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  • Powerful Antioxidant & Anti-Inflammatory
  • Promotes a Healthy Circulatory System
  • Used for Vitality, Relaxation, and Well-Being


An active component of  the Chinese Skullcap (sometimes referred to as Scutellaria baicalensis, Huang qin, or Scutellariae radix), this powerful phytochemical has been used in Traditional Chinese Medicine (TCM) for many centuries as a tonic for promoting vitality and relaxation. Baikal Skullcap extract is best known for its potent antioxidant and anti-inflammatory effects, while also supporting a healthy circulatory system and promote stress-reduction and a relaxed state of mind.


The recommended serving size for this supplement is between 250 – 750 mg, taken once to three times per day. At larger serving sizes, adverse effects are said to be very mild and rare, if present at all. Do not exceed the recommended serving size for this supplement. Please speak to your doctor if you’re using any medication or have any underlying medical conditions. 


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Baicalin Reviews


Baicalin product reviews


  • This supplement is found in the Blue Skullcap plant species and has been used in Traditional Chinese Medicine for a number of health-promoting effects and promotion of relaxation.

  • Benefits include promotion of relaxation, stress-reduction, support for a healthy circulatory system, antioxidant effects, and powerful anti-inflammatory effects, among others.

  • The recommended serving size for this supplement is 250 – 750 mg, taken once to twice per day

  • Even after over 1000 years of use, there are very few side effects associated with extracts from the Baikal Skullcap 




Baicalin (Skullcap, Huang qin, Scutellariae radix, goldenroot, oroxylin A, Scutellaria baicalensis) is a wonderful molecule extracted from a herb that is sometimes referred to as Blue Skullcap or Baicalin Skullcap. It has a history of use in Chinese herbal medicine from over 1000 years ago. Baicalin is a metabolite of the flavonoid baicalein, which is also found in the Skullcap species and the two molecules have synergistic properties.

Baicalin is known to exhibit a multitude of beneficial effects including pain-relief, anti-inflammatory, antioxidant, mood-lifting, and relaxing effects.[1] The Blue Skullcap plant contains a number of active compounds, including:

-        Baicalin (Baicalein-7-glucuronide) and Baicalein, as well as another glycoside known as baicalein-7-O-glucoside.

-        Wogonoside (wogonin-7-glucuronide) and Wogonin, as well as another glycoside known as Wogonin-5-O-glucoside.

-        Oroxylin A (5,7-dihydroxy-6-methoxyflavone) and 7-O-glucoside.

-        Neobaicalein, Scutellarin and Isoscutellarein.

-        Chrysin

-        Viscidulin I and Visdulin III

-        Skullcapflavone I and II




Baicalin Effects / Benefits

The effects of baicalin supplementation are highly beneficial in a wide variety of ways. Its use as an ethanol extract from the Skullcap plant species extends back for over 1000 years in Traditional Chinese Medicine (TCM). It can help to promote a feeling of healthy well-being and help to promote a healthy circulatory system, as two examples of the benefits of this supplement. See below for more benefits.


1.     Powerful Anti-Inflammatory Effects


One of the best-known benefits of this great natural dietary supplement is its ability to act as a powerful anti-inflammatory. A number of studies have indicated that Baicalin acts to reduce inflammation in the body, thereby helping to promote good health.[2] In several animal and cell-line studies, researchers have used Baicalin to effectively reduce inflammation markers.[3]

Reducing inflammation is a great way to promote good health. Unhealthy lifestyle habits can cause an increase in inflammation in the body. Inflammation is, basically, the body’s response to threats. When the human body detects toxins, stress, or infections, it responds with inflammation, which the immune system’s defence taking effect. Having the immune system in constant battle against toxins and stress can be very negative to your health, and has been linked to numerous health issues like gut problems, lack of sleep, low mood, joint problems, and even heart disease. [4]

In terms of how it works, this supplement has been found to inhibit the binding of leukocytes to chemokines and to inhibiting cell migration (a characteristic cause of inflammation). It does not interfere directly with chemokines but rather binds to specific receptors to prevent chemokine-leukocyte binding.[5]


2.     Anti-Stress & Calming Benefits


This great new supplement is also known for its ability to help alleviate feelings of stress and to promote a relaxed state of mind. A very similar compound, Baicalein (also found in the Blue Skullcap) has been shown to bind to GABAA receptors, which is known to promote relaxation.[6] However, Baicalin’s calming effects may not work through this same mechanism.

