Honokiol Powder

Regular price $6.68
Regular price $11.68 Sale price $6.68
Unit Size: 1g

Honokiol is a polyphenol isolated from the bark of Magnolia officinalis plant and is traditionally used in Eastern herbal remedies for its calming and neuroprotective properties. It has the chemical formula C18H18O2 and a molecular weight of 266.33 g/mol.


Honokiol Extract Benefits and Uses

Chemically, Honokiol is one of the active components of the Magnolia bark extract. It is a structural isomer of magnolol, a neolignan biphenol and a member of the phenolic class of plants. Honokiol has a high bioavailability and is slightly water-soluble.

Honokiol is pleiotropic – meaning it can affect multiple pathways of the body – and is particularly protective of the brain. Honokiol can preserve the activity of mitochondria and sodium-potassium pumps, two processes that are fundamental for the communication of neurons.

Anecdotally, the antioxidant properties of Honokiol offer numerous health benefits. Honokiol may also promote relaxation and restful sleep.

Honokiol extract supplements are also known by a few different names, including:

  • 35354-74-6
  • Houpu
  • *Magnolia officinalis *
  • Kara-koboku
  • Indian bark
  • 4-O-methylhonokiol
  • Chuan Houpu
  • 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
  • 5,3-Diallyl-2,4-dihydroxybiphenyl

Scientific Consensus

Honokiol is considered a safe and well tolerated herbal supplement with a low toxicity.

There is not enough data to say whether Honokiol extract is safe for pregnant or breastfeeding women, or if it can be used by children. Honokiol has the potential to interact anaesthesia and other medications, and should be avoided before undergoing a surgery.

Instructions & Ingredients

Serving size is 100 mg. As a dietary supplement, take 1 serving up to 2 times per day. lease start with the lowest suggested single serving quantity to assess response.

Supplement Facts
Serving size: 100mg Servings per container: 10
Amount per serving % DV
Honokiol 100 mg
‡ Daily Value not established.

Where To Buy

LiftMode offers a variety of unit sizes of HPLC-tested Honokiol Powder, including a a 10g unit, a 5g unit and a 1g unit. Our Honokiol Powder is of the highest quality.

Disclaimer & Other Info

Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.

The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

Regular price $6.68
Regular price $11.68 Sale price $6.68
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Scientifically Tailored Ingredients

  • Honokiol


Honokiol is a highly active polyphenol compound found in Magnolia officinalis (also known as Magnolia Bark) and is known to hold a wide variety of powerful benefits. Studies indicate that Honokiol can be used as a powerful antioxidant and can promote healthy cognition as well as a healthy sense of relaxation. - Improves Brain Health - Promotes Relaxation - Powerful Antioxidant

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National Center for Biotechnology Information. PubChem Database. Honokiol, CID=72303, (accessed on Dec. 7, 2019).

Chen CM, Liu SH, Lin-Shiau SY. Honokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na+, K+-ATPase activity and mitochondrial functions. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):108-16.PubMed PMID: 17651312.

Woodbury, A., Yu, S. P., Wei, L., & García, P. (2013). Neuro-modulating effects of honokiol: a review. Frontiers in neurology, 4, 130. doi:10.3389/fneur.2013.00130.

Sarrica A, Kirika N, Romeo M, Salmona M, Diomede L. Safety and Toxicology of Magnolol and Honokiol. Planta Med. 2018 Nov;84(16):1151-1164. doi:10.1055/a-0642-1966. Epub 2018 Jun 20. Review. PubMed PMID: 29925102.

Kuribara H, Kishi E, Hattori N, Okada M, Maruyama Y. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol. 2000 Nov;52(11):1425-9. PubMed PMID: 11186252.