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Three Ingredients We Keep Coming Back To for Healthy Aging

Three Ingredients We Keep Coming Back To for Healthy Aging

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Talk to your doctor before starting any new supplement, especially if you're pregnant, nursing, or managing a health condition.

Longevity research is rapidly increasing our awareness of supplement options previously unavailable or unfamiliar. It becomes easy for our supplement shelves to fill up with more and more “healthy supplement” options. With so many options becoming available and LiftMode pushing the envelope on cutting-edge supplements, we want to share some very specific options that may be new to most! NMN, Urolithin A, and Huperzine A in my own experience as an employee and customer, and in positive feedback from customers (individual results vary — these are personal experiences, not guarantees), stand out as worth taking a closer look! I’ll try to explain why they deserve a permanent place in our healthy-aging product lineup — and help explain a bit about what each one is actually doing.

NMN: Fueling the Process Behind Cellular Energy

NMN (Nicotinamide Mononucleotide) Powder

NMN (nicotinamide mononucleotide) is a precursor to NAD+, which is a cofactor our cells rely on for a huge range of enzymatic activity. In other words, NAD+ is doing routine and unglamorous cellular housekeeping, but quietly declines as we get older. Supporting NAD+ levels is one of the more studied angles in cellular-health research right now. In particular, how it relates to mental clarity, metabolism, and general cellular resilience. All of which are concerns in healthy aging.

NMN is included in our healthy-aging lineup as it supports the body's natural cellular renewal processes. We aren’t promising anyone an increase in the number of years of life, but we are sharing that healthy supplement routines should be considered along with diet and lifestyle as helpful factors for a more vibrant quality of life, especially in our later years.

Urolithin A: Supporting the Mitochondria That Fuel Everything Else

Urolithin A Powder ≥98% Purity

Urolithin A is a post-biotic compound — our body produces when gut bacteria break down particular compounds, found in foods like pomegranates and berries. Though the amount of Urolithin A our bodies produce, varies a lot from person to person, which is partly why it may be helpful if taken directly as a dietary supplement. Urolithin A has been a focus for research into mitochondrial health and oxidative stress. Mitochondria are our cells' power plants, and Urolithin A is one supplement researchers are looking into further for its role in supporting how well our cells energy production functions over time.

We also recommend Urolithin A to support joint comfort and mobility. As we age, normal movement, and joint function become increasingly important to our day to day mobility and ability to remain fit and active.

Huperzine A: The Sharper, More Targeted Nootropic

Huperzine A 1% Powder Huperzine A 1% Tablets

Huperzine A comes from Chinese club moss and has a long history of use in ancient traditional practice, but what keeps it in our catalog beyond “sales” of course, is its unique mechanism. Huperzine A supports healthy levels of acetylcholine, which is a neurotransmitter tied closely to memory and learning. In our own use as LiftMode employees, and in customer feedback, people reach for it when they want sharper focus and better recall during demanding stretches — studying for Finals, stressful deadline weeks, or to just feel less foggy.

Memory is a common concern at any age, so why not introduce a healthy memory supporting supplement to your routine? In my own personal experience with Huperzine A, as a LiftMode employee and customer — and individual results vary here, this isn't necessarily typical — I found it enhanced my recall! Names and details came to me quicker, rather than having to really focus hard on them. Gradually, people and places that I hadn’t thought of recently became clearer and easier to recall. Customer comments were not typically as strong as my personal experience, but they were similarly positive regarding its benefits.

Why These Three, Specifically

Healthy aging isn't one ingredient's job. We here at LiftMode look for compounds that have clear, explainable mechanisms — what they do in the body and mind — rather than just popular hot-selling products. We also recommend combinations/“Stacks” or “Bundles” of supplements that may help with any given issue. In healthy aging, NMN, Urolithin A, and Huperzine A each target different pieces of the puzzle: cellular energy, mitochondrial support, and sharper cognition. If taken as part of a broader healthy daily routine, like good sleep, daily movement, hydration and diet, supplements may be of benefit to us all.

A Few Safety Notes About NMN, Huperzine A, and Urolithin A

Safety: LiftMode NMN

NMN has been well tolerated in short human trials, but long-term safety data are still limited.

