Top 3 Levo-Tetrahydropalmatine (L-THP) Benefits

Levo-Tetrahydropalmatine (-THP) is the active compound found in the Corydalis Yanhusuo herb, endemic to China. There are numerous L-THP benefits that people are talking about today. In China, L-THP is marketed and sold as an anti-stress and pain-relieving compound and is sometimes called Yan Hu Suo. Benefits of L-THP (tetrahydropalmatine) include promotion of healthy sleep as well as calming and relaxing effects. Additionally, L-THP may be able to help reduce sensations of pain, without acting as a euphoric agent. L-THP also has powerful benefits on the circulatory system and acts as an anti-inflammatory compound to promote good health.

1.    L-THP Benefits: Calming and Anti-Stress

L-THP is used primarily for its ability to help reduce feelings of stress, to improve mood status, and sometimes for its ability to reduce sensations of pain. In China, L-THP is used for reducing symptoms of pain and as a muscle-relaxant and is sold under the name Rotundine. [1] L-THP has inhibitory effects on dopamine D1 and D2 receptors in the brain.[2] It also has mild inhibitory effects on the serotonin and adrenergic receptors and may have a positive effect on GABA-A transmission.[3] What this means is that L-THP is a suitable supplement for improving mood, and helping to promote healthy sleep, without the potential for developing a habit or dependency. L-THP does not cause the euphoria that is often associated with anti-stress compounds, giving it far less potential for abuse. In fact, some research has even pointed to L-THP’s potential for future use in the development of compounds to assist with people battling addiction. [4]  

2.    Helps Promote Good Health

[caption id=""attachment_2806"" align=""alignright"" width=""300""] Along with anti-inflammatory supplements, a healthy diet and lifestyle promote well-being and longevity![/caption] L-THP is also a powerful anti-inflammatory compound, meaning that it may help to promote good health. Keeping your body free from inflammation is one of the most important features of a healthy lifestyle. Although there is no ‘magic-bullet’ to destroy inflammation, using anti-inflammatory supplements in conjunction with a healthy diet and lifestyle may help to promote better health, longevity, and well-being. [5] Furthermore, some studies have suggested that L-THP may help to promote a healthy mental state. Several clinical trials have examined the potential for L-THP’s development as an antipsychotic agent and to help restore a normal balance of chemicals in the brain.[6]  

3.    Supports a Healthy Circulatory System

One of L-THP’s most important benefits is its ability to help support a healthy circulatory system. The molecule interacts with receptors in your body in a number of ways to promote healthy blood-flow and to help regulate blood pressure. [caption id=""attachment_2805"" align=""alignright"" width=""278""] L-THP may help to promote a healthy circulatory system.[/caption] Firstly, L-THP acts as a potent calcium-channel blocker, preventing calcium from entering cells of the heart and blood vessel linings, thereby helping to promote and regulate healthy blood pressure. [7] PubChem, the open chemistry database, lists L-THP as a calcium channel blocker as well as an anti-arrhythmic agent. [8] Calcium channel blockers are used to reduce blood pressure, relieve chest pain, and to promote a regular heartbeat/to prevent arrhythmia. [9] All of these benefits are important in maintaining a healthy circulatory system.   Secondly, animal studies have indicated that L-THP works as a powerful cardio-protective supplement, helping to prevent damage to the heart under a variety of stresses. [10] In animal models, supplementation with L-THP significantly reduced myocardial infarction size and improved cardiac function after 8 weeks of administration. [11] There is still room for research into whether these benefits are applicable to human hearts, but this preliminary data looks promising.  


[caption id=""attachment_2804"" align=""alignright"" width=""300""] L-Tetrahydropalmatine from LiftMode is >98% pure. CLICK the photo to find out more![/caption] In summary, the top benefits of Levo-Tetrahydropalmatine can be divided into three groups – namely, its effects on the mental state, its anti-inflammatory effects, and its ability to help promote a healthy circulatory system. L-THP is also said to help regulate the pain response and may be used to help support a calm and healthy mental state/headspace. LiftMode L-THP is considered safe at the recommended serving size of 30-60 mg, no more than twice per day. This product is sold with a measuring scoop and in a re-sealable container.    

Medical Disclaimer

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.


B.Sc. in Molecular Biology and Biochemistry Researched & written by Tristan and verified by the Research Team


[1] Rotundine: ab143130,, available online from [Accessed 15 February 2018] [2] Hu JY, Jin GZ. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. Zhongguo Yao Li Xue Bao. 1999 Aug;20(8):715-9. [3] Figueroa-Guzman Y, Mueller C, Vranjkovic O, et al. Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats. Drug and alcohol dependence. 2011;116(1-3):72-79. [4] Jia Bei W, John R. M. L-Tetrahydropalmatine: A Potential New Medication for the Treatment of Cocaine Addiction. Future medicinal chemistry. 2012;4(2):10.4155/fmc.11.166. [5] Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity. Clinical Trial at the University of Maryland, Stanley Medical Research Institute. 2017. Available online from [6] Wang SM, Han C, Lee SJ, Jun TY, Patkar AA, Masand PS, Pae CU. Investigational dopamine antagonists for the treatment of schizophrenia. Expert Opin Investig Drugs. 2017 Jun;26(6):687-698 [7] Huang K, et al. Blocking L-calcium current by l-tetrahydropalmatine in single ventricular myocyte of guinea pigs. Zhongguo Yao Li Xue Bao. 1999 Oct;20(10):907-11. [8] Tetrahydropalmatine. CID 72301. PubChem, Open Chemistry Database, US National Library of Medicine, available online from [9] Calcium channel blockers. MayoClinic (2017). Available online from [10] Han Y, et al. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischemia-reperfusion injury in rats. PLoS One. 2012;7(6):e38627 [11] Wu L, Ling H, Li L, Jiang L, He M. Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction. J Pharm Pharmacol. 2007 May;59(5):695-701.

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