- Rapid, powerful increased energy for up to 1-2 hours
- Strong Mood-lift which can last several hours
- Increased focus and endurance
Phenylethylamine HCL or Phenethylamine supplement powder is a trace monoamine found in all animals and plants that acts as a promoter of catecholamine (dopamine and norepinephrine) release.
The benefits of Phenylethylamine supplements include rapid, short-lasting, powerful mood-lift and increased energy, general feelings of well-being, increased learning capacity and may be partly responsible for the ‘runner’s high’.
Dosage of Phenyethylamine is recommended at around 100-500mg in the morning or 30-40mins before exercise. Side effects are dose dependant and may include high blood pressure, headaches, flushing, rash, anxiety and upset stomach. If used in combination with other stimulants, or MAOI / monoamine affecting medications, side effects may be more pronounced.
Phenylethylamine HCL reviews
“I ordered PEA with Hordenine after much research. My goal was to get some extra energy in the morning as it it sometimes difficult to wake up/get up. The combo seems to work but I have been very careful to follow the dosages outlined by liftmode. The danger is high BP and HR. I have not experienced this but be careful with this substance as it can act as a powerful stimulant of the body and mind if combined with an MAOB inhibitor.” – Brian, LiftMode Phenylethylamine review.
- Phenylethylamine is a trace monoamine found in all animals and plants that acts as a modulator of catecholamines
- The benefits of phenylethylamine supplements include mood-lift and increased energy, general feelings of well-being, increased learning capacity and is responsible for the ‘runner’s high’
- Dosage of phenyethylamine is recommended at around 100-500mg in the morning or 30-40mins before exercise
- Side effects are dose dependant and may include headaches and upset stomach. If used in combination with other stimulants, side effects may be more pronounced.
Phenylethylamine (PEA, Phenethylamine, Beta Phenylethylamine or 2 Phenylethylamine) is a naturally occurring trace monoamine, and a derivative of the amino acid phenylalanine. It is found naturally in all mammals in low levels and acts in various functions – most prominently as a promoter of catecholamine release (i.e. dopamine, norepinephrine and epinephrine) in the brain. It acts to release dopamine and norepinephrine, and thereby to act as a stimulant and mood-enhancer, as well as an appetite suppressor.
Online published personal reviews on the effects have found interesting additional mood enhancement from PEA use including a feeling of general well-being, creativity, awareness, attention and sexual desire. Phenylethylamine is commonly known as the ‘love drug’ and is found in high levels in especially dark chocolate (i.e. pure cocoa). The chemical is rapidly degraded by MAO enzymes when taken orally and has a short half-life in the body. Therefore, PEA has short lived effects, and can be variable from person to person. If too little PEA is consumed, no effect will result - and some people metabolize PEA so quickly that normal serving sizes of PEA will have no effect on their own. If too much PEA is consumed, overstimulation can occur, resulting in high blood pressure, headache and anxiety among other negative effects. Therefore, it is important to approach PEA with patience and caution to ensure finding the optimum serving size for your individual metabolism.
If required, LiftMode recommends taking Phenylethylamine in combination with Hordenine to allow a longer lasting effect (up to 2 hours).
Pure Phenylethylamine HCL effects / benefits
By acting to release dopamine (the ‘feel-good’ neurotransmitter) and norepinephrine (the ‘alertness’ neurotransmitter), Phenylethylamine or Phenethylamine powder acts predominantly as a stimulant and mood-enhancer producing energy, mood lift and euphoric sensations. As with most stimulants, the effects also include appetite suppression. Phenylethylamine is found naturally in all animals tested to date, in low concentrations, and is highly potent as a neurotransmitter in its own right. Like some other phenylethylamine derived molecules, PEA boosts neurotransmitter signals to enhance cognitive function.
“It boosts the signal strength of neurotransmitters by increasing their signal-to-noise ratio. This means that PEA more efficiently couples the release of neurotransmitters to the electrical impulse that triggers their release. The end result is that PEA cranks up the volume of neurotransmitter activity for higher performance throughout the body, and it does not matter how old you are to experience a noticeable performance improvement in daily activities.”(Boultan and Jourio, 1990)
PEA supplement is also useful in anti-aging due to its activity on catecholamines in the brain. As we get older, our catecholamine release system begins to degrade, resulting in lower energy and mood. PEA is able to rectify this by enhancing the release of catecholamines.
