How To Take Yohimbine HCl - LiftMode

So, how to take Yohimbine HCl? Well, this article will answer your questions! We’ve compiled the top five questions about how to take Yohimbine and answered them using the scientific research that is available today. In this blog post, we discuss the recommended dosage, when to take Yohimbine, how long Yohimbine lasts, what to take it with, and any potential safety issues. Yohimbine HCl is an active compound that used to be extracted from the bark of the Yohimbe tree in Central Africa. Modern science allows us to synthesize the compound – eliminating the need to destroy trees in Africa.

1.    What’s the Yohimbine Recommended Dosage

The recommended serving size for Yohimbine HCl is around 4 – 8 mg, taken once to two times daily. The serving size depends on your weight and the desired strength of effects. Yohimbine HCl is a very strong aphrodisiac supplement with powerful effects. You really don’t need much to feel the benefits, which increase the longer that you take it. In fact, we recommend starting with a serving of only 2 mg to assess how your body responds. It may be beneficial to use Yohimbine for around two to three weeks before experiencing positive results. [1] IMPORTANT: It is possible to overdose on Yohimbine. Overdose can cause loss of consciousness, seizures, coma, and death. DO NOT EXCEED THE RECOMMENDED SERVING SIZE.  DO NOT TAKE YOHIMBINE IF YOU ARE USING ANY MEDICATION.  

2.    When to Take Yohimbine?

Yohimbine HCl may increase your catecholamines – epinephrine and norepinephrine. These promote wakefulness and alertness.[2] This is why we recommend that the best time to take Yohimbine is at least a few hours before you plan on going to sleep. The best times to take Yohimbine would be in the morning and early afternoon.  

3.    How Long Does Yohimbine Last?

Yohimbine HCl has a very short half-life of only around 1 – 1.5 hours. This means that after around 3 hours its effects should have worn off entirely. The length of the effects depends on your metabolism and what you have in your stomach.[3] It is recommended to take Yohimbine on an empty stomach to allow for better absorption and so that the effects last longer.  

4.    Is Yohimbine HCl Safe?

Yohimbine HCl is considered safe when consumed by itself and at the recommended serving size.[4] However, Yohimbine is very powerful and may interact with a number of medications and other herbal supplements. Do not use Yohimbine with other medication unless prescribed by your doctor.   Yohimbine may also have negative effects when used at higher-than-normal servings. Do not exceed the recommended serving size for Yohimbine HCl. Some potential side effects include itching, high blood pressure, restlessness, and headaches. Side effects are rare at the recommended serving size.[5] IMPORTANT: See our blog post on Yohimbine Safety here!

5.    What to Take Yohimbine with?

Yohimbine is a potent aphrodisiac and vitality booster! The best way to benefit from its effects is to take Yohimbine HCl on its own, on an empty stomach. Yohimbine may interact with a number of medicines and we definitely do not recommend taking it if you are using medication. At least one study has pointed to a synergistic relationship between Yohimbine HCl and L-Arginine, a common amino acid.[6]  


[caption id=""attachment_1727"" align=""alignright"" width=""300""] Yohimbine may help boost your libido![/caption] In conclusion, if you were wondering how to take Yohimbine HCl then we’ve done our best to answer the top five questions. The best questions about how to take Yohimbine include: when to take it, what to it take with, how long it lasts, is it safe, and how to take Yohimbine.   The Yohimbine HCl recommended dosage is 4 – 8 mg once or twice daily. Do not exceed the recommended serving size. Start by using a lower serving size to assess how you react. Yohimbine is best taken on an empty stomach and its effects last for around 3 hours in total. Yohimbine is safe and relatively free from side effects when used at the recommended dosage.    

Medical Disclaimer

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.


B.Sc. in Molecular Biology and Biochemistry Researched & written by Tristan and verified by the Research Team


  [1]Yohimbine”,, retrieved on December 14, 2016 [2] MM Murburgh et al., “Effects of yohimbine on human sympathetic nervous system function”, J Clin Endocrinol Metab. 1991 Oct;73(4):861-5. [3] SK Guthrie et al., “Yohimbine bioavailability in humans”, Eur J Clin Pharmacol. 1990;39(4):409-11. [4] SW Tam et al., “Yohimbine: a clinical review”, Pharmacol Ther. 2001 Sep;91(3):215-43. [5] JG Susset et al., “Effect of yohimbine hydrochloride on erectile impotence: a double-blind study”, J Urol. 1989 Jun;141(6):1360-3. [6] S Akhondzadeh et al., “Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial”, Iran J Psychiatry. 2010 Winter; 5(1): 1–3, PMC3430403

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