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Yohimbine HCL

  • Promotes a healthy metabolism

  • Increases libido and sexual vitality

  • May help support cognitive function



Yohimbine (Yohimbe, Corynanthe Yohimbe, Yohimbe Bark, Pausinystalia Yohimbe) has long been used as a potent energizing and metabolism-supporting supplement, extracted from the Yohimbe tree in Central Africa. Its powerful effects may include increased sexual performance and libido, healthy weight maintenance, as well as potent energizing effects and increased mental energy/focus.


Recommended use is 1-2 servings of 4mg, once or twice daily. It is not recommended to exceed the recommended allowance. Side effects may include increased blood pressure, nausea, dizziness, rapid heart rate, sleep problems, anxiety, headache and irritability at normal doses and increasing dosage may result in more serious effect. WARNING: Excessively large serving sizes can cause FATAL overdose. Do not exceed the recommended serving size. 


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Yohimbine reviews


This supplement is one of the most discussed, and most controversial, of the natural libido boosters. My search for unbiased reviews yielded mostly fake reviews, biased reviews by people who had a reason to promote it, or warnings against it that also seemed to have an agenda. So I decided to simply try it myself. Overall, it was a decent product deserving a 3 out of 5 rating.” – LiftMode user review


  • This supplement is a potent energizing compound extracted from the Yohimbe tree in Central Africa


  • Effects include increased libido and sexual vitality, support for a healthy metabolism, and increased physical/mental energy


  • Recommended use is around 8-20 mg daily and it is not recommended to exceed the recommended serving size


  • Side effects from large servings may include increased blood pressure, nausea, dizziness, rapid heart rate, sleep problems, anxiety, headache and irritability 




Yohimbine HCl (Yohimbe, Corynanthe Yohimbe, Yohimbe Bark, Pausinystalia Yohimbe) is the active ingredient found in the Yohimbe tree, endemic to Central Africa.

It has potent energizing effects and is effective at boosting libido and sexual vitality, while helping to improve energy levels. This supplement effectively inhibits the re-uptake of norepinephrine, producing noticeable energizing and cognition-enhancing effects. It also reduces the action of the adenyl cyclase enzyme to help promote a healthy metabolism.

The great benefits have been noted most significantly in fasting participants, and it is recommended to use a serving prior to breakfast or before exercising to increase the efficiency of this supplement’s effects. It is not recommended to exceed the recommended serving size and may be unsafe to take when using prescription medication – specifically neurological medication or MAOIs.[1]



Yohimbine Effects / Benefits


1.     Supports a Healthy Metabolism


This supplement has been shown to be an effective supplement for aiding in weight-management programs. It acts as an antagonist (inactivator) of alpha-2-adrenergic receptors, whose function is to stop the activity of adenyl cyclase enzyme and reduce cAMP levels. By allowing continued function of the adneyl cyclase enzyme, and therefore allowing greater levels of cAMP, it is able to prevent the discontinuation of fat-burning, making it an effective supplement for supporting a healthy metabolism. This great supplement is also able to stimulate the release of epinephrine (adrenaline) – see below – which is important for supporting a healthy metabolism.[2]

One human study to back these claims includes a three-week study on twenty healthy male soccer players, where one group was given 40 mg high purity extract daily, while the other was given a placebo. After the three week period, the active group was seen to have significantly greater reduction in body fat percentage than the placebo group (9.3% loss vs 7.1% loss, respectively)[3].

Another study, on the effects of the topical application of this powerful plant extract, found that it was efficient in reducing fat percentage in the thighs of women. After application of the cream, three to four times per week over a four week period, the percentage fat was shown to have significantly decreased.[4]

Neither of the above studies had any reports of side effects from Yohimbine use.

Importantly, studies have found that the metabolism-enhancing effects of this supplement are most effective when taken in a fasting-state – in the morning before breakfast or just before exercise.[5]


2.     May Suppress Appetite


Animal studies have shown that - apart from its metabolism-enhancing properties - this supplement is effective at reducing appetite (especially in overweight animals):

This study noted that 2.1-4.6mg/kg yohimbine was able to reduce food intake to 49-62% of control at the first dose in obese rats, gradually losing efficacy to 56-72% of food intake by day 13...”[6]

Another, similar study, found that this type of supplement had the capacity to decrease food intake in overweight rats.[7] There is still room for more research into whether or not these effects are seen in humans as well as animals.


3.     Helps to Improve Mental Focus


One of the top benefits of this supplement that people are talking about is it’s ability to help improve mental focus and cognitive performance. This is another effect that relates to this supplement’s ability to inactivate alpha-2-adrenergic receptors, allowing for the accumulation of norepinephrine, thereby improving mental focus and energy.

As a stress hormone, norepinephrine affects parts of the brain where attention and responding actions are controlled. Along with epinephrine, norepinephrine also underlies the fight-or-flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. Norepinephrine can also suppress neuroinflammation when released diffusely in the brain from the locus ceruleus” (Norepinephrine, CAAM faculty University notes)[8]

In one recent study, researchers pointed to this supplement’s ability to improve arithmetic task performance while simultaneously improving mental energy. However, some participants experienced anxiety and, while their task performance was still increased, they had more errors than those who didn’t feel anxious.[9] In another study, researchers found that this supplement improved cerebral blood flow and adrenergic activity. [10]

Other studies into the effects of this supplement have shown that it may help to improve attention, especially when taken alongside other compounds used to promote attention.[11]


4.     Increased Libido / Sexual Vitality


This supplement is, primarily, an aphrodisiac supplement and has been shown to be effective in increasing libido and sexual vitality in both animal and human studies. Sexual vitality is closely linked to alpha-2-adrenergic receptor activity and animal studies have indicated that this supplement may be effective in improving libido and vitality, without affecting hormone levels. [12]


In 1998, researchers published a meta-analysis examining all published data on the effects of this powerful compound use for male sexual vitality. The researchers found that this compound improved sexual vitality significantly, at a level far higher than that achieved by use of a placebo.[13] 

In 2002, researchers published a study with similar results, indicating that this compound can be used as a safe dietary supplement to support healthy sexual vitality in men. [14]



Yohimbine Recommended Usage


This supplement is a very potent energizing and aphrodisiac compound and beneficial effects can be felt even at very low serving sizes. Benefits do not necessarily increase with an increase in serving size and it is not recommended to exceed recommended serving instructions.


