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Choline Bitartrate

  • Improves memory
  • Increases cognitive function
  • Essential nutrient

Choline Bitartrate is a salt form of Choline, an essential nutrient found in many meat, fish and vegetable products and produced endogenously in limited quantities. Choline benefits include increased memory function, anti-inflammatory properties, proper functioning of the body and improved cognitive performance; choline has also been researched for its potential to improve general health and well-being. Nootropic supplementation of Choline Bitartrate has been recommended at 550-3000mg daily.There are no known major side effects of Choline Bitartrate supplementation in recommended amounts, other than the rare possibility of an allergy as found with all supplements.


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Choline Bitartrate reviews


liftmode's choline bitartrate reviews


  • Choline bitartrate is an essential nutrient found in many meat, fish and vegetable products


  • Choline benefits include increased memory function, anti-inflammation, promoting health and well-being, proper functioning of the body and increased cognitive performance


  • Nootropic supplementation of choline bitartrate has been recommended at 550-3000mg daily




Choline is an essential nutrient found in the brain, and can be consumed through many food products like meat, fish, eggs, and some vegetables. Choline is a chemical precursor of the neurotransmitter acetylcholine, which plays a very important role in the functioning of the brain including memory and muscle function. It is this neurotransmitter that gives Choline its major property as a brain-enhancer. Choline is also vitally added to membrane forming compounds including phospholipids and is therefore important in cellular membrane function. Choline is an essential nutrient that must be consumed through food and is often considered a member of the vitamin B group. Choline Bitartrate is a Choline salt that makes Choline easier for the body to absorb.[1]


Choline Bitartrate effects / benefits


Due to the diversity of the roles that Choline plays in the body, Choline deficiency has been linked to numerous adverse effects. Choline supplementation is beneficial in producing a range of effects in the brain.

Support healthy memory and fetal development

Studies on animals have shown that Choline supplementation positively affects brain development in the womb and research suggests that Choline can reverse some of the negative effects of fetal alcohol syndrome. A human hippocampus will continue to develop until the child reaches 4 years of age. Extrapolating to a human model, Choline supplementation during pregnancy and until 4 years of age may be beneficial to increased memory function for life.[2]

Research into supporting a healthy circulatory system

Choline is responsible for many functions including the methylation of homocysteine to methionine. High homocysteine levels in the body have been linked to a multitude of ailments including heart disease, cancer, brain function decline and bone fractures. Supplementation with Choline has been shown to reduce homocysteine levels in the body and thereby has been researched to see if it could lower risk of the above mentioned diseases.[3]


Choline-rich diets are known to reduce inflammation markers in the body, lowering the risk of many inflammation-associated diseases including cancer and brain dementia.

Findings from the ATTICA study indicated that subjects whose diets were rich in Choline and betaine had the lowest levels of several inflammatory markers, including C-reactive protein (CRP), homocysteine, interleukin-6 and tumor necrosis factor” (Zeisel and da Costa, 2009).[4]

Research into women's vitality

Due to the lower levels of oestrogen in post-menopausal women, a low-Choline diet is associated with high risk for a number of diseases including organ dysfunction. Supplementation with Choline is currently being researched to see if it could have the potential to lower the risk of oestrogen-related disorders in postmenopausal women, even in women with a negative genetic predisposition.[5]

As a precursor for Acetylcholine

The main effects of Nootropic Choline Bitartrate are due to it being a precursor to acetylcholine, a very important brain chemical and the first discovered neurotransmitter. Beneficial effects of acetylcholine in the body include proper functioning of the heart (evens heart beat and lowers blood pressure) among others. Acetylcholine works via very complex biochemical processes in almost all areas of the body. Its benefits cannot be stated in a few words, and there is still more research being done on all the roles of this wonderful chemical in the functioning of our bodies. In general, it promotes a healthy, well-functioning body and mind and lowers the risks of many diseases. 

Increases cognitive performance

Low serum Choline levels have long been associated with Alzheimer’s disease (AD), memory loss and lack of cognitive function. Recently, direct evidence has shown that increasing Choline intake improves cognitive function. This study involved over 1300 healthy people who underwent MRI scans as well as neuropsychological examinations after answering questions relating to dietary Choline-intake.[6]


Choline Bitartrate recommended usage


According to many Nootropics websites, the FDA’s recommended daily intake of Choline is 550mg for men and 425mg for women. There are many different forms of Choline supplements available and some are absorbed faster and more efficiently than others. It is said that lipid versions of Choline may have a more efficient absorption than salt-based supplements but this is up to the consumer to decide. For Nootropic effects, a higher dose may be required. Some Nootropic websites estimate the optimum amount of Choline Bitartrate for Nootropic supplementation could range from 550-3000mg Choline daily. As with all supplements, the effects may differ from person to person and it is advisable to start with a smaller dose before increasing and finding the right serving size for you.[7]


Choline Bitartrate side effects and warnings


Choline is very well accepted by the body and is a natural precursor to acetylcholine, one of the most important neurotransmitters involved in functions including memory and proper muscle function. There are minimal reported side effects from Choline Bitartate supplementation at the recommended amounts. If anything, the majority of the population does not consume enough Choline for proper bodily functions.

However, as with any supplement, there is a very rare risk of an allergic reaction. Since Choline is an essential nutrient to the human body, allergic reactions are thought to be extremely unlikely. Should you experience any allergic symptoms, i.e. rash, itchiness, swollen eyes or throat, seek advice from a physician and stop Choline supplementation.  

According to the FDA docket on Choline Bitartrate, excessive amounts can “produce eye, skin and pulmonary irritation, dizziness, nausea, blurred vision, lengthened P-R interval, clinical depression.”[8]




[1] “What is Choline Bitartrate? Benefits, Dosage & Side Effects” nootriment.com, retrieved 19-12-2014


[3] “Choline supplemented as phosphatidylCholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men.” Olthof MR, Brink EJ, Katan MB, Verhoef P, Am J Clin Nutr. 2005 Jul;82(1):111-7.

[4] “Choline: An Essential Nutrient for Public Health” Steven H. Zeisel, M.D., Ph.D. and Kerry-Ann da Costa, Ph.D., Nutr Rev. Nov 2009; 67(11): 615–623.

[5] “Dietary Choline requirements of women: effects of estrogen and genetic variation” KA da Costa et al., Am J Clin Nutr November 2010   vol. 92  no. 5  1113-1119

[6] “The relation of dietary Choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort” Rhoda Au et al., Am J Clin Nutr December 2011   vol. 94  no. 6  1584-1591

[7] “The Beginners Guide to Choline” Purenootropics.net, retrieved 19-12-2014

[8] “FDA Docket: Choline Bitartrate” fda.gov retrieved 19-12-2014