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Tetrahydroharmine

Buy Our Tetrahydroharmine Supplement

 

Tetrahydroharmine (THH) is a compound found in the plant Banisteriopsis caapi, traditionally used in spiritual journeys by the indigenous shamans of South America as part of the plant infusion Ayahuasca. Modern science has further corroborated the unique nootropic, antioxidant, neuroprotective, neurogenesis-, cognition-, and mood-enhancing properties of THH, which has the molecular formula C13H16N2O and a molecular mass of 216.28 g/mol.

 

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  1. (±)-Tetrahydroharmine (THH) - 5 Grams (0.18 Oz) - ≥98+% Pure

    (±)-Tetrahydroharmine (THH) - 5 Grams (0.18 Oz) - ≥98+% Pure

    $68.68

    Availability:In stock

    Tetrahydroharmine (THH) is one of a family of β-carboline (indole-related) harmala alkaloids, found in the Banisteriopsis caapi (yagé, or ayahuasca) vine and related species, as well as in Peganum harmala (which lends these alkaloids their "harmala alkaloid" nomenclature).

    Infusions from the yagé vine, together with additional synergistic sacred plants such as Psychotria viridis. are likewise known as ayahuasca and are traditionally prepared by a shaman for ayahuasca rituals, continuing a deep cultural history of sacred ayahuasca use by many tribes in the Amazon region.

    Tetrahydroharmine does not exert psychedelic effects in its own right. While not as well studied as more prominent B. caapi alkaloids such as Harmaline and Harmine, Tetrahydroharmine is believed to contribute to the beneficial and mood enhancing effects of ayahuasca.

    Scientific research has revealed that (±)-Tetrahydroharmine functions as a mild serotonin reuptake inhibitor, and one isomer may also have gentle weak reversible MAOI activity (much less potent than that of Harmaline or Harmine), allowing for synergies with other natural phytochemicals that may be deactivated by MAO, including indole derivatives.

    In addition, THH has nootropic potential. Studies suggest that the neuroprotective β-carboline harmala alkaloids from the Banisteriopsis caapi vine, including THH, uniquely promote adult neurogenesis.

    The combination of bioactivities in THH may help support healthy serotonin levels and promote a positive and open mood.

    Research also has uncovered the harmala alkaloids possess unique bioactivity which may support healthy β cell pancreatic function, and growth hormone secretion in humans.

    CAUTION: Tetrahydroharmine is offered as a naturally occurring nootropic compound, and we believe enough evidence is now available that THH may qualify as a valid dietary supplement ingredient, particularly if further research corroborates evidence of its safety when consumed at low to moderate serving size of less than 25mg-50mg. That said, THH should not be consumed by anyone under the age of 18, and should absolutely NEVER be consumed by pregnant or nursing women. It is strongly advised to consult a licensed healthcare professional before consuming THH, to confirm that THH will not cause adverse interactions with medications or preexisting health conditions. The dextrorotatory (+) isomer of Tetrahydroharmine is a the naturally occurring form of the β-Carboline compound found in the Banisteriopsis caapi (yagé, or ayahuasca) vine, and the racemic form, (±)-Tetrahydroharmine, is offered as a raw nootropic compound that has not been adequately researched to be considered safe for consumption as a supplement ingredient in mass market products. (±)-THH is known to possess weak reversible MAOI and mild SSRI properties, and has not been well studied for other pharmacological or toxicological properties. As a result, consumption of (±)-THH (especially in larger amounts than those that can be measured by the enclosed micro transfer scoop, approximately 25mg) may potentially cause adverse interactions with a number of over the counter or prescription medicines, as well as with other serotonergic supplements or tyrosine containing foods. In addition, as with closely related β-Carboline derivatives, Tetrahydroharmine fluoresces brightly under a blacklight, indicating efficient capture and conversion of UV light - and harmala alkaloids are known to potently intercalate with DNA. As a result, it is advised to store THH away from direct sunlight, and to be both aware and cautious of potential DNA damage that could occur with high THH consumption, especially with exposure to UV light. Due to the risk of photosensitivity, it is strongly advised to avoid excessive exposure to UV from sunlight if consuming THH.