Most serving sizes are recommended at around 4 - 8 mg, take once or twice per day. LiftMode Yohimbine HCl is 98% pure and is very strong. Some studies have shown that beneficial effects may be felt less after up to two weeks of daily use, so it is beneficial to use this supplement in two-week cycles.[15]


Yohimbine Side Effects / Warnings


This compound is a potent energizing supplement and can cause increased blood pressure, nausea, dizziness, rapid heart rate, anxiety, headache, and irritability, at normal doses.

Very large serving sizes can cause low blood pressure, heart problems and difficulty breathing. There is also a risk of allergic reaction. This supplement may interfere with prescription medication, especially stimulants and MAOIs. It is highly advisable to consult your physician before using supplements if you are taking any medication. This supplement has not been tested for safety in pregnant or breastfeeding women.[16]

Through its effects on the adrenergic system, and especially by increasing norepinephrine levels, this supplement may increase impulsivity. These effects have been noted in one human clinical trial. [17] Despite its energizing effects, this supplement does not appear to affect sleep quality. [18]

Servings greater than 30 mg can cause severe adverse effects. Case studies show that where people consumed excessive amounts of this substance, life-threatening, and, in at least two cases, fatal, overdose has occurred. DO NOT EXCEED THE RECOMMENDED SERVING SIZE. 

For more information on side effects and warnings, please read our blog article on Yohimbine Safety here!




In conclusion, this supplement is a powerful compound extracted from the Central African Yohimbe tree. It can be used for a number of benefits but is most often associated with its aphrodisiac effects and its ability to promote improved libido and sexual vitality. It may also help to support a healthy appetite and metabolism and to improve mental energy and focus.

The recommended serving size for this supplement is 1- 2 servings of 4mg, once to twice daily, and it is not recommended to exceed this serving size. Side effects from larger servings may include headaches, increased blood pressure, and nausea, among others. Side effects are always more noticeable at higher serving sizes.




Medical Disclaimer: 

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.



[1] “Yohimbine” Examine.com, retrieved 28-12-2014


[2] Lafontan M, Berlan M, Galitzky J, Montastruc JL. “Alpha-2 adrenoceptors in lipolysis: alpha 2 antagonists and lipid-mobilizing strategies”. Am J Clin Nutr. 1992 Jan;55(1 Suppl):219S-227S.


[3] Ostojic SM. “Yohimbine: the effects on body composition and exercise performance in soccer players”. Res Sports Med. 2006 Oct-Dec;14(4):289-99


[4] Greenway FL, Bray GA. “Regional fat loss from the thigh in obese women after adrenergic modulation”. Clin Ther. 1987;9(6):663-9.


[5] McCarty MF. “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis”. Med Hypotheses. 2002 Jun;58(6):491-5


[6] “Yohimbine”, Examine.com, available online from https://examine.com/supplements/yohimbine/ [Accessed February 14, 2018]


[7] Callahan MF, Beales M, Oltmans GA.  “Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice.” Pharmacol Biochem Behav. 1984 Apr;20(4):591-9.

[8] “Norepinephrine” CAAM (Computational and Applied Mathematics) department, RICE University notes, Available online, accessed February 14, 2018.


[9] Mizuki Y, Suetsugi M, Ushijima I, Yamada M. “Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety.” Prog Neuropsychopharmacol Biol Psychiatry. 1996 Nov;20(8):1353-67.

[10] Cameron OG, Zubieta JK, Grunhaus L, Minoshima S. “Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans.” Psychosom Med. 2000 Jul-Aug;62(4):549-59.

[11] Arnsten AF. Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction”, CNS Drugs. 2009;23 Suppl 1:33-41


[12] Clark JT, Smith ER, Davidson JM. “Testosterone is not required for the enhancement of sexual motivation by yohimbine”. Physiol Behav. 1985 Oct;35(4):517-21.


[13] Ernst E, Pittler MH. “Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials.” J Urol. 1998 Feb;159(2):433-6.

[14] Guay AT, Spark RF, Jacobson J, Murray FT, Geisser ME. “Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial.” Int J Impot Res. 2002 Feb;14(1):25-31.

[15] “Yohimbine” NYU Langone Medical Centre, retrieved 28-12-2014


[16] “Yohimbine” WebMD, retrieved 28-12-2014

[17] Swann AC, Birnbaum D, Jagar AA, Dougherty DM, Moeller FG. “Acute yohimbine increases laboratory-measured impulsivity in normal subjects.” Biol Psychiatry. 2005 May 15;57(10):1209-11.

[18] Gentili A, Godschalk MF, Gheorghiu D, Nelson K, Julius DA, Mulligan T. “Effect of clonidine and yohimbine on sleep in healthy men: a double-blind, randomized, controlled trial.” Eur J Clin Pharmacol. 1996;50(6):463-5.