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Buy Our Matrine Supplement


Sophora flavescens, often referred to as Ku Shen Gen or bitter root, is a well-regarded herb in traditional Chinese medicine with anti-inflammatory and neuroprotective effects. The alkaloid Matrine is one of the main constituents in the plant. It has the chemical formula  C15H24O2  and a molecular weight of 264.36 g/mol. 


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Matrine Benefits and Uses


Matrine is a water-soluble alkaloid extracted from Sophora flavescens, an evergreen shrub that grows in tropical climates. It is a popular nutraceutical and is commonly taken to improve immune function and liver health.


Sophora flavescens has been used as a herbal remedy in traditional Chinese medicine for many years, with therapeutic uses as an anti-inflammatory agent. Traditional practitioners used Matrine for its heat-reducing, damp-drying and diuretic effects. The herb also exhibits therapeutic effects on allergic reactions and promotes healthy skin function.


Sophora flavescens possesses over 16 bioactive compounds, of which the most prominent is the alkaloid matrine and its related compounds oxymatrine and sophoridine.  Matrine is also found in other plant species of the Sophora family.


Anecdotally, Matrine may offer some important anti-inflammatory benefits. Studies indicate Matrine supports immune function by mediating proinflammatory mechanisms in the body. What’s more is Matrine promotes restful sleep and relaxation and has purported anti-nociceptive effects, (pain-relief), anti-viral and antioxidant effects. As a natural anti-parasitic, It is often stacked with other similar supplements like Artemisia.


Where to Buy Matrine Online?

LiftMode offers a variety of unit sizes of Matrine extract including -gram (Oz) and -gram (Oz) units. LiftMode Matrine is guaranteed 98% (Sophora flavescens) pure.

All our products ship with a certificate of analysis from 3rd-party independent laboratories and all orders are covered by our 90-days refund/reshipment policy to ensure the highest quality.


Shipping restrictions: No shipping restrictions currently apply to this product and we are able to ship internationally. At checkout, the available shipping options for your location will be available.




Matrine supplements are also known by a few different names, including:

Yellow sophora root

Sophora flavescens

Yellow Pagoda Tree

Bitter root


Ye Huai Gen

Ku Shen Gen

Ku Shen Jian



Scientific Consensus:


Matrine extract is considered safe and effective when taken in recommended doses.


There has been a reported case of liver in a study showing Matrine may have hepatotoxic effects, i.e. can damage the liver. In contrast, another study indicated matrine has no toxic effects on the liver. Hence, the available data regarding the herb’s side effects is confusing and should be subject to further research.


There is not enough data to say whether Matrine is safe for pregnant or breastfeeding women, or if it can be used by children.




All dietary supplements have risks. Please ensure that you are familiar with the latest research on effects, side effects, benefits, and uses of a supplement before buying it.


Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions or are taking any medication, especially blood thinners or sleeping aids, please consult a medical professional before using this supplement. 


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

buy matrine online




  • National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 114850, Oxymatrine. Retrieved August 18, 2020 from 

  • Wang H, et al. (2012) Comparative analysis of quinolizidine alkaloids from different parts of Sophora alopecuroides seeds by UPLC-MS/MS. J Pharm Biomed Anal.

  • Li K, Wang H. (2004) Simultaneous determination of matrine, sophoridine and oxymatrine in Sophora flavescens Ait. by high performance liquid chromatography. Biomedical Chromatography, 18(3):178-82

  • Yuan Jing, Zhang Zong-jian, Cong Bin. Biological activity of matrine and its research progress. Pesticides. 2003;42(7):1–4.

  • Lee, H. J., Lee, S. Y., Jang, D., Chung, S. Y., & Shim, I. (2017). Sedative Effect of Sophora flavescens and Matrine. Biomolecules & Therapeutics, 25(4), 390–395.