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Buy our 7,8- Dihydroxyflavone Supplement


7,8 - Dihydroxyflavone, also referred to as 7,8 -DHF, is a flavonoid derived from plants with important nootropic effects. It has recently been the subject of much research because of its cognitive and motor enhancing effects on the brain. It has the chemical formula C15H10O4 and a molecular weight of 254.24g/mol.


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7,8- Dihydroxyflavone Benefits and Uses


7,8-DHF is believed to have important health benefits on the brain. It is thought to activate the ‘tropomyosin-related kinase B (TrkB)’, the usual target receptor of ‘Brain Derived Neurotropic Factor’ (BDNF). BDNF is a peptide and essential contributor to brain function because it promotes neuronal and synaptic growth. Therefore, having adequate amounts of the BDNF peptide is crucial to prevent neurodegeneration.


However, because BDNF does not effectively cross the blood-brain barrier, it has poor absorption in the brain. Anecdotally, 7,8 – DHF may mimic the effects of BDNF. It is thought to be a TrkB agonist as it binds to the Trkb receptor in a similar way as BDNF. Studies have shown it may have similar neuroprotective effects on the brain as BDNF because of its ability to cross the blood-brain barrier. These include improved memory, reduced stress, and repair of damaged neurons.


Furthermore, 7, 8-DHF may also exert antioxidant activity on the body by replenishing glutathione, as well as decrease inflammation and blood pressure. That being said, these findings stem from animal studies and have not yet been proven on human models.


Where to Buy 7, 8- Dihydroxyflavone Online?


LiftMode offers a variety of unit sizes of 7, 8-DHF including 2-gram (0.07 Oz) and 10-gram (0.35 Oz) units. LiftMode 7, 8-DHF is guaranteed 98+% pure.

All our products ship with a certificate of analysis from 3rd-party independent laboratories, and all orders are covered by our 90-days refund/reshipment policy to ensure the highest quality.


Shipping restrictions: No shipping restrictions currently apply to this product and we are able to ship internationally. At checkout, the available shipping options for your location will be available.




7, 8-DHF supplements are also known by a few different names, including:



7, 8 - Dihydroxyflavone



7, 8-Dihydroxyflavone hydrate

7,8- Dihydroxy-flavone

7, 8 - DHF




Scientific Consensus:


Currently, there are no human studies on 7,8 - DHF. The only human doses are estimated based on rat studies. Oral administration of 5 mg/kg to 30 mg/kg of bodyweight per day of 7, 8-DHF is the most commonly used dosage in studies.


7,8 - DHF supplements may cause mild and rare side effects such as dizziness, insomnia and nausea. Due to lack of insufficient data regarding the safety of this product for pregnant or breastfeeding women, it should be avoided.




All dietary supplements have risks. Please ensure that you are familiar with the latest research on the effects, side effects, benefits, and uses of a supplement before buying it.


Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions or are taking any medication such as antidepressants, anticoagulants, and sleep medications, please consult a medical professional before using this supplement. 


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


How We Research Our Content


Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.

Content Updated On: December 31, 2020


buy 7,8-dihydroxyflavone online





  • García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J. 7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway. Hum Mol Genet. 2017 Aug 15;26(16):3144-3160. doi: 10.1093/hmg/ddx198. PMID: 28541476.


  • Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H. 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. J Mol Histol. 2014 Apr;45(2):129-40. doi: 10.1007/s10735-013-9539-y. Epub 2013 Sep 13. PMID: 24045895.


  • Huai R, Han X, Wang B, Li C, Niu Y, Li R, Qu Z. Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone. Am J Hypertens. 2014 May;27(5):750-60. doi: 10.1093/ajh/hpt220. Epub 2013 Dec 6. PMID: 24317273.