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What is DL-Phenylalanine?

DL-Phenylalanine is a combination of the naturally-occurring amino L-Theanine and the laboratory-made D-Phenylalanine. It offers unique benefits when compared to these two substances. People mostly use DL-Phenylalanine to help improve mood and focus. It may also have the potential to reduce sensations of pain.

In this article, we’ll explore DL-Phenylalanine – its major uses, recommended dosage, as well as any side effects and warnings. This is a great place to start learning about DL-Phenylalanine. You could also check out our product description for some more great information about how to use DL-Phenylalanine.

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Benefits and Effects

DL-Phenylalanine has a number of potential benefits. These may include:

1. Pain-relief

Two large studies have indicated the potential use of DL-Phenylalanine in reducing sensations of pain.

In the first study, entitled “DL-phenylalanine markedly potentiates opiate analgesia”, researchers found that DL-Phenylalanine markedly reduced sensations of pain when used together with opiate-based substances. Their hypothesis was that it increases the activity of the ‘endogenous analgesia system’ (EAS) – your body’s natural pain-relief system.[1]

Another study, entitled “Analgesic effectiveness of D-phenylalanine in chronic pain patients”, explored the effects of D-Phenylalanine on compounds in your body called Enkephalins. Enkephalins are part of your natural pain-relief system. Scientists believe that preventing the breakdown of Enkephalins may help with pain relief.[2]

2. May increase focus

liftmode's supplements for pain Liftmode's DL-Phenylalanine, 99% purity

A number of studies have found that DL-Phenylalanine may have the ability to help increase focus and attention. One study, entitled “Treatment of attention deficit disorder with DL-phenylalanine”, tested DL-Phenylalanine’s effects on 19 patients with ADD. Researchers noted a significant increase in mood and attention.[3]

One recent review on the current methods of managing ADD mentioned DL-Phenylalanine. Researchers mention the hypothesis that some symptoms of lack of attention may be due to a deficiency in the catecholamine system. Some amino acid based substances, including DL-Phenylalanine, appear to have the potential to improve focus and attention through their effects on this system.[4]


3. Mood-Lift

Studies have shown that DL-Phenylalanine may have the potential to dramatically and effectively increase mood.

One study was conducted in 1975 on 23 volunteers with depression who had not responded to common medication. The researchers found that there was a significant increase in mood for 17 of the 23 participants, at a dosage of 50 – 100 mg per day.[5]

Another study, from 1977, looked into the effects of DL-Phenylalanine on 20 patients with depression. At the end of the clinical trial, 12 of the 20 patients were discharged from hospital without any further treatment required. Four of the patients experienced mild mood increases while four had no response.[6]


Recommended Dosage

The recommended dosage for DL-Phenylalanine is around 100 – 500 mg per day, based on previous studies.


Side Effects and Warnings

woman running healthy DL-Phenylalanine may help to reduce pain and boost your focus.

No serious adverse effects were found in the above studies and reviews on DL-Phenylalanine. However, mild side effects may include DL-phenylalanine may cause symptoms of anxiety, jitteriness, and hyperactivity in children.

DL-Phenylalanine should not be used by people who are taking antipsychotic medications as it may cause involuntary muscle contractions. DL-Phenylalanine may interact with a number of medications including MAOIs and antipsychotic medication. Please consult your physician if you’re on any medication and would like to try DL-Phenylalanine.[7]



In conclusion, DL-Phenylalanine is a dietary supplement that may have a number of beneficial effects, especially in improving mood and focus. DL-Phenylalanine is a combination of L-Phenylalanine and D-Phenylalanine and may have different effects to either of these substances.

DL-Phenylalanine is used to improve mood, focus and help to ease sensations of pain. It is relatively free from side effects but may interact with a number of medications.



[1] DL-phenylalanine markedly potentiates opiate analgesia - an example of nutrient/pharmaceutical up-regulation of the endogenous analgesia system, AL Russell, MF McCarty, Med Hypotheses. 2000 Oct;55(4):283-8.

[2] Analgesic effectiveness of D-phenylalanine in chronic pain patients, NE Walsh et al., Arch Phys Med Rehabil. 1986 Jul;67(7):436-9.

[3] Treatment of attention deficit disorder with DL-phenylalanine, DR Wood et al., Psychiatry Res. 1985 Sep;16(1):21-6.

[4] An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults, TE Wilens et al., Expert Rev Neurother. 2011 Oct; 11(10): 1443–1465.

[5] Therapy of depression by phenylalanine. Preliminary note, E Fischer et al., Arzneimittelforschung. 1975 Jan;25(1):132.

[6] Dl-phenylalanine in depressed patients: an open study, H Beckmann et al., J Neural Transm. 1977;41(2-3):123-34.

[7] Phenylalanine, University of Maryland Medical Center online, retrieved on December 6, 2016