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L-Citrulline DL-Malate 2:1

Buy our L-Citrulline, DL-Malate 2:1 Supplement


L-Citrulline (2-Amino-5-(carbamoylamino)pentanoic acid) is an alpha amino acid first extracted from watermelons. It is used in the urea cycle and is taken to boost L-arginine levels and, thus, nitric oxide levels. DL-Malate (malic acid) is a key compound for the synthesis of ATP. L-Citrulline DL-Malate 2:1 is composed of 2 L-Citrulline molecules bound to a single Malic Acid molecule.


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  1. L-Citrulline DL-Malate 2:1 - 200 Grams (7.05 Oz)

    L-Citrulline DL-Malate 2:1 - 200 Grams (7.05 Oz)


    Availability:In stock

    L-Citrulline DL-Malate 2:1 is a salt made up of two L-Citrulline molecules bound to one Malic acid molecule. L-Citrulline is a naturally occurring α-amino acid which is a key intermediate in mammalian biochemical and metabolic processes, including the urea cycle. Its nomenclature derives from the Latin name of the watermelon fruit (Citrullus vulgaris) - where, interestingly, its concentration exceeds 2mg per gram of fresh watermelon. Malic acid, a dicarboxylic acid found in all living organisms, is a key factor in the biosynthesis of ATP (Adenosine Triphosphate, the universal cellular energy carrier molecule), through its role in the citric acid cycle. The combination salt, L-Citrulline DL-Malate, is the most researched form of L-Citrulline, and the ratio of two to one is generally preferred by athletes because it optimizes the mass of L-Citrulline delivered per serving.

    L-Citrulline is often also considered a kind of camouflaged, enhanced efficacy Arginine supplement, due to its rapid conversion into Arginine by the kidneys after consumption. Unlike most known forms of Arginine, its absorption is not restricted by the Arginine transporter in the intestinal tract, and thus L-Citrulline has significantly reduced (if any) gastrointestinal side effects in comparison to Arginine, even consumed at doses exceeding 15 grams! Arginine, and by extension L-Citrulline, are often supplemented to increase bloodflow through their enhancement of nitric oxide (NO), (which is a small cell signalling molecule that promotes vasodilation and can thus benefit a wide range of human activity). Through this pathway, research indicates that L-Arginine and L-Citrulline may help boost aerobic and anaerobic exercise performance, erection quality, and even healthy growth hormone release.

    L-Citrulline supplementation dose-dependently increases L-Citrulline content in the body; whilst the accompanying Arginine concentration is generally doubled to tripled in a less dose-dependent manner at L-Citrulline serving sizes above 80mg/kg (approximately equivalent to the consumption of 6 grams of L-Citrulline for the average adult). L-Citrulline DL-Malate has been found to increase ATP production in a synergistic manner, and when athletes were given 6 grams prior to exercise, growth hormone levels were increased by over 66% compared to control athletes when measured after a workout.

    This product is 200 grams [7.05 oz] of pure L-Citrulline DL-Malate 2:1, standardized to contain roughly 66% L-Citrulline and 33% Malic Acid at ≥99% purity in a transparent, reclosable plastic jar with an integrated Safety Seal and Shrinkband.

    Also included are the certificate of analysis for the individual L-Citrulline DL-Malate batch and a 1.7cc measuring scoop which measures approximately 1000mg L-Citrulline DL-Malate. One serving is three scoops, or 3000mg.

    More information on L-Citrulline can be found at

    More information on Malic acid can be found at

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L-Citrulline DL-Malate 2:1 Benefits and Uses


L-Citrulline is a naturally-occurring amino acid found in the urea cycle alongside L-arginine and L-ornithine. It has a molar mass of 175.188 g/mol and the molecular formula C6H13N3O3. While L-Citrulline is found in very small concentrations in a variety of food sources, it is primarily synthesized in the body. Research suggests that it helps to improve L-arginine levels in the body and is easily absorbed – making it more effective at improving L-arginine concentrations than traditional L-arginine supplements. It also helps to improve nitric oxide metabolism and helps to regulate ammonia recycling.


