1. Regulation of Oxidative Stress and Immunity
Glutathione plays an essential role in our antioxidant defence system and plays a vital role in regulating oxidative stress in our bodies. So, what exactly is oxidative stress and why is it so important? Oxidative stress is essentially the result of having too many unstable molecules called free radicals and too few antioxidants in your body. [3] Under normal conditions, our cells produce free radicals which are mopped up by antioxidants. Over time, oxidative stress can cause damage to proteins and DNA ultimately increasing the risk of developing neurodegenerative diseases and chronic diseases of lifestyle. [4] It is therefore important to ensure that your body has adequate levels of antioxidants to prevent oxidative stress. Clinical trials have studied glutathione for its role in reducing oxidative stress markers. In a 2016 study, an oral dose of 300mg of glutathione taken daily for three months was associated with reduced oxidative stress markers. [5] In addition to this study, a 6-month clinical trial using a dose of 250mg or 1000mg oral glutathione daily reported reduced oxidative stress markers in both glutathione dosage groups. Furthermore, the study also reported an increase of up 30% in immunity cells in study participants taking 1000mg daily, suggesting a role of glutathione in supporting normal immune function. [6]2. Health Ageing Benefits & Healthy Skin
Research has shown oral glutathione to have promising benefits in improving skin quality. In a 2017 study, female participants between the ages of 20 - 50 years were given an oral Glutathione supplement (250 mg) to take before bed each night for three months. The study found a significant improvement in wrinkles and an overall improvement in skin elasticity in the group receiving glutathione when compared to the placebo group. [7] These findings are further supported by a more recent 2019 review that looked at the clinical effect of glutathione on skin conditions. Three randomized control trials using oral glutathione between 250 to 500 mg/day were included in the review. In the review, it was found that overall daily glutathione supplementation improves skin wrinkles, skin elasticity, and UV spots [8]3. Helps Support a Healthy Liver
Researchers have studied glutathione’s role in liver health, including in alcoholic and non-alcoholic fatty liver — a condition in which excessive fat builds up in the liver. [9] [10] In 2017, one of the first studies looking at the effects of Glutathione supplements on non-alcoholic fatty liver was published. The study included a total of 29 patients each given an oral dose of 300mg glutathione daily for four months. At the end of the study, the researchers reported an improvement in liver function markers in participants who received glutathione.[11] The authors did, however, conclude that more large-scale clinical trials are needed to verify its efficacy.Conclusion - Top 3 S-Acetyl L-Glutathione Benefits
In summary, research has studied glutathione for its role in helping to regulate oxidative stress, supporting normal immune function, and supporting healthy liver function. Studies have also explored glutathione’s role in supporting skin quality and healthy ageing in older women. Our naturally-produced Glutathione stores naturally deplete as we get older and therefore taking a daily glutathione supplement is something we should all consider as we get older! An important factor to consider is that all clinical studies referenced in this article have used oral supplementation methods and there is insufficient evidence to support the safety of glutathione via other administration methods. When taken orally, usual glutathione supplements are unstable and not well absorbed. However, in an acetylated form, S-Acetyl L-Glutathione is much better absorbed. It is always important to read labels carefully before purchasing any supplement. Make sure you purchase S-Acetyl L-Glutathione to improve the supplement's absorption profile!Medical Disclaimer
Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand the potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.
Michaela
BSc(Med)(Hons) Nutrition & Dietetics Researched & written by Michaela and verified by the Liftmode.com Research Team
