholamine release in the glomerular layer of the rat olfactory bulb, Biol Signals Recept. 1998 Jul-Aug;7(4):235-43, available from http://www.ncbi.nlm.nih.gov/pubmed/9730583
 Yang HY, Neff NH, Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain, J Pharmacol Exp Ther. 1973 Nov;187(2):365-71, available from
 Barwell CJ et al, Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat, J Pharm Pharmacol. 1989 Jun;41(6):421-3, available from
 Janet Contursi, Common Herbs With MAO Inhibitor Activity, August 2013, LiveStrong.com, available from
 CJ Barwell et al, Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat., J Pharm Pharmacol. 1989 Jun;41(6):421-3, available from
 Phenylethylamine (PEA) experiences and safety, thread on BlueLight.org, available from http://www.bluelight.org/vb/threads/388413-Phenylethylamine-(PEA)-experiences-and-safety, retrieved on July 18, 2016
 Phenylethylamine Side Effects, WebMD.com, available from http://www.webmd.com/vitamins-supplements/ingredientmono-1274-phenethylamine.aspx?activeingredientid=1274&activeingredientname=phenethylamine, retrieved on July 18, 2016