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  • Promotes relaxation, pain relief, antioxidant and anti-inflammatory support
  • Helps maintain strong immune system
  • Over 1000 years of history


Baicalin is extracted from Skullcap, including Baikal Skullcap, and has been used in herbal Chinese medicine over many centuries for a number of vitality promoting effects and for healthful relaxation. Our Baicalin is extracted specifically from the root of Scutellaria baicalensis (Baikal Skullcap). Baicalin functions with a wide range of positive effects including aiding in pain relief, promotion of relaxation, anti-inflammatory support and antioxidant support. Baicalin may also help to support a healthy immune system.Recommended supplement doses range from around 60-250mg daily. After over 1000 years of use, there are very few side effects associated with Skullcap and Baicalin extracts.


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Baicalin reviews


Baicalin product reviews


  • Baicalin is extracted from the Blue Skullcap and has been used in herbal Chinese medicine for a number of health-promoting effects and promotion of relaxation


  • Baicalin functions include aiding in pain-relief, promotion of relaxation, anti-inflammation, as an antioxidant, with a wide range of other benefits


  • Recommended doses range from around 60-250mg daily 


What is Baicalin?


Baicalin is a remarkably healthful molecule extracted from several Skullcap species, including Scutellaria lateriflora (blue skullcap), Scutellaria galericulata (common skullcap), and Scutellaria baicalensis (Baikal Skullcap) and has been used in Chinese herbal medicine for over 1000 years. Our Baicalin is extracted specifically from the root of Scutellaria baicalensis (Baikal Skullcap). Baicalin is the glycoside of the flavone flavonoid baicalein, which is also found in the Skullcap species, and the two molecules have synergistic properties. Baicalin is known to exhibit a multitude of beneficial effects including pain-relief, anti-inflammatory, and antioxidant effects. Baicalin is commonly used for promotion of relaxation due to its effects on GABA type-A receptors.[1]


Baicalin effects / benefits


Baicalin supplementation has a wide variety of highly beneficial effects. Its use as an ethanol extract from the Skullcap plant species extends for over 1000 years in herbal Chinese medicine.  Baicalin can help to promote a feeling of healthy well-being, due to its effects on GABA subtype A receptors, but this is only one of many great things about using Baicalin.


Pain-relief and promotion of relaxation

Baicalin has been found to act selectively on GABA subtype A receptors, on the receptor allosteric modulating benzodiazepine (BZ) sites. This allows the chemical to create stress-reducing effects devoid of the sedation and muscle-relaxation that are characteristic of most GABA agonists.[2] GABA agonists that act on all subtype A receptors also generally cause alcohol-like effects including pain-relief, sedation, and muscle-relaxation, but Baicalin acts selectively on certain specific BZ subtype sites so it causes pain-relief and feelings of well-being without the side effects of sedation, memory impairment or tolerance.[3]



Baicalin has been found to work as an effective anti-inflammatory agent by inhibiting binding of leukocytes to chemokines and inhibiting cell migration (a characteristic cause of inflammation). It does not interfere directly with chemokines but rather binds to specific ligands to prevent chemokine-leukocyte binding. [4]


Anti-viral Research

Baicalin has been known for a long time in Chinese medicine to be capable of anti-viral effects. Recent Western scientific studies have indicated that this traditional knowledge may be more factual than once assumed. In some laboratory studies, this remarkable chemical has been shown to inhibit some virus replication and adsorption as well as producing virucidal effects against extracellular virus particles at medium to high therapeutic doses[5].  



Recent scientific studies into the effects of Baicalin use have confirmed that it is also an effective antioxidant. In a study on the antioxidant effects of Baicalin, baicalein, and wogonin (all extracts from Skullcap species), it was found that Baicalin was effective in reducing cytochrome c as well as eliminating superoxide free-radicals, testifying to its antioxidant nature.[7]


Baicalin recommended usage


From Examine.com:

Although there is a lack of human evidence to support the optimal dosage of scutellaria baicalensis for supplementation purposes, the doses that appear optimal in rat and mouse models suggest that an oral dose of around 500mg of the root extract should be efficacious.”

From a Baicalin patent application for antianxiety treatment:

According to the radio of body weight of mouse to that of human, the individual dosage of Baicalin for oral administration is 0.8-3.5mg/kg." (Hong et al., 2004)

In a 75kg person, the above recommended dose equates to 60-265mg daily


Baicalin side effects and warnings


Even through 1000 years of use in Chinese herbal medicine, Baicalin appears to have no negative side effects in humans even after using high doses. WebMD warns that gas, nausea or diarrhea may occur. Health Central warns that people should consult a physician before using Baicalin if they have a history of stomach ulcers. Both WebMD and Health Central have a warning about the possibility of an allergic reaction to Baicalin, which can include: yellowing of the eyes and skin, itchiness, rash and/or severe dizziness. (Examine). 




[1] “Scutellaria baicalensis” examine.com, accessed 12-12-2014

[2]  “New use of Baicalin for treating anxiety” WO 2004103386 A1, Pharmaco Genetics Ltd, Wang Zihui, Xue Hong, Zheng Hui, Dec 2, 2004

[3] “GABA A receptor subtype selectivity underlying the selective anxiolytic effect of Baicalin.” Wang F, Xu Z, Ren L, Tsang SY, Xue H., Neuropharmacology. 2008 Dec;55(7):1231-7

[4]  “The flavonoid Baicalin exhibits anti-inflammatory activity by binding to chemokines.” Li BQ1, Fu T, Gong WH, Dunlop N, Kung H, Yan Y, Kang J, Wang JM., Immunopharmacology. 2000 Sep;49(3):295-306.

[5] “Novel antiviral activity of baicalein against dengue virus” Sazaly Abu Bakar et al., BMC Complementary and Alternative Medicine 2012, 12:214 

[6]  “Flavonoid Baicalin inhibits HIV-1 infection at the level of viral entry.” Li BQ et al., Biochem Biophys Res Commun. 2000 Sep 24;276(2):534-8

[7] “Antioxidant and free radical scavenging effects of baicalein, Baicalin and wogonin” Shieh DE, Liu LT, Lin CC, Anticancer Research [2000, 20(5A):2861-2865]

[8] “Antitumor effects of Scutellariae radix and its components baicalein, Baicalin, and wogonin on bladder cancer cell lines” Ikemoto S, Sugimura K, Yoshida N, Yasumoto R, Wada S, Yamamoto K, Kishimoto T., Urology. 2000 Jun;55(6):951-5.

[9] “Antitumor effect of Baicalin on rat brain glioma” Hu YZ1, Wang DH, Luan Y, Gong HD., Zhonghua Zhong Liu Za Zhi. 2013 Jan;35(1):11-6.