  • Serving size: 100 mg per serving, up to 2 times per day. Start low and do not exceed the label.
  • What the research shows: Human trials have used 250–2,000 mg/day for 2 to 24 weeks. A 2026 meta-analysis of these trials found no increase in adverse events and no rise in liver enzymes (ALT, AST) versus placebo (Yang et al., 2026).
  • Possible side effects: Mild nausea, headache, fatigue and indigestion.
  • Who should avoid it or ask a doctor first: Pregnant or breastfeeding women and anyone under 18, since safety has not been studied in these groups. Also anyone with a medical condition, a history of cancer, or taking prescription medication.
  • Storage: NMN is temperature-sensitive. LiftMode ships it chilled with ice packs and recommends sub-zero (freezer) storage.

Safety: LiftMode Urolithin A Powder (≥98% Purity)

Urolithin A has a good safety record in human trials at 500–1,000 mg/day for up to 4 months, the same range as LiftMode's serving. Urolithin A is newer to the market, and while it's looked well tolerated in the research so far, there isn't much data yet on how it interacts with medications — worth a quick check with your doctor if you're managing a health condition or taking prescription drugs.

  • Serving size: 500 mg per serving; take 1–2 servings once per day, with or without food. Start with one serving to assess tolerance.
  • What the research shows: A standard toxicology review found no toxic or genetic effects in animals (Heilman et al., 2017). Trials in older and middle-aged adults reported side effects similar to placebo (Andreux et al., 2019; Liu et al., 2022; Singh et al., 2022).
  • Possible side effects: Side effects reported in trials were mild and occurred at about the same rate as placebo.
  • Drug interactions: Not yet well studied. Check with a doctor if you take prescription medication.
  • Who should avoid it or ask a doctor first: Pregnant or breastfeeding women, anyone under 18, and anyone with an underlying medical condition (LiftMode's label says not to use it in that case).
  • Storage: Store sealed in a cool, dry place and keep out of reach of children and pets (general guidance; the product page lists no specific storage instructions).

Safety: LiftMode Huperzine A 1% Powder and Tablets

Huperzine A is the most potent of the three and needs the most care: it works like a drug on acetylcholine, and too much causes "cholinergic overload.” Huperzine A is the one ingredient here with a real interaction to flag: because of how it works on acetylcholine, it shouldn't be combined with other acetylcholinesterase inhibitors, anticholinergic drugs, or cholinergic medications without a doctor's guidance. Its effects also last a while in the body, which is why many people cycle it — a few weeks on, then a break — rather than taking it continuously.

  • Serving size: Each tablet or 15 mg scoop of the 1% extract delivers about 150 mcg (0.15 mg) of Huperzine A. Start with one serving. LiftMode's label warns: "Taking multiple servings can result in long-lasting, unpleasant cholinergic overload. Do not exceed the recommended serving size."
  • Why it lasts: Its elimination half-life in healthy adults is about 12 hours (Li et al., 2007). That is why many people cycle it, for example a few weeks on, then a break, instead of taking it every day.
  • Possible side effects: Nausea, vomiting, diarrhea, sweating, dizziness, muscle twitching or cramps, blurred vision, trouble sleeping, and a slowed heart rate.
  • Drug interactions: Do not combine with acetylcholinesterase inhibitors (such as donepezil, rivastigmine or galantamine), anticholinergic drugs, or other cholinergic medications without a doctor's guidance. Tell your doctor or surgeon you take it before any surgery that uses anesthesia.
  • Who should avoid it or ask a doctor first: Anyone under 18, pregnant or breastfeeding, taking prescription or OTC medication, or with a medical condition, per LiftMode's label. Extra caution for people with a slow heart rate or heart rhythm problems, asthma or COPD, epilepsy, stomach ulcers, or urinary or bowel blockage.
  • Storage: Store securely in a dry, cool place away from direct sunlight, out of reach of children and pets.

REFERENCES: NMN

Human trials show NMN reliably raises blood NAD+ and is well tolerated short term. Effects on muscle, metabolism and aging markers are modest and mixed so far.

  1. Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224–1229. PMID: 33888596. A 10-week placebo-controlled trial at 250 mg/day.
  2. Igarashi M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood NAD+ levels and alters muscle function in healthy older men. npj Aging. 2022;8(1):5. PMID: 35927255.
  3. Yi L, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29–43. PMID: 36482258. Compared 300, 600 and 900 mg/day for 60 days.
  4. Fukamizu Y, et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Scientific Reports. 2022;12(1):14442. PMID: 36002548. Tested 1,250 mg/day for 4 weeks.
  5. Irie J, et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine Journal. 2020;67(2):153–160. PMID: 31685720.
  6. Yang W, et al. Safety and metabolism-related outcomes of oral nicotinamide mononucleotide supplementation in adults: a systematic review and meta-analysis. Nutrients. 2026;18(14):2251. PMID: 42514320. Pools 15 trials.
  7. Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism. 2018;27(3):529–547. PMID: 29514064. A readable review of the NAD+ and aging research.

