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How to take Oleamide for Relaxation: Top Tips

Oleamide is found naturally in all animals and helps to induce sleep. Scientists have found that oleamide helps to produce good REM sleep cycles, at higher doses. At lower doses, oleamide is a great calming and relaxing supplement.

People often take oleamide to reduce stress and anxiety. At higher doses, oleamide begins to interact with your cannabinoid receptors, further improving mood and acting as a mildly psychoactive supplement.

In this article, we’ll examine the best ways to take oleamide. We examine three of the top benefits of oleamide and take a look at oleamide side effects.

man leaning back, chilled on oleamide Many users take oleamide for a calm, relaxed state

What does Oleamide do?


1.    Relaxation and calming

Firstly, Oleamide is highly effective at promoting a calm, relaxed state. You can take oleamide to help with reducing stress and anxiety, and inducing a peaceful mindset.

relaxed woman listening to music Oleamide is great for relaxation and calming

The great calming effects of oleamide are because of how it interacts with your brain’s GABA receptors.[1] Oleamide also plays a role in your serotonin receptors, greatly improving your mood.[2]

At higher doses, oleamide interacts with your cannabinoid receptors.[3] Some people have reported mild psychoactive effects when they take oleamide at a higher dose.


2.    Improves sleep

Secondly, you can take oleamide to improve your sleeping patterns. Oleamide is made naturally in all animals to help with the process of falling asleep.[4] When you’re lacking sleep, oleamide begins to occur in especially high concentrations.

The exact mechanism by which oleamide aids in sleep is still under debate. It appears that the way it affects your GABA receptors has a lot to do with this.


3.    Protects your brain

Finally, many people who take oleamide aren’t fully aware of how good it is at protecting their brain.[5] A number of studies have shown that oleamide is highly effective at reducing ‘neuroinflammation’ – inflammation of your brain.

Neuroinflammation is involved in many diseases including Alzheimer’s and dementia. Also, due to unhealthy diets and inactive lifestyles, many people suffer from chronic inflammation which is dangerous.


The Best ways to take Oleamide

Proper recommended dosages haven’t yet been determined for oleamide. However, most people tend to use oleamide doses of around 50 – 200 mg daily.

Oleamide is a lipid, so it’s not soluble in water. One method to take oleamide is to just take the powder as is, under your tongue. Another possible method is to use empty capsules and fill them with well-measured oleamide powder, and then take one or two capsules prior to sleep.

Oleamide 50 grams Liftmode's Oleamide: 99%+ purity

Finally, you could also dissolve oleamide into a high-fat substance like hot milk or butter, and add this to a cup of tea or hot chocolate. Or simply add some oleamide to a delicious healthy smoothie!

Oleamide is best taken an hour or so before going to sleep. You can also use oleamide on a day when you’d like to just relax. So, hit up the couch and watch some movies or just chill on the beach all day!


Oleamide Side Effects: Safety first!

Again, the side effects of oleamide in humans haven’t been studied yet. However, this wonderful lipid is produced naturally by all animals in response to sleep signals.

human brain, x-ray illuminated Oleamide helps protect your brain from inflammation

Over millions of years, your human brain and body have evolved complex and intricate mechanisms to remove excess oleamide before negative effects occur.

Still, as with all dietary supplements, it is possible you may experience an allergy to oleamide. Oleamide is also known to make you slightly drowsy and may impair your motor functions at higher doses.[6] It’s not recommended to drive or operate heavy machinery, especially on higher doses of oleamide.


Oleamide user review

“Oleamide is interesting, in high doses, it’s relaxing and gave a stoned feeling similar to c******, it also made me a little dizzy but not in a bad way. In lower doses it gives you mild relaxation, helping somewhat with anxiety and tension. Since its from olive oil I would assume it would also possess properties beneficial to overall health but I'm not sure as I could not find much information about Oleamide on its own.  I would recommend it for sleep, relaxation, and muscle tension and of course with Liftmode you get the best quality for the best price and the best service!!” – LiftMode user review



Oleamide can be taken under your tongue, in a capsule, or dissolved in a high-fat substance like milk, honey, or butter. You can also take oleamide powder in a healthy smoothie! The recommended dosage for oleamide is around 50 – 200 mg.




[1] The Hypnotic Actions of the Fatty Acid Amide, Oleamide, W.B. Medelson and A.S. Basile, Neuropsychopharmacology (2001) 25, S36–S39. doi:10.1016, available from http://www.nature.com/npp/journal/v25/n1s/full/1395784a.html

[2] The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus, EA Thomas et al., J Neurochem. 1999 Jun;72(6):2370-8, available from http://www.ncbi.nlm.nih.gov/pubmed/10349846

[3] Oleamide: a member of the endocannabinoid family?, C.J. Fowler, Br J Pharmacol. 2004 Jan; 141(2): 195–196, Published online 2003 Dec 22. doi:  10.1038, available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574195/

[4] Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules, DL Boger et al., Curr Pharm Des. 1998 Aug;4(4):303-14, available from http://www.ncbi.nlm.nih.gov/pubmed/10197045

[5] Oleamide suppresses lipopolysaccharide-induced expression of iNOS and COX-2 through inhibition of NF-kappaB activation in BV2 murine microglial cells, YT Oh et al., Neurosci Lett. 2010 May 3;474(3):148-53. doi: 10.1016, available from http://www.ncbi.nlm.nih.gov/pubmed/20298753

[6] Oleamide, Examine.com, available from https://examine.com/supplements/oleamide/