In fact, the mechanism behind this supplement’s stress-reducing effects is still not yet fully understood. Nevertheless, a number of studies have indicated that it definitely has the potential to help reduce stress.[7] In animal models, for example, both this supplement and its glycoside Baicalein were found to effectively alleviate stress.[8] In other studies, this supplement was compared to other well-known stress-reducing compounds like L-THP, where it was found to have potent relaxation-promoting effects.[9]

In some research, scientists have indicated that Baicalin acts on the GABAA receptors, specifically at the receptor benzodiazepine (BZ) sites. However, some research has shown that this effect may be very mild. Nevertheless, this supplement is known for its ability to produce stress-reduction and mood-life without sedation or muscle relaxation that is characteristic of most GABA agonists. This allows the chemical to promote relaxation devoid of the sedation and muscle-relaxation that is characteristic of most GABA agonists.[10]


3.     Potent Antioxidant Effects


Recent studies into the effects of this great dietary supplement for health, have pointed to its powerful antioxidant effects. In a study published in 2000, on the antioxidant effects of Baicalin, Bacalein, and Wogonin (all extracts from Skullcap species), researchers found that the supplement acts as an effective agent to reduce levels of chytochrome c as well as eliminating superoxide free-radicals, testifying to its powerful antioxidant nature.[11]

Free-radicals are reactive chemical compounds in the body that form during a chemical reaction with oxygen. They form naturally as a part of the body’s metabolism system, but are also generated in response to unhealthy lifestyle choices like smoking and excessive alcohol consumption. Free-radicals react with important cellular components like DNA or the cell membrane, which can cause apoptosis (cell death). As a response, the body uses antioxidants to protect cells against free-radicals.[12]

Natural antioxidants include Vitamin E, Vitamin C, and Beta-Carotene (Vitamin A), all of which are found in high concentrations in plant foods like fruits and vegetables. Research has shown that people who consume no meat or animal-based products and who consume more vegetables and fruits tend to have health benefits, due to the increased intake of minerals, vitamins and antioxidants. [13]

Increasing your intake of antioxidants is definitely a great way to improve vitality and well-being. Interestingly, recent research has indicated that Baicalin has far greater free-radical scavenging (antioxidant) benefits than other natural antioxidants like Vitamin C and BHT. [14]


4.     Supports a Healthy Circulatory System


Recently, interesting research has pointed to Baicalin’s ability to help support a healthy circulatory system. There are a few mechanisms through which this supplement promotes a healthy circulatory system.

Firstly, scientists have found that this supplement can enhance the phosphorylation of AMPK enzyme.[15] This effect may help to regulate levels of hormones found in the blood. AMPK activation is known to help regulate hormone levels as well as to reduce the formation of fat. [16] In this same study, results showed that animals who were administered this supplement over a longer period of time had reduced fat content compared to animals who received placebo. [17]

Secondly,  research suggests that this supplement may help to support a healthy circulatory system through its ability to stimulate the synthesis of nitric oxide (NO).[18] Nitric oxide is responsible for a number of effects on the circulatory system, most significantly vasodilation (increasing the diameter of blood vessels) which allows for better blood circulation.[19] Furthermore, animal studies have indicated that this supplement may help to regulate levels of hormones and to promote a healthy metabolism.[20]


5.     Further Use in Research


Baicalin is being used in a number of studies which are focussing on its potential future benefits for human health. Many of these studies are still very preliminary in their nature. However, it is important that prospective users of Baicalin be made aware of the ongoing research that is being conducted on this highly interesting natural phytochemical.

Significant in vitro research is being conducted on this compound and similar antioxidant derivatives, with a focus on the potential future use for suppressing the growth of malignant cell lines. For example, a recent study – published in the Cancer Letters journal in 2014 – pointed to an interesting potential for further research focussing on reducing the growth of hematological malignancies.[21]

Furthermore, research is being conducted with a focus on the potential to develop this supplement further for its potential effects against bacterial infections and against viral replication. For example, recent in vitro and in vivo studies focussed on dose-dependent inhibitory effects on virulence phenotypes in the Pseudomonas aeruginosa bacteria (by reducing ability to form biofilms).[22] Furthermore, some studies have pointed to a synergistic relationship with oxytetracycline and tetracycline antibiotics against Staphylococcus aureus infections (including methicillin- and tetracycline-resistant strains). [23]


Baicalin Recommended Usage


From Examine.com:

Although there is a lack of human evidence to support the optimal dosage of Sutellaria baicalensis for supplementation purposes, the doses that appear optimal in rat and mouse models suggest that an oral dose of around 500mg of the root extract should be efficacious.”

For a potent, 95-99+% purity extract, the optimal serving size is between 250 – 750 mg, taken once to twice daily. LiftMode Baicalin is sold with a 0.625cc plastic measuring scoop (one level scoop contains 250 mg pure supplement) to help accurately measure the optimum serving.


Baicalin Side effects and Warnings


Even after hundreds of years of use in TCM remedies, this supplement appears to very few noticeable adverse effects, when used in accordance with the recommended serving sizes. WebMD (a well-known medical advise website) advises that there is not enough information currently available to assess this supplement’s potential for adverse effects. However, any adverse effects are likely to be more noticeable at larger serving sizes. [24] 

There is not enough information regarding the safety of this supplement for women who are pregnant or breastfeeding. If you have any underlying medical conditions, please consult with your doctor before using this supplement. Do not take Baicalin supplements if you are using any prescription or OTC medication. Do not exceed the recommended serving size for this supplement.




In summary, this great dietary supplement can be used for a number of important health-promoting benefits. It is a component of the Baikal Skullcap (also known as Huang qin, Scutellariae radix, goldenroot, oroxylin A, Scutellaria baicalensis), that has been used in TCM for hundreds of years.  Today, this compound can be purchased as a dietary supplement to support health and well-being through its numerous biochemical mechanisms.