REFERENCES: NMN and Liver Effects at High Doses

The liver concern comes from animal studies at doses far above supplement servings, plus older research on nicotinamide, which NMN breaks down into. Human trials up to 2,000 mg/day have not shown liver enzyme changes.

  1. Cros C, Cannelle H, Laganier L, Grozio A, Canault M. Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats. Food and Chemical Toxicology. 2021;150:112060. PMID: 33587977.
  2. Yu J, Shen Q, Li J. Toxicology study profile of nicotinamide mononucleotide after acute and 90-day sub chronic dosing in Wistar rats and mutagenicity tests. Current Research in Toxicology. 2024;6:100171. PMID: 38765763. Found no adverse effects at up to 800 mg/kg/day for 90 days.
  3. Hwang ES, Song SB. Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment. Biomolecules. 2020;10(5):687. PMID: 32365524. Reviews liver toxicity from very high doses of nicotinamide in humans and rats; the liver is especially exposed because it clears nicotinamide.
  4. Knip M, et al. Safety of high-dose nicotinamide: a review. Diabetologia. 2000;43(11):1337–1345. PMID: 11126400. Reports reversible liver toxicity at very high nicotinamide doses and calls doses above 3 g/day potentially toxic.
  5. EFSA Panel on Nutrition, Novel Foods and Food Allergens. Safety of beta-nicotinamide mononucleotide (β-NMN) pursuant to Regulation (EU) 2015/2283. EFSA Journal. 2026;24(5):e10007. PMID: 42125559. Judged NMN safe for adults at up to 300 mg/day. It notes NMN releases nicotinamide one-for-one, and nicotinamide's EU upper limit is 900 mg/day.
  6. For balance: Yang W, et al. (2026), PMID: 42514320, found no rise in ALT or AST across human NMN trials, and Fukamizu Y, et al. (2022), PMID: 36002548, found none at 1,250 mg/day for 4 weeks.

REFERENCES: Urolithin A

Randomized trials in adults aged 40 and up link Urolithin A to better markers of mitochondrial health and some gains in muscle strength or endurance. Joint findings so far come from cell and animal studies only.

  1. Andreux PA, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2019;1(6):595–603. PMID: 32694802. The first human trial, in older adults.
  2. Liu S, et al. Effect of urolithin A supplementation on muscle endurance and mitochondrial health in older adults: a randomized clinical trial. JAMA Network Open. 2022;5(1):e2144279. PMID: 35050355. Singh A, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine. 2022;3(5):100633. PMID: 35584623.
  3. Heilman J, et al. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food and Chemical Toxicology. 2017;108(Pt A):289–297. PMID: 28757461.
  4. Ryu D, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. 2016;22(8):879–888. PMID: 27400265.
  5. D'Amico D, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell. 2022;21(8):e13662. PMID: 35778837.

Note: most of these studies were funded or co-authored by Amazentis, which makes a branded Urolithin A ingredient.

REFERENCES: Huperzine A

Most Huperzine A research is in people with Alzheimer's disease or dementia, where results are mixed and many trials are small. Evidence in healthy adults is limited to a few small studies.

  1. Yang G, et al. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One. 2013;8(9):e74916. PMID: 24086396. Found benefits on cognition scores but rated trial quality as generally low.
  2. Li J, et al. Huperzine A for Alzheimer's disease. Cochrane Database of Systematic Reviews. 2008;(2):CD005592. PMID: 18425924.
  3. Rafii MS, et al. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011;76(16):1389–1394. PMID: 21502597. A US trial; 200 mcg twice daily did not beat placebo on the main cognition test, while 400 mcg twice daily showed a modest short-term gain.
  4. Sun QQ, et al. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta Pharmacologica Sinica. 1999;20(7):601–603. PMID: 10678121. One of the few studies in healthy people.
  5. Li YX, et al. Pharmacokinetics of huperzine A following oral administration to human volunteers. European Journal of Drug Metabolism and Pharmacokinetics. 2007;32(4):183–187. PMID: 18348466. The source for the roughly 12-hour half-life.
  6. Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacologica Sinica. 2006;27(1):1–26. PMID: 16364207. A broad review of how it works.

As always, none of this replaces a conversation with your doctor, especially if you're pregnant, nursing, taking medication, or managing a health condition.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Talk to your doctor before starting any new supplement, especially if you're pregnant, nursing, or managing a health condition.

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