Phosphatidylserine is a phospholipid, or “fatty molecule”, primarily found in the membranes of brain cells. There, they play a fundamental role in cell survival, growth, and cell signaling. As we age, our level of phosphatidylserine can decrease, which contributes to reduced cognitive performance over time.
In our brain cells, phosphatidylserine boosts cognitive function by promoting the production of acetylcholine, an important neurotransmitter for memory and attentiveness. Phosphatidylserine also stimulates the growth and development of new brain cells while protecting the integrity of existing brain cells, overall maintaining brain health.
As a daily supplement, researchers have found that phosphatidylserine is likely effective in enhancing both short and long-term memory, as well as improving cognitive function and learning performance.
Phosphatidylserine Benefits and Uses
Phosphatidylserine is present in a variety of food and animal products, but most phosphatidylserine available is extracted from soy lecithin or cabbage, both of which possess higher than average concentrations of it compared to other plant sources. This phospholipid is made by every cell in the human body, but levels decrease over time throughout the aging process. It has been used anecdotally to improve healthy brain function in aging adults and animals and works by forming a protective layer over crucial cells.
Studies have shown a possible link between phosphatidylserine and cognitive function. Several of these studies, which measured short-term memory, mood, and concentration, concluded that phosphatidylserine improved these measures in control groups.
Phosphatidylserine supplements are also known by a few different names, including:
Ptd-L-Ser
PS
(2S)-2-Amino-3-({[(2R)-2-(butanoyloxy)-3-(propanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoate
Scientific Consensus
Available data indicates that phosphatidylserine supplementation is likely safe at the recommended serving size for up to 3 months at a time. Rare side effects including insomnia and upset stomach can occur at larger servings. Do not exceed the recommended serving size.
Use with caution. Do not use if pregnant or breastfeeding. Do not consume phosphatidylserine if you are taking any cholinergic or anticholinergic drugs. Phosphatidylserine should especially be avoided if you are taking any medications for Alzheimer’s disease or multiple sclerosis.
The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
