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Dihydromyricetin (DHM)

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Dihydromyricetin – also known as DHM or Ampelopsin – is a relatively new supplement that occurs in a number of plant species and is used for anti-inflammatory, anti-hangover, and liver-support benefits. Ampelopsin has the chemical formula C15H12O8 and a molecular weight of 320.253 g/mol.

 

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Dihydromyricetin (DHM) Benefits and Uses

 

Dihydromyricetin (DHM) is taken by mouth for its purported antioxidant and anti-inflammatory benefits. More recently, research has pointed to its potential use as a supplement to help reduce the symptoms of a hangover and to protect the liver. It has long been used in Traditional Chinese Medicine (TCM) to help reduce the effects of inflammation in the body.

 

Research in animal studies suggests several important mechanisms of action relating to DHM’s ability to protect against hangovers:

-       It triggers the production of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH)

-       DHM appears to improve the efficacy of both ADH and ALDH

-       It helps to reduce fatty acid accumulation in the liver

-       DHM reduced the expression of inflammation markers in the liver, including IL-1β, NF-κB, and TNF-α.

 

Nomenclature:

 

DHM is known by a number of alternative names including:

 

Ampelopsin

(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Ampelopsis

Hovenia dulcis

DHM

Dihydromyricetin

 

 

 

Scientific Consensus:

 

DHM is likely safe when taken by mouth. It is taken commonly to help reduce the symptoms of hangover and protect the liver against inflammation, especially caused by alcohol use. As an oral supplement, the recommended serving size of Dihydromyricetin is 400 mg. Take 1-2 servings up to twice per day.

 

There is still a need for further research into the significance of DHM’s benefits and adverse effects. Nevertheless, Dihydromycetin appears safe for use at the recommended serving size, with only mild side effects very rarely being reported.

 

There is insufficient research to support the use of DHM (Ampelopsin) supplementation during pregnancy and breastfeeding.

 

Disclaimer:

 

All dietary supplements have risks. Please ensure that you are familiar with the latest research on effects, side effects, benefits, and uses of a supplement before buying it.

 

Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions or are taking any medication, please consult a medical professional before using this supplement. 

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

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How We Research Our Content

Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.

Content Updated On: July 6, 2020

 

References:

 

  • Silva, J., Yu, X., Moradian, R., Folk, C., Spatz, M.H., Kim, P., Bhatti, A.A., Davies, D.L. and Liang, J. (2020), Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. Alcohol Clin Exp Res, 44: 1046-1060. doi:10.1111/acer.14326

  • Shen, Y., Lindemeyer, A. K., Gonzalez, C., Shao, X. M., Spigelman, I., Olsen, R. W., & Liang, J. (2012). Dihydromyricetin as a novel anti-alcohol intoxication medication. The Journal of neuroscience: the official journal of the Society for Neuroscience, 32(1), 390–401. https://doi.org/10.1523/JNEUROSCI.4639-11.2012

  • Ren, Z., Yan, P., Zhu, L., Yang, H., Zhao, Y., Kirby, B. P., Waddington, J. L., & Zhen, X. (2018). Dihydromyricetin exerts a rapid antidepressant-like effect in association with the enhancement of BDNF expression and inhibition of neuroinflammation. Psychopharmacology, 235(1), 233–244. https://doi.org/10.1007/s00213-017-4761-z

  • Li, H., Li, Q., Liu, Z., Yang, K., Chen, Z., Cheng, Q., & Wu, L. (2017). The Versatile Effects of Dihydromyricetin in Health. Evidence-based complementary and alternative medicine : eCAM, 2017, 1053617. https://doi.org/10.1155/2017/1053617
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