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Palmitoylethanolamide (PEA) Supplement


Palmitoylethanolamide (PEA) is an endogenous fatty acid produced naturally in cell membranes. PEA supplement is being used for its important neuroprotective, anti-inflammatory, and pain-reducing properties. It has a molar mass of 299.5g/mol and the chemical formula C18H37NO2.


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Palmitoylethanolamide (PEA) Benefits and Uses


Palmitoylethanolamide is an endogenous fatty acid amide, a type of endocannabinoid compound formed in the brain from phospholipids. Chemically, it is the ethanolamide of palmitic (hexadecanoic) acid and is also known as an N-acylethanolamide,


PEA is a signaling molecule that plays an important role in modulating the nervous system. It has anti-inflammatory and analgesic effects and is being studied for its ability to reduce chronic pain. PEA is also shown to inhibit inflammation in the brain, neurotoxicity, and mast cell degranulation, suggesting it has neuroprotective benefits.


Where to Buy Palmitoylethanolamide (PEA) Online?


LiftMode offers a variety of unit sizes of Palmitoylethanolamide, ranging from 50 grams (1.76 Oz) to 1000 grams (35.27 Oz). LiftMode Palmitoylethanolamide is guaranteed 99+% pure.

All our products ship with a certificate of analysis from 3rd-party independent laboratories and all orders are covered by our 90-days refund/reshipment policy to ensure the highest quality.


Shipping restrictions: No shipping restrictions currently apply to this product and we are able to ship internationally. At checkout, the available shipping options for your location will be available.




Palmitoylethanolamide supplements are also known by a few different names, including:


N-palmitoyl ethanolamine


Anandamide (16:0)


Palmitic acid monoethanolamide






Scientific Consensus:


Although there is no standard dosage, studies found a dose range of 300-2400 mg daily of Palmitoylethanolamide to be safe with no associated adverse effects.


There are no recorded drug-drug interactions and very few side effects from Palmitoylethanolamide.


There is not enough data to say whether or not Palmitoylethanolamide is safe for pregnant or breastfeeding women, or if it can be used by children. As with any new supplement, please consult your doctor before trying this product.




All dietary supplements have risks. Please ensure that you are familiar with the latest research on the effects, side effects, benefits, and uses of a supplement before buying it. There are several good informative websites available for further research, such as and RxList.


Store in a cool, dry place. Keep out of reach of children. Do not exceed the recommended serving size. If you have any underlying medical conditions or are taking any medication, please consult a medical professional before using this supplement. 


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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How We Research Our Content


Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.



  • Passavanti, M.B., Alfieri, A., Pace, M.C. et al. (2019). Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review. Systematic Reviews, 8, 9.


  • Lu, H. C., & Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, 79(7), 516–525.


  • National Center for Biotechnology Information (2021).  PubChem Compound Summary for CID 4671, Palmitoylethanolamide. (database entry). Bethesda, MD: US NLM-National Center for Biotechnology Information (NCBI).Retrieved June 17, 2021 from


  • Keppel Hesselink, J. M., & Kopsky, D. J. (2015). Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome. Journal of pain research8, 729–734.