In research articles into the effects of PEA, it was found that people exhibiting ADHD symptoms had generally lower serum PEA levels than the norm. Supplementing with Phenylethylamine may be able to reduce distractibility and improve focus and concentration.
Due to the release of the ‘feel-good’ hormone dopamine, PEA is associated with mood-lift, energy and euphoria, even in stressful situations.
Phenyethylamine benefits also include increased learning capacity:
“PEA releases acetylcholine, a neurotransmitter that plays an integral role in learning and memory. Brain receptors respond to acetylcholine by facilitating memory and higher cognitive functions. In addition, PEA increases noradrenaline, the brain's version of adrenaline, which is required for alertness, concentration, and "get up and go." An increase in glutamate from PEA can throw switches to the "on" position in memory-forming circuits, making it easier to form memories.”(Kaufman, 2012)
There have been numerous reports of the use of PEA as a support for calm mood in contrast to the symptoms of acute anxiety disorders and panic attacks and it appears to be highly effective in this regard.
The effects of PEA have been linked to what is commonly known as the ‘runner’s high’. A recent study found that healthy men who had undergone an intense 60 minute exercise programme had increased levels of PEA. PEA is thought to be part of what causes the common post-workout euphoria.
Phenylethylamine HCL recommended dosage
Phenylethylamine doses range from around 100-500mg daily. Lower doses can exhibit the more subtle cognitive effects, while higher doses will bring on a more intense experience and euphoric energizing effects. Due to its stimulant effects, PEA is most often taken in the morning or around 30-40mins before exercise. It is not recommended to take PEA at night, as it may interrupt sleeping patterns.
PEA HCL side effects and warnings
As with all stimulants there are side effects to Phenylethylamine use. These are generally dose dependant and are usually mild at the recommended serving size. Side effects can include headache and upset stomach. If taken at higher than recommended amounts, or combined with other stimulants or MAOI / monoamine affecting medications, more serious side effects including high blood pressure, headaches, flushing, rash, anxiety and jitters can also occur. Since PEA is a naturally occurring molecule, the body has a unique, fast and effective method of breaking it down via monoamine oxidases, so toxic overdose is less likely.
According to a research article about teens using PEA in conjunction with other ‘research chemicals’ at music festivals, acute overdosing resulted in a negative mental state. It is important to remember that these negative effects are short-lived due to the rapid metabolism of PEA, and only caused by over-dosing and using PEA in conjunction with other chemicals.
It is important to stick to recommended doses and not overdo it, especially after taking it for a while because of the tolerance that builds up. It is also not recommended to take Phenylethylamine while using prescribed MAOIs, because these will inhibit the breakdown of the drug in the body. However, LiftMode does recommend using Hordenine to prolong the effects, should it be required.
Another research article has found that Phenylethylamine will increase the effects of amphetamines and users are not recommended to combine the two.
Most amphetamines have a similar effect to PEA, by releasing neurochemicals like dopamine or norepinephrine, and inhibiting their uptake. It is quite common to see psychotic episodes from overdose of amphetamines. Once again, it is important to remember that PEA has an extremely low half-life in the body and, unless used in conjunction with an MAOI, the overdose effects would most likely be short-lived.
 “Phenylethylamine” Nootriment.com retrieved 08-12-2014
 “2-Phenylethylamine: A Modulator of Catecholamine Transmission in the Mammalian Central Nervous System?” I. A. Paterson, A. V. Juorio and A. A. Boulton, Journal of Neurochemistry, Volume 55, Issue 6, pages 1827–1837, December 1990
 “The Science of PEA: The Brain's Natural Stimulant for Higher Performance and Longevity” Richard Clark Kaufman, PhD, online article, naturodoc.com accessed 11-12-2014
 “Does Phenylethylamine act as an endogenous amphetamine in some patients?” Paul A. J. Janssen, Josée E. Leysen, Anton A. H. P. Megens, Frans H. L. Awouters, International Journal of Neuropsychopharmacology, 1999
 “Phenylethylamine, a possible link to the antidepressant effects of exercise?” A Szabo, E Billett, J Turner, Br J Sports Med 2001;35:342-343 doi:10.1136/bjsm.35.5.342
 “Comparative effects of amphetamine, Phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding.” E M Parker and L X Cubeddu, Journal of pharmacology, April 1988 vol. 245 no. 1 199-210