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7,8-Dihydroxyflavone Powder

Regular price $19.68
Regular price $19.94 Sale price $19.68
-$0.26
Unit Size: 1g
SKU: 78-DHFL-0001

7,8 – Dihydroxyflavone, also referred to as 7,8 -DHF, is a flavonoid derived from plants with important nootropic effects. It has recently been the subject of much research because of its cognitive and motor enhancing effects on the brain. It has the chemical formula C15H10O4 and a molecular weight of 254.24g/mol.

Description

7,8-DHF (7,8-Dihydroxyflavone) is a naturally occurring flavonoid with possible cognition-enhancing properties. Its recent discovery has spurred research into its unique properties. Due to its low solubility and extensive first-pass metabolism, 7,8-DHF has poor oral bioavailability. However, it is able to cross the blood brain barrier effectively.

7,8-DHF is believed to directly bind the tropomyosin-related kinase B (TrkB) receptor, which is the endogenous receptor for BDNF (Brain Derived Neurotrophic Factor). BDNF can be thought of as “MiracleGro for the brain;” it is one of the main neurotrophic factors responsible for neurogenesis and increases dendritic outgrowth and density. By enhancing TrkB expression, it may be possible to increase the rate new synapses are formed, thus enhancing learning. Some researchers hypothesize that 7,8-DHF does not bind TrkB directly, but instead acts on an unknown pathway that results in the same end result--increased TrkB activity. 7,8-DHF is believed to have a similar degree of neurogenic activities as BDNF.

On top of its effects on neurogenesis, 7,8-DHF is also neuroprotective. It has antioxidant properties in the brain that are independent of its TrkB activity. While these mechanisms are not understood, it is believed to activate the Akt/PKB pathway.

Some animal studies indicate that 7,8-DHF may combat stress and boost mood. It is possible that it is more effective in repairing damaged, rather than healthy neurons and pathways. Anecdotal evidence suggests higher doses may provide an acute mood boost. Sublingual administration is recommended to avoid first-pass metabolism.

This product is 1 grams [0.035 oz] of pure 7,8-Dihydroxflavone, HPLC-verified at ≥98% purity in a transparent, reclosable glass jar with an integrated Safety Seal and Shrinkband.

Also included are the certificate of analysis for the individual 7,8-DHF batch and a 0.15cc measuring scoop. One rounded scoop contains approximately one serving of 40mg 7,8-Dihydroxyflavone.

More information on 7,8-DHF can be found at:

https://en.wikipedia.org/wiki/7,8-Dihydroxyflavone

https://examine.com/supplements/7-8-dihydroxyflavone/

Instructions & Ingredients

As a dietary supplement, take 1 serving up to 2 times per day. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts
Serving size: 40mg Servings per container: 25
Amount per serving % DV
7,8-Dihydroflavone 40mg
‡ Daily Value not established.

Where To Buy

LiftMode offers a variety of unit sizes of 7,8-Dihydroxyflavone Powder, including a a 1g unit, a 2g unit, a 5g unit and a 10g unit. Our 7,8-Dihydroxyflavone Powder is of the highest quality.

Disclaimer & Other Info

Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.

The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

7,8-Dihydroxyflavone powder 1 gram container.
Regular price $19.68
Regular price $19.94 Sale price $19.68
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  • 7,8-Dihydroflavone
7,8-Dihydroflavone
7,8-Dihydroflavone

7,8-Dihydroflavone

7,8-DHF (7,8-Dihydroxyflavone) is a naturally occurring flavonoid with possible cognition-enhancing properties. Its recent discovery has spurred research into its unique properties. By enhancing TrkB expression, 7,8-DHF may help to increase the rate new synapses are formed, thus enhancing learning. Some researchers hypothesize that 7,8-DHF does not bind TrkB directly, but instead acts on an unknown pathway that results in the same end result--increased TrkB activity. 7,8-DHF is believed to have a similar degree of neurogenic activities as BDNF. On top of its effects on neurogenesis, 7,8-DHF is also neuroprotective. It has antioxidant properties in the brain that are independent of its TrkB activity. While these mechanisms are not understood, it is believed to activate the Akt/PKB pathway. * Supports Healthy Memory and Focus * May Promote Adult Neurogenesis * Neuroprotective and Antioxidant

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References

National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 1880, 7,8-Dihydroxyflavone. Retrieved December 12, 2020 from https://pubchem.ncbi.nlm.nih.gov/compound/7_8-Dihydroxyflavone.

García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J. 7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway. Hum Mol Genet. 2017 Aug 15;26(16):3144-3160. doi: 10.1093/hmg/ddx198. PMID: 28541476.

Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H. 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. J Mol Histol. 2014 Apr;45(2):129-40. doi: 10.1007/s10735-013-9539-y. Epub 2013 Sep 13. PMID: 24045895.

Huai R, Han X, Wang B, Li C, Niu Y, Li R, Qu Z. Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone. Am J Hypertens. 2014 May;27(5):750-60. doi: 10.1093/ajh/hpt220. Epub 2013 Dec 6. PMID: 24317273.