Top 3 S-Acetyl L-Glutathione Benefits (2019) - LiftMode

Glutathione is an essential antioxidant that is used by every cell in our bodies. Research has shown that higher glutathione levels are associated with fewer illnesses and overall better self-rated health. [1] As we get older, our ability to produce Glutathione decreases.[2] S-Acetyl L-Glutathione provides a far better absorption profile than average Glutathione supplements. Poor nutrition, stress, and environmental toxins can also leave our bodies with inadequate glutathione levels.  In this article we explore the top 3 S-Acetyl L-Glutathione benefits and what it is most effective for. We answer why supplementing with this antioxidant, especially as we get older, may provide us with many health benefits.

1. Regulation of Oxidative Stress and Immunity

Glutathione plays an essential role in our antioxidant defence system and plays a vital role in regulating oxidative stress in our bodies. So, what exactly is oxidative stress and why is it so important? Oxidative stress is essentially the result of having too many unstable molecules called free radicals and too few antioxidants in your body. [3] Under normal conditions, our cells produce free radicals which are mopped up by antioxidants. Over time, oxidative stress can cause damage to proteins and DNA ultimately increasing the risk of developing neurodegenerative diseases and chronic diseases of lifestyle. [4] It is therefore important to ensure that your body has adequate levels of antioxidants to prevent oxidative stress. Clinical trials have shown Glutathione to be effective in reducing oxidative stress markers. In a 2016 study, an oral dose of 300mg of glutathione taken daily for three months was shown to reduce oxidative stress markers. [5] In addition to this study, a 6-month clinical trial using a dose of 250mg or 1000mg oral glutathione daily, found glutathione to be effective in reducing oxidative stress markers in both glutathione dosage groups. Furthermore, the study also reported an increase of up 30% in immunity cells in study participants taking 1000mg daily, suggesting an important role of glutathione in supporting and upregulating our immune systems. [6]

2. Health Ageing Benefits & Healthy Skin

Research has shown oral glutathione to have promising benefits in improving skin quality. In a 2017 study, female participants between the ages of 20 - 50 years were given an oral Glutathione supplement (250 mg) to take before bed each night for three months. The study found a significant improvement in wrinkles and an overall improvement in skin elasticity in the group receiving glutathione when compared to the placebo group. [7] These findings are further supported by a more recent 2019 review that looked at the clinical effect of glutathione on skin conditions. Three randomized control trials using oral glutathione between 250 to 500 mg/day were included in the review. In the review, it was found that overall daily glutathione supplementation improves skin wrinkles, skin elasticity, and UV spots [8]

3. Helps Support a Healthy Liver

Research suggests that glutathione is an effective strategy in improving liver damages in both alcoholic and non-alcoholic fatty liver, [9] a condition in which excessive fat builds up in the liver, leading to reduced liver function and poor health. [10] In 2017, one of the first studies looking at the effects of Glutathione supplements on nonalcoholic fatty liver disease was published. The study included a total of 29 patients each given an oral dose of 300mg glutathione daily for four months. At the end of the study, a significant improvement in liver function was found in all patients who received glutathione treatment.[11] The authors did, however, conclude that more large-scale clinical trials are needed to verify its efficacy.

Conclusion - Top 3 S-Acetyl L-Glutathione Benefits

In summary, research supports the use of glutathione in reducing oxidative stress in our bodies, boosting our immune systems as well as having the potential to improve liver function in cases of fatty liver. Clinical data also supports the use of glutathione in improving skin quality and supporting healthy ageing in older women. Our naturally-produced Glutathione stores naturally deplete as we get older and therefore taking a daily glutathione supplement is something we should all consider as we get older! An important factor to consider is that all clinical studies referenced in this article have used oral supplementation methods and there is insufficient evidence to support the safety of glutathione via other administration methods. When taken orally, usual glutathione supplements are unstable and not well absorbed. However, in an acetylated form, S-Acetyl L-Glutathione is much better absorbed. It is always important to read labels carefully before purchasing any supplement. Make sure you purchase S-Acetyl L-Glutathione to improve the supplement's absorption profile!  

Medical Disclaimer

Not intended to treat, diagnose, or cure any disease or ailment. Please read and fully understand the potential adverse effects before using this product. These statements have not been reviewed by the FDA and are not written by a medical professional. Please consult your doctor before using any supplements, especially if you have any medical conditions.


BSc(Med)(Hons) Nutrition & Dietetics Researched & written by Michaela and verified by the Research Team


[1] Julius, M, Lang, CA, Gleiberman, L, Harburg, E, DiFranceisco, W, and Schork, A. Glutathione and morbidity in a community-based sample of elderly. J Clin Epidemiol. 1994; 47: 1021–1026 [2] Sekhar, R. V., Patel, S. G., Guthikonda, A. P., Reid, M., Balasubramanyam, A., Taffet, G. E., & Jahoor, F. (2011). Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. The American journal of clinical nutrition94(3), 847–853. doi:10.3945/ajcn.110.003483 [3] Betteridge, D. (2000) What is oxidative stress? Metabolism.49: 3-8. [4] Lushchak, V. I. (2012). Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions. Journal of Amino Acids, 2012, 1–26.doi:10.1155/2012/736837 [5] Irie, M., Sohda, T., Anan, A., Fukunaga, A., Takata, K., Tanaka, T., … Sakisaka, S. (2016). Reduced Glutathione suppresses Oxidative Stress in Nonalcoholic Fatty Liver Disease. Euroasian journal of hepato-gastroenterology6(1), 13–18. [6] Richie, J. P., Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J. S., Schell, T. D., & Muscat, J. E. (2014). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition, 54(2), 251–263. [7] Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, cosmetic and investigational dermatology10, 147–153. [8] Dilokthornsakul, W., Dhippayom, T., & Dilokthornsakul, P. (2019). The clinical effect of glutathione on skin color and other related skin conditions: A systematic review. Journal of Cosmetic Dermatology. [9] Sacco, R., Eggenhoffner, R., Giacomelli, L. (2016) Glutathione in the treatment of liver diseases: insights from clinical practice. , 62(4):316-324. [10] Sethi, S. (2019) “Everything You Need to Know About Fatty Liver”. Healthline [Online] Available at [11] Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., … Nakajima, A. (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC gastroenterology17(1), 96.