+1(855) 228-9993 (M-F, 9-6)       Email: liftmode@liftmode.com 

Phenylethylamine

  • Rapid, powerful increased energy for up to 1-2 hours
  • Strong Mood-lift which can last several hours
  • Increased focus and endurance

 

Phenylethylamine (PEA, β-phenylethylamine (β-PEA), 2-phenylethan-1-amine) is a trace amine found in a number of plant and animal species and derived from the amino acid L-Phenylalanine. When taken as a dietary supplement, Beta-Phenylethylamine HCl improves the output of neurotransmitters called catecholamines, while reducing their re-uptake – resulting in increased concentrations in the brain and plasma. Catecholamines include epinephrine (adrenaline), norepinephrine, and dopamine.  

 

The effects of a Phenylethylamine supplement include a powerful increase in mental and physical energy, significant mood enhancement, improved cognitive performance, and a decrease in appetite, as well as several other secondary effects. Phenylethylamine is rapidly broken down and has a half-life of only around 1-2 hours. It is often taken in combination with Hordenine to lengthen the duration of the experience. The recommended Phenylethylamine dosage is around 100-500 mg, in the morning or 30-40 minutes prior to exercise.

 

1 Item(s)

Set Descending Direction
per page

1 Item(s)

Set Descending Direction
per page

Phenylethylamine HCL reviews

 

After doing some research on using this with Hordenine, I was anxious to see how I might respond. It was not so much for any quick euphoria, but to have more energy AND a good mood, too. Too many supplements may offer alertness or awakeness, but how many help you feel wide awake, but jittery, irritable, or impatient. I was pleasantly surprised about how my mood was elevated and I also felt a lot of energy and a somewhat curbed appetite. While the main affect may be for a few hours, I felt energized for several hours beyond what I expected and it was a natural return to baseline, not a crash. I was also impressed with LiftMode's customer service.”

– Jim, LiftMode Phenylethylamine review

 

I ordered PEA with Hordenine after much research. My goal was to get some extra energy in the morning as it it sometimes difficult to wake up/get up. The combo seems to work but I have been very careful to follow the dosages outlined by Liftmode. The danger is high BP and HR. I have not experienced this but be careful with this substance as it can act as a powerful stimulant of the body and mind if combined with an MAOB inhibitor.”

– Brian, LiftMode phenylethylamine review.

 

  • Phenylethylamine is a trace monoamine found in all animals and plants that acts as a modulator of catecholamines

 

  • The benefits of phenylethylamine supplements include mood-lift and increased energy, general feelings of well-being, increased learning capacity and is responsible for the ‘runner’s high’

 

  • Serving size of phenylethylamine is recommended at around 100 - 500 mg in the morning or 30 - 40 mins before exercise

 

  • Side effects are dose-dependent and may include headaches and upset stomach. If used in combination with other stimulants, side effects may be more pronounced.

 

Background

 

Phenylethylamine (also known as PEA, β-phenylethylamine (β-PEA) and 2-phenylethan-1-amine) is a naturally occurring trace monoamine and a derivative of the amino acid phenylalanine. Phenylethylamine is found naturally in all mammals in low levels and acts in a variety of important functions – most prominently as a modulator of catecholamine emissions (dopamine, norepinephrine and epinephrine) in the brain. It helps trigger the brain to release dopamine and norepinephrine and thereby acts as a powerful energizer and mood-enhancer as well as an appetite suppressor.[1]

Online personal Phenylethylamine reviews on various forums have reported some interesting mood enhancements including a feeling of general well-being, creativity, awareness, attention and increased sexual desire. Phenylethylamine is commonly known as the ‘love transmitter’ and is found in high levels in a number of foods, especially red wine and dark chocolate (or pure cocoa). The PEA chemical is rapidly degraded by MAO enzymes when taken orally and has a short half-life in the body. If required, LiftMode recommends taking Phenylethylamine in addition to Hordenine to allow for a longer lasting effect (up to 2 hours).

