CUTTING-EDGE FORMULATIONS

Urolithin A Powder ≥98% pure

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UR-OLTH

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SKU: UR-OLTH

Urolithin A is a naturally occurring metabolite found in many foods, but is most concentrated in natural dietary sources including pomegranates, berries, and walnuts. It is also produced by the gut microbiome from ingested ellagic acid, and is widely studied in aging, gut health, cellular health, and neuroscience .

It has the chemical formula C13H8O4‎ and a molecular weight of 228.20 g/mol.

Urolithin A Benefits and Uses

Urolithin A is a powerful antioxidant studied primarily for its positive properties on aging and longevity, among a vast range of health benefits.

Energy and Endurance

Recent clinical studies have shown that Urolithin A has a strong positive effect on muscle endurance and energy levels when taken on a long-term regimen. It was found to have increased energy levels during exercise and improved muscle health in aging test subjects.

Neuroprotective

Urolithin A is a compound of interest in studies on mitochondrial dysfunction, oxidative stress, and cellular health. It is a widely-studied and powerful antioxidant, working to reduce oxidative damage over time.

Joint Health

Studies on this compound have shown promising results and drawn the attention of those that research joint disorders. A natural postbiotic molecule, researchers have discovered that Urolithin A supports joint health and movement.

Urolithin is known by a number of alternative names, including:

  • Uro-A
  • 3,8-Dihydroxyurolithin
  • Urolithin
  • Mitopure

Scientific Consensus

Warning: There is not enough research about the safety of Urolithin A for pregnant and breastfeeding women. Do not use this supplement if you have any underlying medical conditions.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

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As a dietary supplement, take 1-2 servings once per day with or without food. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 500mg
Servings per container:
Amount per serving: % DV

Urolithin A (≥98% pure)

500mg
‡
LiftMode offers a variety of unit sizes of HPLC-tested Urolithin A Powder ≥98% pure, including a a 10g unit. Our Urolithin A Powder ≥98% pure is of the highest quality.
The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
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Scientifically Tailored Ingredients

Urolithin A is a metabolite compound (postbiotic) resulting from the transformation of ellagitannins by gut bacteria. Supplements containing highly pure Urolithin A have garnered attention in recent clinical studies for their potential to enhance mitochondrial function in human cells, especially as age-related declines in mitochondrial function can impact muscle health and overall energy levels.

Urolithin A was found to improve muscle function in rodents. It also induced mitophagy, improved mobility, and elongated the lifespans of C. elegans. The results of these animal trials and the ability of Urolithin A to improve the antioxidant capacity of cells has led to great interest in the use of Urolithin A supplements in human longevity research.

In addition to supporting healthy aging, Urolithin A supplements may offer a natural boost to muscle function and everyday health and vitality, by supporting mitochondrial function and cellular energy production. Liftmode’s 98% pure Urolithin A is offered in powder form for optimal absorption, and to maximize potential benefits to mitochondria and cellular processes.

**Urolithin A bioavailability and natural sources**

In the diet, urolithin A can be derived via ellagic acid-rich foods such as pomegranate. However, studies have suggested that ellagic acid is not easily absorbed, and the biotransformation of ellagic acid to urolithin A by gut flora might be very low. Additionally, some microbiomes may be completely unable to produce Urolithin A, making direct supplementation the only way for some to benefit from this potent antioxidant and powerful enhancer of mitochondrial health.

Liu, S., D’Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D. J. (2022). Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial. JAMA network open, 5(1), e2144279. [https://doi.org/10.1001/jamanetworkopen.2021.44279]

D’Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022). Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging cell, 21(8), e13662. [https://doi.org/10.1111/acel.13662]

Nishimoto, Y., Fujisawa, K., Ukawa, Y., Kudoh, M., Funahashi, K., Kishimoto, Y., & Fukuda, S. (2023). Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota. Frontiers in nutrition, 9, 1077534. [https://doi.org/10.3389/fnut.2022.1077534]

Cásedas, G., Les, F., Choya-Foces, C., Hugo, M., & López, V. (2020). The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent. Antioxidants (Basel, Switzerland), 9(2), 177. [https://doi.org/10.3390/antiox9020177]

D’Amico, D., & Lotz, M. (2023). Potential of Urolithin A to improve joint health. Aging, 15(6), 1711–1712. [https://doi.org/10.18632/aging.204633]

Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., Auwerx, J., Singh, A., & Rinsch, C. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature metabolism, 1(6), 595–603. [https://doi.org/10.1038/s42255-019-0073-4]

Cho, S. I., Jo, E. R., & Song, H. (2022). Urolithin A attenuates auditory cell senescence by activating mitophagy. Scientific reports, 12(1), 7704. [https://doi.org/10.1038/s41598-022-11894-2]

Toney, A. M., Fox, D., Chaidez, V., Ramer-Tait, A. E., & Chung, S. (2021). Immunomodulatory Role of Urolithin A on Metabolic Diseases. Biomedicines, 9(2), 192. [https://doi.org/10.3390/biomedicines9020192]

National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 5488186, urolithin A. Retrieved October 4, 2023 from [https://pubchem.ncbi.nlm.nih.gov/compound/urolithin-A]