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  • Stimulates metabolism
  • Helps with weight loss
  • Mildly boosts physical energy


Synephrine HCL or Bitter Orange Extract is a trace amine found in bitter orange (citrus aurantium) and it's extract has a long history of use in Chinese medicine. The primary effect of Synephrine is to slightly increase the metabolism and thereby help with weight-loss. Standard doses of Synephrine HCL are 50-100mg daily or 30-40mins before a workout. Side effects of Synephrine are mild when consumed as recommended, but may include increased heart rate and blood pressure, especially if used in combination with other stimulants.


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Synephrine reviews


“I ordered this product to help with my weight loss. I can assure you that it really works. Not only does it give you a kick of energy without the "jittery" effect...It also makes you not feel like eating as much. I will purchase this product again, just as soon as I run out!” – Shan, Amazon review


“I take 50-100mg of this before a workout or on days I know I'm going to need a bit more than caffeine at work, its a great legal stimulant that leaves you feeling energized and motivated, without the jitters of caffeine. The only negative I can think of is it makes you feel hot, but I guess that's because its thermogenic and raises your metabolism.” – Noah, Amazon review


Synephrine product reviews


  • Synephrine HCL is a trace amine found in Bitter Orange or Citrus aurantium and has a long history of use in Chinese medicine.


  • The primary effect of synephrine is to increase the metabolism and thereby help with weight-loss.


  • Standard doses of synephrine HCL are 50-100mg daily or 30-40mins before a workout.


  • Side effects of synephrine may include increased heart rate and blood pressure when used in combination with other stimulants.


Synephrine background


Synephrine (Synephrine Hydrochloride) is a trace amine found naturally in some plants and animals. The most common source of Synephrine is the Bitter orange fruit (citrus aurantium) which is traditionally used in Chinese medicine. It is very similar both in chemical structural and physiologically to the molecule ephedrine, but is less potent and with less potentially harmful side effects. The primary effect of a Synephrine supplement is to act as a metabolism increasing substance, and can it be used for fat burning and as a stimulant. Synephrine derivatives (compounds based on Synephrine) are sometimes administered intravenously for treatment of bronchial asthma and other respiratory problems. Bitter orange extracts are sometimes applied to the skin as an essential oil extract and for aromatherapy.[1]


Synephrine (Bitter Orange Extract) effects / benefits


Synephrine has the potential for use as a potent substance for the increase of metabolism.[2] A recent study published in the International Journal for Medical Sciences on the metabolic effects of Synephrine both alone and when combined with other flavonoids found that resting metabolic rate was increased by a mean value of 65Kcal for subjects taking a baseline dose of 65mg Synephrine alone.  Importantly, the study found that, even when in combination with the flavonoids Naringin and Hesperidin, Synephrine use did not increase blood pressure or heart rate.

None of the treatment groups exhibited changes in heart rate or blood pressure relative to the control group, nor there were no differences in self-reported ratings of 10 symptoms between the treatment groups and the control group. This unusual finding of a thermogenic combination of ingredients that elevated metabolic rates without corresponding elevations in blood pressure and heart-rates warrants longer term studies to assess its value as a weight control agent.” (G Kaats et al., 2011)[3]

From the Drugs.com website:

The Bitter Orange itself (the parent plant) has been linked to increased systolic and diastolic blood pressure. While a common patented blend of p-Synephrine known as Xenadrine EFX (containing just 5.5 mg Synephrine) has been linked to an increase in blood pressure, another patented blend, Advantra-Z (which contains a significantly higher dose of Synephrine at 46.9 mg along with active bioflavonoids such as Naringen and Hesperidin) has not. Both appear to increase heart rate from baseline though (16.7 BPM and 11.7 BPM, respectively)”

As can be seen, Synephrine used alone does not appear to affect heart rate, when used in addition to other stimulants or flavonoids the effects may include increased heart rate.

It should also be known that Synephrine does not create a false positive result in amphetamine tests, but it is a banned substance in the National Collegiate Athletic Association (NCAA), making Synephrine HCL a controversial chemical in bodybuilding.


Synephrine recommended dosage


Dosage of Synephrine HCL various but normal standard doses are around 50 – 150mg. It is not recommended to exceed the daily dose. It is also important to use Synephrine in cycles.[4]

LiftMode Synephrine is 98% pure and is sold in a 20gram (0.71Oz) reclosable container.


Synephrine side effects and warnings


When taken with other stimulants, large amounts of Synephrine use could possibly heighten the risk of hypertension, heart attack and other serious side effects. Research has found that Synephrine in itself does not raise blood pressure, but there is still a need for more research when it is used with other stimulants like caffeine. [5]

There is an online report of a panic attack induced by use of a Synephrine stacked supplement, containing a host of other stimulants including phenylethylamine and caffeine in high concentrations.

Reports of side effects from Synephrine use alone include triggering headaches and migraines in some people.

It is recommended to consult your physician if you are planning to consume any other stimulants in addition to Synephrine.



[1] “Synephrine” review on examine.com, accessed 12-12-2014

[2] “Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview.” Preuss HG1, DiFerdinando D, Bagchi M, Bagchi, D. J Med. 2002;33(1-4):247-64.

[3] “Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes” Sidney J. Stohs, Harry G Preus Samuel C. Keith, Patti L. Keith, Howard Miller, Gilbert R. Kaats, Int J Med Sci 2011; 8(4):295-301. doi:10.7150/ijms.8.295

[4]  “SYNEPHRINE: Is Chih-shih (Zhishi) Toxic?” by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon

[5] “BITTER ORANGE” review on WebMD, accessed 12-12-2014