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Oleamide

  • Calming
  • Promotes healthy sleep
  • Promotes appetite

Oleamide is a naturally occurring chemical that is produced in humans from oleic acid and ammonia and is known to accumulate in the brain prior to sleep and in states of sleep deprivation. Effects and benefits of oleamide include the ability to support healthy stress levels, promotion of healthy sleeping patterns as well as an increase in appetite.
Dosage is normally anywhere between 50-200mg daily, depending on the desired effects. Side effects have not really been studied properly but oleamide is known to produce locomotive depression so it is not advised to drive or operate machinery when under the influence of oleamide.

 

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Oleamide reviews

 

“Oleamide is interesting, in high doses its relaxing and gave a relaxed feeling... it also made me a little dizzy but not in a bad way. In lower doses it gives you mild relaxation, helping somewhat with (stress) and tension. Since its from olive oil I would assume it would also possess properties beneficial to overall heath but I'm not sure as I could not find much information about Oleamide on its own. 
I would recommend it for sleep, relaxation, and muscle tension and of course with Liftmode you get the best quality for the best price and the best service!!” – LiftMode user review

 

 “This product is very interesting, as it is a lipid that also can have effects on certain receptors in the body. There is not much information available for oleamide, or stearamide, but I tried 100mg and I experienced more than placebo. There was an uplift in mood, and I certainly have an increased appetite every time I try it. Don't expect anything like the jwh line of chemicals - it isn't that obvious, but, in my opinion, it is more that placebo. Also, some of the research available on oleamide might make you think it will put you to sleep, but that hasn't been the case for me.” – Amazon review

 

Oleamide product reviews

 

  • Oleamide is known to accumulate in the brain prior to sleep and in states of sleep deprivation

 

  • Effects and benefits of oleamide include supporting healthy stress levels, promotion of healthy sleeping patterns as well as an increase in appetite

 

  • Dosage is normally anywhere between 50-200mg daily, depending on the desired effects

 

  • It is not advised to drive or operate machinery when under the influence of oleamide

 

Background

 

Oleamide is a relatively new Nootropic that occurs naturally in animals and is produced in humans from Oleic Acid (from Olive oil) and ammonia. It has been seen to accumulate in the central nervous system (CNS) before sleep, producing calming and tranquilizing effects. It is naturally metabolized by an endogenous enzyme known as FAAH.

Oleamide is associated with an increase in GABA signals (known to produce calming and sedating effects) as well as an increase in appetite. At higher doses it may produce depression in locomotion (associated with effects on GABA neurotransmissions) and bring on restful sleep. Sleep latency (the time from wakefulness to sleep) is reduced at all doses. Oleamide is sometimes sold in powder form, and is also included in some cosmetics as oleamide DEA.[1]

 

Oleamide benefits / effects

 

Calming

While the calming effects of oleamide are still being researched, preliminary studies on animals have shown strong support of healthy stress levels and mood increases, which look promising.

Firstly, research has shown that oleamide is able to increase GABA signalling (specifically GABAA subtypes) without actually interfering with the GABA receptors.[2] This is important because GABA is known to be the primary inhibitory neurotransmitter in the central nervous system and is associated with calming, anti-stress and pain relief effects. GABAA is specifically targeted in many tranquilizers and sedatives and an increase in GABAA activity is directly linked to calming effects.[3]

Secondly, studies on rats have shown that oleamide is able to exert mood-lifing effects on animals in doses that are too low to create locomotive effects (5mg/kg bodyweight). The support of healthy stress levels and social calming effects of intravenous oleamide were seen to last for 30-60 minutes.

Thirdly, animals studies have shown the potential effects of large doses of oleamide (10mg/kg bodyweight) in treatment of depression. Animal studies showed greater results in tests designed to test for depression in mice and rats treated with intravenous oleamide. The mechanisms behind these effects are still being examined.[4]

 


Promotion of healthy sleep and memory

Recent research into the effects of oleamide in animals showed that intravenous doses resulted in a dose-dependent decrease in sleep latency (time to fall asleep), reduction in locomotion and a decrease in body temperature. With the onset of sleep, the research showed a depression in locomotion. This was shown to be reversible by using serotonin supplements, so that sleep would be induced without any apparent effects on locomotion ability.[5]

Human trials are still required, but searching online databases for reports, reviews and experiences seems to testify to the strength of this chemical to induce restful sleep.

