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Baicalin with stacks! Top 5 supplement stacks

Baicalin is known to many as an all-round health-promoting supplement that aids in healthy sleep and has potent antioxidant and anti-inflammatory effects. In fact, baicalin is so powerful that most people chose to take it as is. If you’re interested in learning more of the effects of a baicalin supplement, please read through our product description.


In this article, we outline 5 of the most common baicalain stacks. Baicalin can be used with a number of dietary supplements to provide far-reaching health benefits. We’ll also look into the effects of baicalin with alcohol.

baicalin with Baicalin boosts your health!

1.    Baicalin with GABA


Baicalin with GABA is a potentially great stack for boosting your sleep and promoting healthy REM cycles. Baicalin works on your GABA-A receptors – proving a calming, relaxing feeling without sedation. However, it has other, more complicated methods of maintaining healthy sleep cycles.[1]


One of the best things about GABA is that it doesn’t only help to promote sleep, but it actually improves your sleep cycles.[2] The best thing about a baicalin and GABA supplement is that the GABA would help to provide more sedation, while baicalin would maintain your healthy sleep cycle.


2.    Baicalin with alcohol


Baicalin and alcohol. We knew this was going to come up at some point! Interestingly, baicalin and alcohol target the same GABA subtype receptors! Both alcohol and baicalin target, specifically, GABA-A receptors.[3] [4] While baicalin certainly doesn’t have the same effect as alcohol, their methods of action are similar.

baicalin review Baicalin helps promote healthy sleep cycles

This is important because it means that baicalin could interfere with alcohol. Unfortunately, there haven’t been any studies done to show what these effects would be. It’s quite possible that baicalin may increase the effects of alcohol, but then theoretically it may also decrease the effects, by competing for GABA-A receptors. However, until studies are done there is simply no way to know for sure.


For safety reasons, we recommend avoiding alcohol for a few hours after taking a baicalin supplement.


3.    Baicalin with L-theanine


Baicalin with L-theanine is another potentially great supplement stack. In case you didn’t know, L-theanine is the active compound extracted from green tea. It has calming, relaxing, and focusing effects, and is often used with caffeine for a synergistic stack.[5]


L-theanine indirectly increases the levels of GABA in your body.[6] This means more relaxation. Since baicalin activates the GABA-A receptors, it is theoretically possible that the two supplements would work synergistically to provide a range of benefits. Again, there are no studies yet to back this up.


4.    Baicalin with milk thistle


Now we get to one of our favorite baicalin stacks. It’s pretty well known in the scientific community that baicalin has great effects on protecting your liver from stress. A number of studies have examined this, and scientists are pretty clear on the conclusion.[7] [8]

baicalin with Baicalin with milk thistle is a powerful stack

Milk thistle is a safe and effective dietary supplement for improving overall health. It has been used in a number of remedies but is often taken as an herbal liver support supplement.[9] Milk thistle is especially good for combatting the negative effects of alcohol on your liver.[10]


Taken together, baicalin with milk thistle provide a powerful health stack. This stack is the ultimate protection for your liver. Taken before a night out, or in response to a big hangover, you can be sure that baicalin with milk thistle will be helping your liver.


5.    Baicalin with Inositol

baicalin with Liftmode's inositol: 99%+ purity

Our final health stack is baicalin with inositol. Inositol is a great health supplement for promoting female sexual health, and helping with the symptoms of high blood sugar.[11] Scientists have shown that inositol is really great for improving women's health and fertility [12], and has a number of great health benefits – read our product description here. Taking baicalin with inositol is the ultimate female sexual health supplement. However, inositol doesn’t only benefit women. Its effects on lowering blood glucose and cholesterol are beneficial to everyone!




In conclusion, we’ve already seen the benefits of baicalin supplements in our previous blog posts, and on our product description. This article looked at baicalin with a number of common supplements and substances.


Baicalin is a great health-promoting substance that can be taken synergistically with a number of other dietary supplements.




[1] GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin, F Wang et al., Neuropharmacology. 2008 Dec;55(7):1231-7. doi: 10.1016, available from http://www.ncbi.nlm.nih.gov/pubmed/18723037

[2] Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation, HH Chang et al., J Ethnopharmacol. 2011 May 17;135(2):359-68. doi: 10.1016, available from http://www.ncbi.nlm.nih.gov/pubmed/21419210

[3] The role of GABAA receptors in mediating the effects of alcohol in the central nervous system, M Davies, J Psychiatry Neurosci. 2003 Jul; 28(4): 263–274, available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165791/

[4] Anxiolytic-Like Effect of baicalin and its additivity with other anxiolytics, Z Xu et al., Planta Med. 2006 Feb;72(2):189-92, available from http://www.ncbi.nlm.nih.gov/pubmed/16491459

[5] L-Theanine, Examine.com, available from https://examine.com/supplements/theanine/, retrieved on August 18, 2016

[6] The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent, PJ Nathan et al., J Herb Pharmacother. 2006;6(2):21-30, available from http://www.ncbi.nlm.nih.gov/pubmed/17182482

[7] Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway, Y Xi et al., Cell Physiol Biochem. 2015;35(6):2349-59. doi: 10.1159, available from http://www.ncbi.nlm.nih.gov/pubmed/25896320

[8] Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury, Y Zhao et al., European Journal of Pharmacology, Volume 509, Issues 2–3, 21 February 2005, Pages 195-200, available from http://www.sciencedirect.com/science/article/pii/S001429990401372X

[9] Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.), C Tamayo and S Diamond, Integr Cancer Ther. 2007 Jun;6(2):146-57, available from http://www.ncbi.nlm.nih.gov/pubmed/17548793

[10] Milk thistle in liver diseases: past, present, future, L Abenavoli et al., Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002, available from http://www.ncbi.nlm.nih.gov/pubmed/20564545

[11] Myoinositol metabolism in diabetes mellitus. Effect of insulin treatment, Clements RS Jr, Reynertson R, Diabetes. 1977 Mar;26(3):215-21, available from http://www.ncbi.nlm.nih.gov/pubmed/838172

[12] Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials, V Unfer et al., Gynecol Endocrinol. 2012 Jul;28(7):509-15. doi: 10.3109, available from http://www.ncbi.nlm.nih.gov/pubmed/22296306