Phenylethylamine HCl occurs naturally in numerous species, including in a variety of algae and bacteria. Chemically, PEA is structurally very similar to tyramine, octopamine, and Hordenine. When found in nature (and in the human body), PEA is produced as a derivative of L-Phenylalanine.[2] According to estimates, the average Western diet contains roughly 4 grams of L-Phenylalanine per day. Only a small percentage of this is destined to be converted into Beta-Phenylethylamine.[3]

 

phenylethylamine-for-energy

Phenylethylamine HCL Effects & Benefits

 

1.     Phenylethylamine Dramatically Boosts Energy

 

The key reason why most people who take Phenylethylamine take it, is because of its ability to increase physical and mental energy so significantly. β-Phenylethylamine helps to improve energy through its interactions with catecholamine receptors. By increasing the rate of catecholamine release, PEA helps the brain to increase concentrations of epinephrine, norepinephrine and dopamine. [4]

Catecholamines are involved in what’s known as the ‘fight-or-flight’ response to stress.[5] These energizing neurotransmitters are generally released in response to signals from the brain that a threat is near. Catecholamines increase the heart rate and help to focus the mind while increasing physical energy. They are part of an ancient biological system to get you ready to deal with a threat – either by outrunning it or by fighting it. As you can imagine, hundreds of millions of years of evolution have proven ample time to produce a highly effective system for increasing energy!

What this means, is that when you take Phenylethylamine for energy enhancement, the levels of epinephrine, norepinephrine, and dopamine in your brain increase significantly. This ‘tricks’ your body into getting ready for strenuous exercise. The associated increase in dopamine means that you get a powerful energy boost without feeling stressed or agitated.

 

2.     Phenylethylamine Helps to Improve Mood

 

By helping the brain to release extra dopamine (the ‘feel-good’ hormone) and norepinephrine, PEA acts predominantly as an invigorating mood-enhancer, resulting in improved energy levels, a noticeable mood lift and euphoric sensations. As with most energizing supplements, the effects of PEA also include a mild appetite suppression. Phenylethylamine is found naturally in all animals and in very low concentrations (trace) and is considered to be highly potent. Furthermore, PEA boosts neurotransmitter signals to enhance cognitive function and mood, as reported in this 1990 study:

It boosts the signal strength of neurotransmitters by increasing their signal-to-noise ratio.  This means that PEA more efficiently couples the release of neurotransmitters to the electrical impulse that triggers their release.  The end result is that PEA cranks up the volume of neurotransmitter activity for higher performance throughout the body, and it does not matter how old you are to experience a noticeable performance improvement in daily activities”.[6]

A few important studies, like the one above, have explored the effects of Phenylethylamine on mood. Another example is a review published in 1995, which found that Phenylethylamine, being a neuromodulator of aminergic synapses, promotes energy and elevates mood, and significantly ‘improves mood in depressed patients treated with a selective monoamine oxidase B inhibitor’. [7]

 

3.     Phenylethylamine for Concentration and Learning

 

In research articles into the effects of PEA, it was found that people exhibiting ADHD symptoms had generally lower serum PEA levels than otherwise healthy people. Supplementing with Phenylethylamine may be able to reduce these effects and to increase concentration. Due to the release of the ‘feel-good’ hormone dopamine, PEA is associated with mood-lift and euphoria, even in stressful situations.

PEA (Beta-Phenylethylamine) benefits also include increased learning capacity:

PEA releases acetylcholine, a neurotransmitter that plays an integral role in learning and memory.  Brain receptors respond to acetylcholine by facilitating memory and higher cognitive functions.  In addition, PEA increases noradrenaline, the brain's version of adrenaline, which is required for alertness, concentration, and "get up and go."  An increase in glutamate from PEA can throw switches to the "on" position in memory-forming circuits, making it easier to form memories.[8]

 

4.     Other Potential Benefits

 

Firstly, there has been a fair amount of research conducted focussing on the potential use of PEA for reducing stress-related issues, and even some research looking into potential future development for reducing feelings of panic. In some regards, Phenylethylamine looks very promising as a research compound and for future development of PEA derivatives.[9]

Secondly, PEA is useful in anti-ageing research, due to its activity on catecholamines in the brain. As we get older, our catecholamine release system begins to degrade, causing reduced energy and lower moods. Phenylethylamine is able to rectify this by triggering the brain to release more catecholamines.[10] The theory is that this will help people who suffer from age-related cognitive difficulties, helping to improve mental focus and vitality.

Thirdly, the effects of PEA have been linked to what is commonly known as the ‘runner’s high’. A recent study found that healthy men who had undergone an intense 60-minute exercise programme had increased levels of PEA. PEA is thought to be what causes the common post-workout euphoria.[11]

Fourthly, it appears that Phenylethylamine may have the potential to be useful in managing addiction in future. Specifically, studies suggest that β-phenylethylamine receptors may be involved in the development of addiction and that β-phenylethylamine may have potential to be used as an ‘agonist therapy’ for substance addiction, in future.[12]

 

Phenylethylamine HCl and Trace Amine-Associated Receptors (TAARs)

 

Phenylethylamine is an amine-type compound, as the name suggests. Amines are derivatives of ammonia and include a wide range of very important compounds in biological systems, including amino acids, biogenic amines, trimethylamine, and inorganic amines like chloramine. A subset of naturally-occurring and synthesized amines called trace amines bind to receptors in the brain called trace amine-associated receptors (TAARs) or simply trace amine (TA) receptors.