Oleamide is known to enhance the signals of GABA (see above) through an unknown mechanism. Enhanced GABA function is associated with calming and promotion of sleep. Many Nootropic chemicals that produce calming or sleep-aid effects target GABA receptors. This may also be a cause of the locomotive disruptions seen in animal tests. Alcohol is an example of a GABAA agonist (increases GABA transmissions) - as well as many sedatives and tranquilizers – and is definitely associated with impaired locomotive function at higher doses.

Oleamide has been shown to be able to reduce the effects of long-term potentiation (LTP) which may be a causal agent in the development of diseases like Alzheimer’s, depression and even epilepsy.[6]

 


Increased appetite

Oleamide is known to increase appetite in animal studies and reports and reviews by users online appear to back these findings. In a recent animal study, food intake was shown to have increased significantly 3hrs after oleamide supplementation.[7]

Furthermore, oleamide has been observed to interact with endogenous cannaboid receptors – specifically CB1 at high concentrations. This may give oleamide possible psychoactive effects at high doses, and may also be an explanation for the increased appetite observed a few hours after dosing. Lastly, oleamide has shown anti-neuroinflammatory effects which may protect the brain and may also be associated with its proposed ability to bind to multiple neurotransmitter systems, including cannaboid receptors.[8]

 

Oleamide recommended dosage

 

Human studies on the effects of oleamide are still required and therefore doses are obtainable only through the experimentation of others. MSDS of oleamide provides no extra information. Online reviews appear to recommend oleamide doses of around 50-200mg, depending on the desired effect. Of course, these doses are dependent on a number of factors including personal sensitivity (weight, metabolism, etc).

At low doses, oleamide is usually seen to produce effect that support a healthy mood; medium doses produce the same with added appetite increase as well as a possibility of a few psychoactive effects; and higher doses appear to induce the onset of sleep.

LiftMode allows you to buy 99% pure oleamide with a certificate of analysis.

 

Oleamide side effects / warnings

 

The effects and side effects of oleamide have not been fully researched as yet and human studies are still required. Doses at those recommended do not appear to have any side effects on reviews online, but it is always a good idea to do a background check before deciding to purchase a supplement, especially if it is very new on the market. Allergic reactions may occur and some people may have a hypersensitivity to the effects. However, it can also be said that since oleamide accumulates naturally in the brain before sleep, side effects should be few (the body has a very efficient method of metabolising excess oleamide – the FAAH enzyme destroys over-produced oleamide).

Oleamide is associated with a decline in locomotive function even at medium doses so users should not attempt to drive or to operate heavy machinery when under the influence.

 

References

[1] “Oleamide” examine.com, retrieved 23-12-2014

[2] “Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide” Dale L. Boger, Jean E. Patterson, and Qing Jin Proc Natl Acad Sci U S A. Apr 14, 1998; 95(8): 4102–4107

[3] “Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems” Fedorova I, Hashimoto A, Fecik RA, Hedrick MP, Hanus LO, Boger DL, Rice KC, Basile AS, J Pharmacol Exp Ther. 2001 Oct;299(1):332-42

[4] “Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems” Fedorova I, Hashimoto A, Fecik RA, Hedrick MP, Hanus LO, Boger DL, Rice KC, Basile AS, J Pharmacol Exp Ther. 2001 Oct;299(1):332-42

[5]

[6] “Plasticity in the human central nervous system” S. F. Cooke, T. V. P. Bliss, Brain: A Journal of Neurology, DOI: http://dx.doi.org/10.1093/brain/awl082 1659-1673 First published online: 3 May 2006

[7] “Oleamide and anandamide effects on food intake and sexual behavior of rats” Martínez-González D, Bonilla-Jaime H, Morales-Otal A, Henriksen SJ, Velázquez-Moctezuma J, Prospéro-García O, Neurosci Lett. 2004 Jun 24;364(1):1-6

[8] “Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems” Fedorova I, Hashimoto A, Fecik RA, Hedrick MP, Hanus LO, Boger DL, Rice KC, Basile AS, J Pharmacol Exp Ther. 2001 Oct;299(1):332-42

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