How to Take DL-Phenylalanine - The Ultimate Guide!

DL-Phenylalanine is a combination of two forms of Phenylalanine. D-Phenylalanine is a laboratory-made substance that has been studied for pain relief. L-Phenylalanine is a naturally occurring essential amino acid. L-Phenylalanine has a number of great health-promoting benefits and may help reduce feelings of stress. The combination of the two, DL-Phenylalanine, allows you to experience the benefits of both supplements. DL-Phenylalanine usually contains equal amounts of D-Phenylalanine and L-Phenylalanine. In this article, we’ll explore how you can take DL-Phenylalanine for optimum health.

Why take DL-Phenylalanine?

DL-Phenylalanine is a combination of D-Phenylalanine and L-Phenylalanine, two different forms of Phenylalanine. This gives you the benefits of both substances, in combination. D-Phenylalanine is a laboratory-made substance that has been studied for potential pain-relief effects. It has great effects and is especially useful in supporting your natural pain-relief system.[1] L-Phenylalanine is an essential amino acid and is required for your body to function correctly. L-Phenylalanine deficiency is linked to lowered mood and feelings of stress.[2] Higher doses of L-Phenylalanine may have the potential to improve your mood and focus.[3] However, the effect is the exact opposite for a few number of people who suffer from a rare disorder called Phenylketonuria. In this case, supplementing with DL-Phenylalanine is a bad idea as it directly decreases mood and can cause negative health effects.[4]

How to take DL-Phenylalanine?

[caption id=""attachment_1042"" align=""alignright"" width=""300""] Liftmode's DL-Phenylalanine, 99% purity[/caption] You can take DL-Phenylalanine in a number of different ways. The salt form (DL-Phenylalanine HCL) is soluble in water.[5] Some forms are only soluble in warm or hot water. Most people enjoy the slightly sweet taste. However, if you’d rather not taste it, another way to take DL-Phenylalanine is to use a well-measured scoop in a capsule. This means that you can get the benefits of DL-Phenylalanine without the taste. We’d also recommend adding DL-Phenylalanine to a healthy fruit smoothie.  

How much DL-Phenylalanine is too much?

The recommended dosage of DL-Phenylalanine is around 100 – 500 mg per day. Exceeding this dosage may cause negative side effects. Does that are higher than 5000 mg can cause nerve damage.[6]  

Are there DL-Phenylalanine side effects?

[caption id=""attachment_1674"" align=""alignright"" width=""295""] DL-Phenylalanine is know to boost your mood[/caption] The studies that have been done on DL-Phenylalanine so far have indicated that most people are able to tolerate it without experiencing any negative side effects. It’s important to realize that there is still a need for more in-depth research about DL-Phenylalanine and how it works.[7] WebMD simply states that you should consult your pharmacist.[8] In our research, we haven’t seen any indication of negative adverse effects at the recommended dosage. Researchers have not noted any negative dangerous side effects for either L-Phenylalanine nor D-Phenylalanine alone. So, it follows that DL-Phenylalanine is a very safe dietary supplement.[9]  


In conclusion, there are a number of different ways that you can use DL-Phenylalanine to improve your mood and focus. DL-Phenylalanine is best taken at a dosage of 100 – 500mg per day and not ever exceeding 5000 mg per day. It is a little soluble in water and can be taken in a glass of hot water. You can also take DL-Phenylalanine in a healthy smoothie or in capsules. DL-Phenylalanine is a dietary supplement that offers a combination of two forms of the amino acid Phenylalanine.    

Medical Disclaimer

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.


B.Sc. in Molecular Biology and Biochemistry Researched & written by Tristan and verified by the Research Team


  [1] Analgesic effectiveness of D-phenylalanine in chronic pain patients, NE Walsh et al., Arch Phys Med Rehabil. 1986 Jul;67(7):436-9. [2] Effects on mood of acute phenylalanine/tyrosine depletion in healthy women, M Leyton et al., Neuropsychopharmacology. 2000 Jan;22(1):52-63. [3] L-Phenylalanine, PubChem, Open Chemistry Database, retrieved on 8 December, 2016 [4] High phenylalanine levels directly affect mood and sustained attention in adults with phenylketonuria: a randomised, double-blind, placebo-controlled, crossover trial, AE ten Hoedt et al., J Inherit Metab Dis. 2011 Feb;34(1):165-71.   [5] Phenylalanine, PubChem, Open Chemistry Database, retrieved on December 8, 2016 [6] Phenylalanine, WebMD Vitamins and Supplements, retrieved on December 8, 2016 [7] DL-phenylalanine versus imipramine: a double-blind controlled study, H Beckmann et al., Arch Psychiatr Nervenkr (1970). 1979 Jul 4;227(1):49-58. [8] DL-Phenylalanine,, retrieved on December 8, 2016 [9] Phenylalanine, University of Maryland Medical Center online, retrieved on December 8, 2016

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