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Buy Our Piperine (Black Pepper Extract) Supplement


Piperine (or Piperaceae) is the active compound in black pepper. Piperine is used for its ability to inhibit phase 2 detoxifying enzymes and to prevent the process of glucuronidation. It has the chemical formula ‎C17H19NO3 and a molecular weight of 285.343 g/mol.


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Piperine Reviews


Piperine Benefits and Uses


Piperine has the ability to significantly improve the absorption and uptake of many dietary supplements. It has significant and profound effects on metabolic enzymes in the liver and intestine.


It may induce alterations in membrane dynamics and permeation characteristics, along with an increase in absorptive surface area in the small intestine. This supplement affects the P-glycoprotein-mediated efflux system, via modulation of functional activities and gene expression of P-Glycoprotein. Some research has pointed to a dose-dependent increase in gastric acid secretion and a delay in gastrointestinal motility.


Where to Buy Piperine Online?


LiftMode offers a bulk unit size of Piperine at 10 grams (0.35 Oz). Our Black Pepper extract supplement is guaranteed at a high purity of > 95%.


All our products ship with a certificate of analysis from 3rd-party independent laboratories, and all orders are covered by our 90-days refund/reshipment policy to ensure the highest quality.


Shipping restrictions: No shipping restrictions currently apply to this product and we are able to ship internationally. At checkout, the available shipping options for your location will be available.  




Piperine is known by a number of alternative names, including:







Black Pepper extract

Extrait de Poivre

Grain de Poivre

Piper nigrum


Peppercorn extract


Scientific Consensus:


Piperine the active compound in black pepper. It is used especially for its ability to downregulate or inhibit phase II detoxification enzymes and prevent the glucuronidation process in the liver. It allows certain supplements (especially water-soluble supplements that are metabolized by your liver) to be better absorbed.


When taken at the recommended serving size, Piperine is considered likely safe for use by most people. However, it is extremely important to note that Piperine interacts with almost every medication imaginable – especially medicines metabolised in the liver.


Warning: There is not enough research about the safety of Piperine for pregnant and breastfeeding women. Do not use this supplement if you have any underlying medical conditions.


Special Warning:


DO NOT TAKE PIPERINE SUPPLEMENTS IF YOU ARE TAKING ANY MEDICATION. If you are taking any medication, it is very important that you first speak to your doctor before using this supplement.


Piperine may also affect the metabolism of other dietary supplements, and it is recommended to using lower-than-usual servings if using other supplements in combination with Piperine.




All dietary supplements have risks. Please ensure that you are familiar with the latest research on effects, side effects, benefits, and uses of a supplement before buying it.


Store in a cool, dry place. Keep out of reach of children. If you have any underlying medical conditions or are taking any medication, please consult a medical professional before using this supplement. 


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

buy piperine black pepper extract


How We Research Our Content

Our content is written using meticulous research methods and claims are backed by links to scientific references, wherever possible. The author and editors of Liftmode's Research Team have strong academic backgrounds in microbiology, physiology, and biochemistry.

Content Updated On: November 19, 2019




  • Rao, V. R., Raju, S. S., Sarma, V. U., Sabine, F., Babu, K. H., Babu, K. S., Rao, J. M. (2011). Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. Nat Prod Res. 25(13):1288-94.


  • Martins, C.A., Leyhausen, G., Volk, J., Geurtsen, W. (2015). Curcumin in Combination with Piperine Suppresses Osteoclastogenesis In Vitro. J Endod.;41(10):1638-45


  • Srinivasan K. (2007). Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 47(8):735-48.


  • Srinivas, N.R. (2010). Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 40(5):357-67