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Yohimbine HCL

  • Promotes a healthy metabolism
  • Helps promote healthy libido / sexual performance
  • Boosts cognitive function


Yohimbine has been used as a potent stimulant and fat-burning chemical which was extracted from the yohimbe tree in Central Africa. Its powerful effects may include increased sexual performance and libido, healthy weight maintenance, as well as potent stimulant effects and increased mental energy / focus. Recommended use is around 8-20mg once daily, and it is not recommended to exceed the recommended allowance. Side effects may include increased blood pressure, nausea, dizziness, rapid heart rate, sleep problems, anxiety, headache and irritability at normal doses and increasing dosage may result in more serious effect.


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Yohimbine reviews


Yohimbine product reviews


  • Yohimbine is a potent stimulant and fat-burning chemical extracted from the yohimbe tree in Central Africa


  • Its powerful effects include increased sexual performance and libido, increased fat-burning and weight-loss as well as potent stimulant effects and increased mental energy / focus


  • Recommended use is around 4-8mg daily, and it is not recommended to exceed the recommended allowance




Yohimbine is the active ingredient extracted from the yohimbe tree, found in Central Africa. It has potent stimulant effects and is effective in boosting libido, sexual performance and helping with erectile problems as well as promoting fat-loss. Yohimbine effectively inhibits the re-uptake of norepinephrine, producing its stimulant and mental boosting effects, as well as preventing the action of the adenyl cyclase enzyme to help promote fat-loss. Yohimbine HCL effects are seen most strongly in fasting subjects, and it is recommended to take a dose prior to breakfast or prior to exercising to increase efficiency of effects. It is not recommended to exceed dosage and may be unsafe to take when using prescription medication – specifically neurological medication or MAOIs.[1]


Yohimbine HCL effects / benefits



Yohimbine HCl has been shown to be an effective supplement for aiding in fat-loss programs. It acts as an antagonist (inactivator) of alpha-2-adrenergic receptors, whose function is to stop the activity of adenyl cyclase enzyme and reduce cAMP levels. By allowing continued function of the adneyl cyclase enzyme, and therefore allowing greater levels of cAMP, yohimbine is able to prevent the discontinuation of fat-burning, making it an effective supplement in weight-loss programs. Yohimbine is also able to stimulate the release of epinephrine (adrenaline) – see below – and this is able to stimulate fat-burning in itself.[2]

One human study to back these claims includes a three-week study on twenty healthy male soccer players, where one group was given 40mg yohimbine extract daily, while the other was given a placebo. After the three week period, the yohimbine group was seen to have significantly greater reduction in body fat percentage than the placebo group (9.3% loss vs 7.1% loss, respectively)[3].

Another study, on the effects of the topical application of yohimbine found that it was efficient in reducing fat percentage in the thighs of women. After application of yohimbine cream three to four times per week over a four week period, the percentage fat was shown to have significantly decreased.[4]

Neither of the above studies had any reports of side effects from yohimbine use.

Importantly, studies have found that the fat-burning effects of yohimbine supplementation are most effective when taken in a fasting-state, ie in the morning before breakfast; or just before exercise.[5]


May suppress appetite

Animal studies have shown that - apart from its fat-burning properties - yohimbine HCL is effective at reducing appetite specifically in overweight animals:

This study noted that 2.1-4.6mg/kg yohimbine was able to reduce food intake to 49-62% of control at the first dose in obese rats, gradually losing efficacy to 56-72% of food intake by day 13...”[6]


Increases mental focus

Another effect of yohimbine’s ability to inactivate alpha-2-adrenergic receptors is to allow greater concentrations of norepinephrine and thereby improve mental focus and energy.

As a stress hormone, norepinephrine affects parts of the brain where attention and responding actions are controlled. Along with epinephrine, norepinephrine also underlies the fight-or-flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. Norepinephrine can also suppress neuroinflammation when released diffusely in the brain from the locus ceruleus” (Norepinephrine, CAAM faculty University notes)[7]

Other studies into the effects of yohimbine supplementation for the treatment of ADD have found that it may increase the effectiveness of ADD/ADHD medication, without necessarily being able to treat symptoms on its own.[8]


Increased libido / sexual performance

Yohimbine hydrochloride has been shown to be effective in increasing both libido and sexual performance in animal and human studies. Some sexual desire disorders are linked to improper alpha-2-adrenergic receptor activity, and animal studies have shown yohimbine to be effective in reducing the effects of these disorders in animals. It has also been shown to increase sexual desire in otherwise healthy animals. The mechanism behind this is still being researched but has been found to work without affecting testosterone levels. [9]


Yohimbine HCL recommended dosage


Yohimbine hydrochloride is a very potent stimulant and beneficially effects can be seen even in very low concentrations. Benefits do not necessarily increase with an increase in dosage size and it is not recommended to exceed recommended doses. Most doses are recommended at around 5-10mg daily. LiftMode yohimbine hydrochloride is 98% pure and is very strong. Doses are recommended at 8 - 20 mg once times per day, depending on your weight. Some studies have shown that beneficial effects may lessen after up to two weeks of use, so it may be beneficial to use yohimbine supplements in two-week cycles.[10]


Yohimbine side effects / warnings


Yohimbine is a potent stimulant and can cause increased blood pressure, nausea, dizziness, rapid heart rate, sleep problems, anxiety, headache and irritability at normal doses. Higher doses can cause low blood pressure, heart problems and difficulty breathing. There is also a risk of allergic reaction. Yohimbine may interfere with other prescription medication, especially stimulants and MAOIs and it is highly advisable to consult your physician before using supplements if taking any medication. It has also not been tested on pregnant or breast-feeding women.[11]



[1] “Yohimbine” Examine.com, retrieved 28-12-2014

[2] “Alpha-2 adrenoceptors in lipolysis: alpha 2 antagonists and lipid-mobilizing strategies”, Lafontan M, Berlan M, Galitzky J, Montastruc JL, Am J Clin Nutr. 1992 Jan;55(1 Suppl):219S-227S.

[3] “Yohimbine: the effects on body composition and exercise performance in soccer players”, Ostojic SM, Res Sports Med. 2006 Oct-Dec;14(4):289-99

[4] “Regional fat loss from the thigh in obese women after adrenergic modulation”,Greenway FL, Bray GA, Clin Ther. 1987;9(6):663-9.

[5] “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis” McCarty MF, Med Hypotheses. 2002 Jun;58(6):491-5

[6] “Yohimbine”, Examine.com, retrieved 27-12-2014

[7] “Norepinephrine” CAAM (Computational and Applied Mathematics) department, RICE University notes, retrieved 27-12-2014

[8] “Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction” Arnsten AF, CNS Drugs. 2009;23 Suppl 1:33-41

[9] “Testosterone is not required for the enhancement of sexual motivation by yohimbine” Clark JT, Smith ER, Davidson JM, Physiol Behav. 1985 Oct;35(4):517-21.

[10] “Yohimbine” NYU Langone Medical Centre, retrieved 28-12-2014

[11] “Yohimbine” WebMD, retrieved 28-12-2014