What is Yohimbine HCl?

So, what is Yohimbine HCl? Well, it’s the active compound found in the Yohimbe tree in Central Africa. This compound has been used for hundreds of years as an aphrodisiac and to improve men’s sexual health and vitality. Western science is only just catching onto the benefits of this interesting supplement. So, if you’re wondering “what is Yohimbine?”, it’s a great dietary supplement and aphrodisiac with a number of potential benefits. These include the potential ability to help maintain a healthy weight, to promote sexual vitality, and possibly to improve cognitive performance. We’ve outlined these benefits for you below:

What is Yohimbine HCl? Benefits and Effects


1. Potential to help maintain a healthy weight

One of the top advantages of Yohimbine HCl is it’s potential to help maintain a healthy weight. In one study, twenty soccer players were given Yohimbine and another twenty were given a placebo. The Yohimbine group had a significantly lower fat mass at the end of the three-week trial. It didn’t affect muscle mass or athletic performance and none of the participants noted any side effects.[1] In another study, twenty obese women underwent a three-week clinical trial to test the effects of Yohimbine on weight. They all ate a low-energy diet (1000 kcal/day) for the period of the trial. Half the women were given a placebo and the other half were given Yohimbine HCl four times per day. The Yohimbine group had a significantly better weight reduction at the end of the trial. Yohimbine also seemed to promote a healthy sympathetic system. Again, none of the women reported any side effects during the trial.[2]  

2. May help promote men’s libido and sexual performance

[caption id=""attachment_809"" align=""alignright"" width=""300""] Liftmode's Yohimbine HCL: 98%+ purity[/caption] A review from 2001 looked into all the research on Yohimbine up to that time. The researchers found that there had still been relatively few well-designed studies to test Yohimbine’s effects. However, of the studies that they looked at the outcomes showed that Yohimbine had a moderate effect on men’s libido. Specifically, it helped promote healthy sexual vitality in men. In all the studies, Yohimbine was relatively free from side effects at normal dosages.[3] Another study examined using Yohimbine HCl with L-Arginine, a common amino acid, to help promote men’s sexual vitality. Forty married men between 25 and 50 with varying degrees of low sexual vitality were given either placebo or Yohimbine HCl over a 4 week period. The researchers found a significant difference between the groups after 4 weeks, in terms of sexual health.[4]  

3. Potential to improve cognitive performance

There is still a need for more studies into the effects of Yohimbine on cognitive performance. However, a number of studies have indicated that it may have the potential to help improve cognition. For example, a clinical review entitled “Cognitive enhancers for the treatment of anxiety disorders” listed Yohimbine as a potential botanical agent to promote cognition and reduce stress.[5] Furthermore, a study looked into the effects of startling and fear on human emotions and fear-related memory. The researchers found that Yohimbine HCl stimulated people’s bodies to produce epinephrine and norepinephrine. They also found that Yohimbine improved the recovery time from symptoms of fear.[6]  

Yohimbine HCl Recommended Dosage

[caption id=""attachment_1720"" align=""alignright"" width=""300""] Yohimbine HCl may help to maintain a healthy weight[/caption] From previous studies, the recommended amount of Yohimbine HCl is around 4 - 8 mg per serving. This can be taken once to two times per day. Yohimbine has a very short half-life and is eliminated in under 1 hour. Yohimbine has a varying rate of absorption which appears to have something to do with what’s in your stomach when you take it. It is more effective to take Yohimbine HCl on an empty stomach.[7]  

Side Effects and Warnings for Yohimbine

In most studies, no adverse effects were reported. However, in one study there were four side effects reported by both the Yohimbine group and the placebo group, which included itching, high blood pressure, headache, and difficulty sleeping.4 There has been at least one case of neurotoxic effects after a very high dose of Yohimbine. A bodybuilder took around 5 grams of Yohimbine HCl before a competition. He suffered a loss of consciousness and seizures. He recovered after 12 hours in a hospital. Please note that this was a very high dose of Yohimbine given that the recommended dosage is 4 - 8 mg.[8] NOTE: At least two cases of fatal overdose have been reported for Yohimbine. DO NOT EXCEED THE RECOMMENDED SERVING SIZE.  DO NOT USE YOHIMBINE IF YOU ARE TAKING ANY MEDICATION.  For more information read our blog post on Yohimbine Safety.

So, what is Yohimbine HCl - Conclusion

In conclusion, Yohimbine HCl is a great dietary supplement for a number of benefits. It is used mostly as an aphrodisiac and in promoting men’s vitality and men’s sexual health. It also has the potential to help maintain a healthy weight and possibly to improve cognition. Yohimbine HCl is a very strong extract from the Yohimbe plant in Central Africa. The recommended serving size is around 4 - 8 mg, once to twice daily. We recommend starting with a smaller serving of 2 mg to assess how your body responds. At the recommended serving size, most users do not experience any side effects. However, serious negative effects can occur at large servings and we urge you to not exceed the recommended serving size.    

Medical Disclaimer

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.


B.Sc. in Molecular Biology and Biochemistry Researched & written by Tristan and verified by the Liftmode.com Research Team


[1] Ostojic SM, “Yohimbine: the effects on body composition and exercise performance in soccer players”, Res Sports Med. 2006 Oct-Dec;14(4):289-99. [2] Kucio C et al., “Does yohimbine act as a slimming drug?”, Isr J Med Sci. 1991 Oct;27(10):550-6. [3] SW Tam et al., “Yohimbine: a clinical review”, Pharmacol Ther. 2001 Sep;91(3):215-43. [4] S Akhondzadeh et al., “Efficacy and Safety of Oral Combination of Yohimbine and L-arginine (SX) for the Treatment of Erectile Dysfunction: a multicenter, randomized, double blind, placebo-controlled clinical trial”, Iran J Psychiatry. 2010 Winter; 5(1): 1–3, PMC3430403 [5] SG Hoffmann et al., “Cognitive enhancers for the treatment of anxiety disorders”, Restor Neurol Neurosci. 2014;32(1):183-95 [6] M Soeter, M Kindt, “Noradrenergic enhancement of associative fear memory in humans”, Neurobiol Learn Mem. 2011 Sep;96(2):263-71. [7] SK Guthrie et al., “Yohimbine bioavailability in humans”, Eur J Clin Pharmacol. 1990;39(4):409-11. [8] A Giampreti et al., “Acute neurotoxicity after yohimbine ingestion by a body builder”, Clin Toxicol (Phila). 2009 Sep;47(8):827-9

Leave a comment

Please note, comments need to be approved before they are published.