L-Citrulline is used today for its ability to improve plasma L-arginine levels after its metabolism in the kidneys. L-arginine is converted into nitric oxide (NO) – a powerful neurotransmitter that helps to relax and dilate blood vessels, improving blood circulation. The primary benefit of L-Citrulline supplementation is to support a healthy circulatory system. However, there are other potential benefits like increased energy levels, reduced fatigue, enhanced mental focus, improved physical performance, reduced muscle soreness, and enhanced libido. L-Citrulline is often touted as a useful pre-workout supplement for bodybuilders and athletes.


Malic Acid is produced naturally in the human body and is taken as a supplement to help boost exercise performance. It has also been researched for its potential benefits for the skin. It is often taken in combination with L-Citrulline as Citrulline Malate. This is also the most researched form. It is believed that the combination of the two helps to improve physical performance further.


Where to Buy L-Citrulline DL-Malate 2:1 Online?


LiftMode offers a variety of L-Citrulline DL-Malatine 2:1 unit sizes of including 200-gram (7,05 Oz) and 500-gram (17,64 Oz) units, at an excellent guaranteed purity of 99+% purity.

All our products ship with a certificate of analysis from 3rd-party independent laboratories and all orders are covered by our 90-days refund/reshipment policy to ensure the highest quality.


Shipping restrictions: No shipping restrictions currently apply to this product and we are able to ship internationally. At checkout, the available shipping options for your location will be available.




L-Citrulline supplements are also known by a few different names, including:


2-Amino-5-(carbamoylamino)pentanoic acid


Watermelon extract



L-Citrulline Malate

Citrulline Malate

2:1 Citrulline Malate salt



Scientific Consensus:


Supplementing with L-Citrulline DL-Malate 2:1 is likely safe for adults when taken at the recommended serving size. L-Citrulline is a naturally-occurring amino acid, and as such, side effects are rare and uncommon.


Special warnings:

L-Citrulline DL-Malate 2:1 may increase blood flow to the heart and may reduce blood pressure. As such, it is very important to talk to your doctor before using this supplement if you are taking any prescription medication – especially any medicine that improves blood flow to the heart (for example, nitrates), drugs for erectile dysfunction, or any antihypertensive drugs.


There is not enough research to support the safety of L-Citrulline supplements for pregnant or breastfeeding women. As such, it is recommended to be avoided.




All dietary supplements have risks. Please ensure that you are familiar with the latest research on effects, side effects, benefits, and uses of a supplement before buying it.


Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions, especially kidney or heart related, are on dialysis or are taking any medication, please consult a medical professional before using this supplement. 


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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How We Research Our Content

Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.

Content Updated On: October 1, 2020




  • Gonzalez, A. M., & Trexler, E. T. (2020). Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature. Journal of strength and conditioning research34(5), 1480–1495.

  • Allerton, T. D., Proctor, D. N., Stephens, J. M., Dugas, T. R., Spielmann, G., & Irving, B. A. (2018). l-Citrulline Supplementation: Impact on Cardiometabolic Health. Nutrients10(7), 921.

  • Gonzales, J. U., Raymond, A., Ashley, J., & Kim, Y. (2017). Does l-citrulline supplementation improve exercise blood flow in older adults?. Experimental physiology102(12), 1661–1671.

  • Papadia, C., Osowska, S., Cynober, L., & Forbes, A. (2018). Citrulline in health and disease. Review on human studies. Clinical nutrition (Edinburgh, Scotland)37(6 Pt A), 1823–1828.

  • Farney, T. M., Bliss, M. V., Hearon, C. M., & Salazar, D. A. (2019). The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants. Journal of strength and conditioning research33(9), 2464–2470.