β-Phenylethylamine is considered to be a trace amine and binds to a variety of TAARs.[13] Trace amine receptors are found in intracellular (inside the cells) membranes and respond to binding by trace amines. These include many neurotransmitters, like tyramine, tryptamine, Phenylethylamine, and others. The trace amine signalling pathway is considered important in the release of catecholamines (dopamine, epinephrine, and norepinephrine).[14]

The TAARs (trace amine receptors) are considered to be of major importance to the biochemical mechanisms of many entheogenic and hallucinogenic compounds. For this reason, many neuroscientists focus a lot of research into the biochemical pathways underlying trace amine receptor functions. There is also a theory that malfunctioning trace amine receptors are involved in a number of schizoid-related disorders.[15]

β-Phenylethylamine binds to TA1 and TA2 receptors at a high potency.[16] This may be a part of the mechanism involved in PEA’s ability to increase production of neurotransmitters while reducing their uptake. 

 

neurotransmitter-concept-for-pea

Phenylethylamine HCL Recommended Use

 

Phenylethylamine serving sizes range from around 100-500mg daily. Smaller servings will exhibit the base cognitive effects, while higher doses will bring on a more intense experience and the euphoric effects. Due to its stimulant effects, PEA is most often taken in the morning or around 30-40mins before exercise. It is not recommended to take PEA at night as it may interrupt sleeping patterns. [17]

 

Phenylethylamine HCL Side Effects and Warnings

 

As with all stimulants and energizing compounds, there are potential side effects to Beta-Phenylethylamine use. Adverse effects are generally dose dependent and are low risk. Side effects can include a headache and upset stomach.[18] Since PEA is a naturally occurring molecule, the body has a unique, fast and effective method of breaking it down so toxic overdose, even at very high dosages, is extremely unlikely. However, it is always recommended to stick to the suggested serving size.

According to a research article about teens using PEA in conjunction with other research chemicals at music festivals, acute overdosing may result in a negative mental state.[19] It is important to remember that these negative effects are short-lived due to the rapid metabolism of PEA, and have only been reported as caused by using PEA in conjunction with other chemicals.

It is important to stick to recommended doses and not overdo it, especially after taking Phenylethylamine supplements for a while. This is because of the tolerance that builds up. It is not recommended to take Phenylethylamine while using any medication, to prevent a risk of potentially dangerous interactions.

Some people do recommend using Hordenine with Phenylethylamine to prolong the effects, should it be required.[20] This is generally okay, but caution should be used when combining these two powerful compounds. Always start with lower serving sizes to get a feel for how your body responds, especially when combining supplements.

Another research article has found that Phenylethylamine supplements increase the effects of amphetamines.[21] It is not recommended to combine the two. Many amphetamine-like compounds have a similar effect to PEA, by releasing neurochemicals like dopamine or serotonin and inhibiting their uptake. It is quite common to see psychotic episodes from an overdose of amphetamines. Once again, it is important to remember that PEA has an extremely low half-life in the body and, unless used in conjunction with an MAOI, the overdose effects would most likely be very short-lived. [22]

Do not use this supplement without first speaking to your doctor if you have any underlying medical conditions or are using any medication. There is insufficient information about safety for pregnant and breastfeeding women at this time. 

 

Conclusion

 

In summary, this neurotransmitter and trace amine can be used as a powerful energizing dietary supplement. It is sometimes also called PEA, β-phenylethylamine (β-PEA), and 2-phenylethan-1-amine and plays a key role in the brain as a modulator of catecholamines, and it is synthesized from the amino acid L-phenylalanine. As a dietary supplement, PEA is used for its energizing and mood-lifting effects. Summarized benefits include mood-lift and increased energy, general feelings of well-being, and support for healthy cognition. 