People who take this supplement tend to use it for its well-established antioxidant and anti-inflammatory effects – both of which are important for supporting a healthy body. Furthermore, research suggests that this supplement can be used to support a healthy circulatory system and to promote feelings of calm and relaxation (stress-reduction). It is also currently being used in a number of studies to pursue potential future health benefits.

The recommended serving size for this supplement is 250 – 750 mg, once to three times daily. Do not exceed the recommended serving size. Information on side effects is limited. Side effects are expected to be rare, and mild if present at all. Do not use this supplement without first talking to your doctor, if you are taking any medication or have any underlying medical conditions.




[1] “Scutellaria baicalensis” Examine.com, available online from https://examine.com/supplements/scutellaria-baicalensis/ [Accessed March 26, 2018]

[2] Lee W, Ku SK, Bae JS. “Anti-inflammatory effects of Baicalin, Baicalein, and Wogonin in vitro and in vivo.” Inflammation. 2015 Feb;38(1):110-25

[3] Guo M, Zhang N, Li D, Liang D, Liu Z, Li F, Fu Y, Cao Y, Deng X, Yang Z. “Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis.” Int Immunopharmacol. 2013 Jun;16(2):125-30.

[4]13 Ways Inflammation Can Affect Your Health”, by Amanda MacMillan, Health.com, available online from http://www.health.com/health/gallery/0,,20898778,00.html [Accessed March 26, 2018]

[5] Li BQ, Fu T, Gong WH, Dunlop N, Kung H, Yan Y, Kang J, Wang JM. “The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines.”. Immunopharmacology. 2000 Sep;49(3):295-306.

[6] de Carvalho RS1, Duarte FS, de Lima TC. “Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice.” Behav Brain Res. 2011 Aug 1;221(1):75-82

[7]New use of baicalin for treating anxiety” WO2004103386A1, WO Application, Patent, available online from https://patents.google.com/patent/WO2004103386A1/en

[8] Liao JF, Hung WY, Chen CF. “Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice.” Eur J Pharmacol. 2003 Mar 19;464(2-3):141-6.

[9] Xu Z, Wang F, Tsang SY, Ho KH, Zheng H, Yuen CT, Chow CY, Xue H. “Anxiolytic-Like Effect of baicalin and its additivity with other anxiolytics.Planta Med. 2006 Feb;72(2):189-92.

[10] Wang F, Xu Z, Ren L, Tsang SY, Xue H., “GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin.” Neuropharmacology. 2008 Dec;55(7):1231-7

[11] Shieh DE, Liu LT, Lin CC. “Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin” Anticancer Research [2000, 20(5A):2861-2865]

[12] Rice University online, “Antioxidants and Free radicals”, available online from http://www.rice.edu/~jenky/sports/antiox.html [Accessed March 26, 2018]

[13] Dinu M, Abbate R, Gensini GF,, Casini A,, Sofi F. “Vegetarian, vegan diets and multiple health outcomes: A systematic review with meta-analysis of observational studies.” Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3640-3649

[14] Peng-fei L, Fu-gen H, Bin-bin Duan, Tian-sheng D, Xiang-lin H, Ming-qin Z. “Purification and antioxidant activities of baicalin isolated from the root of huangqin (Scutellaria baicalensis gcorsi).” Journal of Food Science and Technology. 2013;50(3):615-619.

[15] Ma Y, Yang F, Wang Y, Du Z, Liu D, Guo H, Shen J, Peng H. “CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines.” PLoS One. 2012;7(10):e47900.

[16] Kim J, Yang G, Kim Y, Kim J, Ha J. “AMPK activators: mechanisms of action and physiological activities.” Experimental & Molecular Medicine. 2016;48(4):e224.

[17] Guo HX, Liu DH, Ma Y, Liu JF, Wang Y, Du ZY, Wang X, Shen JK, Peng HL. “Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet.” Acta Pharmacol Sin. 2009 Nov;30(11):1505-12.

[18] Chen Z, Nihei K, Tanaka H, Uda Y, Kabuyama Y. “Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.” Biosci Biotechnol Biochem. 2013;77(3):657-9. Epub 2013 Mar 7.

[19]Nitric Oxide”, Cardiovascular Physiology Concepts, by Richard E. Klabunde, PhD, available online from http://www.cvphysiology.com/Blood%20Flow/BF011

[20] Song KH, Lee SH, Kim BY, Park AY, Kim JY. “Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db Mice.” Phytother Res. 2013 Feb;27(2):244-50.

[21] Chen H, Gao Y, Wu J, et al. “Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies.” Cancer letters. 2014;354(1):5-11.

[22] Luo J, Dong B, Wang K, et al. “Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model.” Seleem MN, ed. PLoS ONE. 2017;12(4):e0176883.

[23] Novy P, Urban J, Leuner O, Vadlejch J, Kokoska L. “In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus.” J Antimicrob Chemother. 2011 Jun;66(6):1298-300