    Due to country-specific legal and regulatory restrictions, we do not ship THH to certain countries - including Australia.

    This product is 5 Grams [0.18 oz] of pure Tetrahydroharmine extract in a transparent, reclosable glass jar with an integrated Safety Seal and Shrinkband.

    Also included are the certificate of analysis for the individual Tetrahydroharmine batch and a 0.15cc measuring scoop which measures approximately 50mg of Tetrahydroharmine.

    More information on Tetrahydroharmine can be found at

    https://en.wikipedia.org/wiki/Tetrahydroharmine

    Learn More
  2. (±)-Tetrahydroharmine (THH) - 2 Grams (0.07 Oz) - ≥98+% Pure

    (±)-Tetrahydroharmine (THH) - 2 Grams (0.07 Oz) - ≥98+% Pure

    $37.68

    Availability:In stock

    Tetrahydroharmine (THH) is one of a family of β-carboline (indole-related) harmala alkaloids, found in the Banisteriopsis caapi (yagé, or ayahuasca) vine and related species, as well as in Peganum harmala (which lends these alkaloids their "harmala alkaloid" nomenclature).

    Infusions from the yagé vine, together with additional synergistic sacred plants such as Psychotria viridis. are likewise known as ayahuasca and are traditionally prepared by a shaman for ayahuasca rituals, continuing a deep cultural history of sacred ayahuasca use by many tribes in the Amazon region.

    Tetrahydroharmine does not exert psychedelic effects in its own right. While not as well studied as more prominent B. caapi alkaloids such as Harmaline and Harmine, Tetrahydroharmine is believed to contribute to the beneficial and mood enhancing effects of ayahuasca.

    Scientific research has revealed that (±)-Tetrahydroharmine functions as a mild serotonin reuptake inhibitor, and one isomer may also have gentle weak reversible MAOI activity (much less potent than that of Harmaline or Harmine), allowing for synergies with other natural phytochemicals that may be deactivated by MAO, including indole derivatives.

    In addition, THH has nootropic potential. Studies suggest that the neuroprotective β-carboline harmala alkaloids from the Banisteriopsis caapi vine, including THH, uniquely promote adult neurogenesis.

    The combination of bioactivities in THH may help support healthy serotonin levels and promote a positive and open mood.

    Research also has uncovered the harmala alkaloids possess unique bioactivity which may support healthy β cell pancreatic function, and growth hormone secretion in humans.

    CAUTION: Tetrahydroharmine is offered as a naturally occurring nootropic compound, and we believe enough evidence is now available that THH may qualify as a valid dietary supplement ingredient, particularly if further research corroborates evidence of its safety when consumed at low to moderate serving size of less than 25mg-50mg. That said, THH should not be consumed by anyone under the age of 18, and should absolutely NEVER be consumed by pregnant or nursing women. It is strongly advised to consult a licensed healthcare professional before consuming THH, to confirm that THH will not cause adverse interactions with medications or preexisting health conditions. The dextrorotatory (+) isomer of Tetrahydroharmine is a the naturally occurring form of the β-Carboline compound found in the Banisteriopsis caapi (yagé, or ayahuasca) vine, and the racemic form, (±)-Tetrahydroharmine, is offered as a raw nootropic compound that has not been adequately researched to be considered safe for consumption as a supplement ingredient in mass market products. (±)-THH is known to possess weak reversible MAOI and mild SSRI properties, and has not been well studied for other pharmacological or toxicological properties. As a result, consumption of (±)-THH (especially in larger amounts than those that can be measured by the enclosed micro transfer scoop, approximately 25mg) may potentially cause adverse interactions with a number of over the counter or prescription medicines, as well as with other serotonergic supplements or tyrosine containing foods. In addition, as with closely related β-Carboline derivatives, Tetrahydroharmine fluoresces brightly under a blacklight, indicating efficient capture and conversion of UV light - and harmala alkaloids are known to potently intercalate with DNA. As a result, it is advised to store THH away from direct sunlight, and to be both aware and cautious of potential DNA damage that could occur with high THH consumption, especially with exposure to UV light. Due to the risk of photosensitivity, it is strongly advised to avoid excessive exposure to UV from sunlight if consuming THH.