This supplement has a fairly short half-life and effects tend to last for around 1-1.5 hours when taken alone. People often take Phenylethylamine with Hordenine to prolong and enhance the effects of these two energizing compounds. Taking these two supplements together may have a synergistic effect. The recommended serving size for PEA supplements is between 100 - 500 mg, preferably taken in the morning or around 45 minutes prior to exercise. Side effects from larger serving sizes may include headaches and upset stomach. Do not use this supplement if you are taking any medication or have any underlying medical conditions. 

Important: Phenylethylamine HCl is also sometimes referred to as PEA, β-phenylethylamine, phenethylamine, β-phenethylamine, and Benzeneethanamine. It is often misspelt as Phenethylamine.

 

phenylethylamine-learning-concept

References



[1] Shannon HE, Cone EJ, Yousefnejad D. Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. J Pharmacol Exp Ther. 1982 Oct;223(1):190-6.

[2] Silkaitis RP, Mosnaim AD. Pathways linking L-phenylalanine and 2-phenylethylamine with p-tyramine in rabbit brain. Brain Res. 1976 Sep 10;114(1):105-15.

[3] Janssen PA, Leysen JE, Megens AA, Awouters FH. Does phenylethylamine act as an endogenous amphetamine in some patients?  Int J Neuropsychopharmacol. 1999 Sep;2(3):229-240.

[4] Mesfioui A, et al. Effects of amphetamine and phenylethylamine on catecholamine release in the glomerular layer of the rat olfactory bulb. Biol Signals Recept. 1998 Jul-Aug;7(4):235-43.

[5] Kopin IJ. Catecholamine metabolism: basic aspects and clinical significance. Pharmacol Rev. 1985 Dec;37(4):333-64.

[6] “2-Phenylethylamine: A Modulator of Catecholamine Transmission in the Mammalian Central Nervous System?” I. A. Paterson,  A. V. Juorio and A. A. Boulton, Journal of Neurochemistry, Volume 55, Issue 6,  pages 1827–1837, December 1990

[7] Sabelli HC, Javaid JI. Phenylethylamine modulation of affect: therapeutic and diagnostic implications. J Neuropsychiatry Clin Neurosci. 1995 Winter;7(1):6-14.

[8] “The Science of PEA: The Brain's Natural Stimulant for Higher Performance and Longevity” Richard Clark Kaufman, PhD, online article, naturodoc.com accessed 11-12-2014

[9] “Does phenylethylamine act as an endogenous amphetamine in some patients?” Paul A. J. Janssen, Josée E. Leysen, Anton A. H. P. Megens, Frans H. L. Awouters, International Journal of Neuropsychopharmacology, 1999

[10] Pascualy M, Petrie EC, Brodkin K, Peskind ER, Veith RC, Raskind MA. Effects of advanced aging on plasma catecholamine responses to the cold pressor test. Neurobiol Aging. 1999 Nov-Dec;20(6):637-42.

[11] “Phenylethylamine, a possible link to the antidepressant effects of exercise?” A Szabo,  E Billett,  J Turner, Br J Sports Med  2001;35:342-343   doi:10.1136/bjsm.35.5.342

[12] Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.

[13] Sotnikova TD, et al. Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. J Neurochem. 2004 Oct;91(2):362-73.

[14] Pei Y, Asif-Malik A, Canales JJ. Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications. Front Neurosci. 2016; 10: 148.

[15] John J, Kukshal P, Bhatia T, Chowdari KV, Nimgaonkar VL, Deshpande SN, Thelma BK. Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia. Schizophr Res. 2017 Nov;189:190-195.

[16] Premont RT, Gainetdinov RR, Caron RG. Following the trace of elusive amines. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17): 9474–9475.

[17] Phenylethylamine, Examine.com, available online [Accessed December 15, 2017]

[18] Phenylethylamine Side Effects And Safety, WebMD.com, available online [Accessed December 15, 2017]

[19] Sanders B, Lankenau SE, Bloom JJ, Hathazi D. “Research Chemicals”: Tryptamine and Phenethylamine Use Among High-Risk Youth. Subst Use Misuse. 2008; 43(3-4): 389–402.

[20] Hoffman JR, et al. Thermogenic effect of an acute ingestion of a weight loss supplement. J Int Soc Sports Nutr. 2009; 6: 1.

[21] Safratowich BD, Hossain M, Bianchi L, Carvelli L. Amphetamine Potentiates the Effects of β-Phenylethylamine through Activation of an Amine-Gated Chloride Channel. J Neurosci. 2014 Mar 26; 34(13): 4686–4691.

[22]  “Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding.” E M Parker and L X Cubeddu, Journal of pharmacology, April 1988   vol. 245  no. 1  199-210

 

Reviews