    Due to country-specific legal and regulatory restrictions, we do not ship THH to certain countries - including Australia.

    This product is 2 Grams [0.07 oz] of pure Tetrahydroharmine extract in a transparent, reclosable glass jar with an integrated Safety Seal and Shrinkband.

    Also included are the certificate of analysis for the individual Tetrahydroharmine batch and a 0.15cc measuring scoop which measures approximately 50mg of Tetrahydroharmine.

    More information on Tetrahydroharmine can be found at

    https://en.wikipedia.org/wiki/Tetrahydroharmine

    Learn More

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Tetrahydroharmine Benefits and Uses

 

Tetrahydroharmine (THH) is a compound found in the plant Banisteriopsis caapi –one of the key ingredients of Ayahuasca. Our Tetrahydroharmine is racemic (±)-Tetrahydroharmine, consisting of both the (+) and (-) optical isomers. It is known that Tetrahydroharmine is a mild serotonin reuptake inhibitor - and additionally it is speculated that one isomer of our (±)-THH, may weakly and reversibly inhibit the activity of an enzyme called monoamine oxidase A (MAO-A), which regulates the functioning of important monoamine neurotransmitters - including dopamine and serotonin. Dopamine and serotonin play important roles in regulating motivation, perception, and overall mood. The net effect of increasing these chemical messengers is said to be an overall improvement in mood, cognitive clarity and increased sense of calm focus.

 

Today, THH can be used as a nootropic and neuroprotective compound that may offer additional beneficial effects including stress relief and mood improvement. A scientific study published in the reknowned journal, Nature, has also recently uncovered a very unique property of THH and related harmala alkaloids in enabling adult neurogenesis! THH is also used synergistically with other MAO substrate ingredients that have cognitive enhancing and mood enhancing effects, including natural indole and phenylethylamine derivatives.

 

Nomenclature:

 

Tetrahydroharmine is known by a number of alternative names including:

(R)-Tetrahydroharmine

 

THH

UNII-AF812R7053

 

(+)-Tetrahydroharmine

 

 

 

Scientific Consensus:

 

Tetrahydroharmine (THH) is a compound that regulates key neurotransmitters namely dopamine and serotonin. It is taken primarily for its nootropic, neuroprotective and neurogenesis promoting effects as well as ability to improvie mood, cognitive function and reduce feelings of stress.

 

Further clinical research is required to fully support the safety, dosage and potential benefits of THH.

 

Disclaimer:

 

All dietary supplements have risks. Please ensure that you are familiar with the latest research on effects, side effects, benefits, and uses of a supplement before buying it.

 

Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions or are taking any medication, please consult a medical professional before using this supplement. 

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

buy our THH supplement 

 

How We Research Our Content

Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.

Content Updated On: July 6, 2020

 

References:

 

  • National Center for Biotechnology Information. PubChem Database(2020). Tetrahydroharmine. Retrieved June, 2020, https://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydroharmine

  • Frecska, E., Bokor, P., & Winkelman, M. (2016). The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization. Frontiers in pharmacology7, 35.

  • Callaway JC, McKenna DJ, Grob CS, et al. Pharmacokinetics of Hoasca alkaloids in healthy humans. J Ethnopharmacol. 1999;65(3):243-256. doi:10.1016/s0378-8741(98)00168-8
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