- Potent antioxidant
- Supports healthy stress levels
- Supports healthy circulatory system>
Quercetin (or Quercitin) is a flavanoid found in many foods and vegetables with potent antioxidant properties. Polyphenol with multiple benefits including reducing histamine-mediated inflammatory response, protecting healthy heart function, supporting healthy blood pressure, supporting healthy cortisol production (stress relief), and has even been studied for its effects against cancer cells in the lab. Serving size of Quercetin is recommended at between 150-500mg daily. Side effects are uncommon and can include headaches and tingling in arms and legs at high doses.
“After years of getting spotty relief of allergy symptoms from over the counter allergy products, I stumbled over information for Quercetin. I am astonished at the relief of symptoms I get from this product. I'm a fan. Another winner from Liftmode.” – John, LiftMode review
“I have noticed that this seems to subtlety help with energy/endurance, but I feel I am getting more benefits with regard to my hay fever. It seems like it may also slightly be helping with my asthma as well, but that very well could be placebo. Like many supplements, these may take time to start really feeling the benefit. I take this with Baicalin and it does seem to help with my allergies.” – JW, LiftMode review
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- Quercetin is a flavanoid found in many foods and vegetables with potent antioxidant properties.
- Quercetin is an antioxidant with multiple benefits including antihistamine properties, protection of the heart against lipids and cholesterol, lowering systolic blood pressure, antihypertensive effects, reduction of cortisol production (stress relief) and even protection against some forms of cancerous cells.
- Dosage of quercetin is recommended at 150-500mg daily
What is Quercetin?
Quercetin is a naturally occurring polyphenolic bioflavonoid plant pigment that is found in many foods, including fruits, vegetables, grains, olive oil and red wine. It is probably the most studied flavonol. The best known benefit of Quercetin supplementation is its antioxidant effect, which helps to neutralize harmful free radicals in the body. Other benefits include supporting respiratory health (by reducing histamine-related inflammatory responses), supporting cardiovascular health, stabilizing normal blood pressure, reducing cortisol, supporting endurance and energy, and promoting general good health. Quercetin is often sold online as a stack containing a Quercetin bromelain complex. Bromelain is a protease found in pineapple, with anti-inflammatory properties.
Quercetin effects / benefits
One of Quercetin’s major roles is as an anti-inflammatory agent. Histamine is produced by the body’s immune system in reaction to allergic substances like pollen, dust, animal hair and airborne bacteria. It results in the typical cold-like symptoms or hay fever, i.e. red, swollen eyes, puffy cheeks and a runny nose. Quercetin has been found to be able to lower redness and photosensitivity in red skin and can help support a healthy non-inflammatory response to environmental agents which can trigger inflammation or allergies for some people.
“...flavonoids are potent anti-oxidant and anti-inflammatory compounds with mast cell inhibitory actions. Here, we first compared the flavonoid Quercetin (Que) and cromolyn on cultured human mast cells. Quercetin and cromolyn (100 µM) can effectively inhibit secretion of histamine and PGD(2).” (Antoniou C et al., 2012)
Another major benefit of Quercetin is its effects in cardiovascular protection. A large body of research has found that Quercetin is able to protect the heart by encouraging blood flow as well as protecting against LDL oxidation. Low-density lipoproteins (LDL) are responsible for many major forms of cardiovascular disease. LDL includes cholesterol, phospholipids and triglycerides. Oxidation of LDL in arteries can cause major heart problems.
“The metabolites of Quercetin show partial protective effects on endothelial function and LDL oxidation. Quercetin produces undisputed antihypertensive and antiatherogenic effects, prevents endothelial dysfunction and protects the myocardium from ischemic damage.” (Perez-Vizcaino F, Duarte J., 2010)
Another major benefit of Quercetin supplementation is its ability to stabilise blood-pressure as well as support healthy cholesterol levels. In 2009, a 6-week double-blind placebo study on 93 overweight and obese adults found that supplementation with Quercetin lowered systolic blood-pressure as well as HDL-cholesterol serum levels for the entire group. This study also correlated with previous findings that Quercetin is able to lower serum LDL levels by preventing LDL oxidation (antioxidant effects). 
This is especially relevant in Western cultures where there is a huge problem with obesity and high cholesterol levels. According to the Centre for Disease Control in the US, up to 71 million adults in the US (33.5%) have high levels of LDL. Of these, only one third has the condition under control, and the average total cholesterol level for Americans is close to 200mg/dl, which is borderline high risk.
Cortisol is commonly known as the ‘stress-hormone’ and its excess release produces negative effects in response to stress, including high-blood pressure, headaches, tiredness and a general feeling of negativity. Quercetin, in large amounts, has been found to be able to inhibit the expression of a critical gene in the synthesis of cortisol. This is what gives it its anti-stress properties. Lower stress generally means a better general feeling of good health.
There has been a lot of recent research into Quercetin use against cancer development and as protection against cancer formation. One study found that Quercetin was effective in inhibiting cell growth and producing apoptosis in castration-resistant human prostate cancer cells.
Another study found that PEGylated liposomal Quercetin was able to induce apoptosis (cell dormancy) in ovarian cancer cells. Some forms of ovarian cancer are resistant to cisplatin, and it was found that the PEGylated liposomal Quercetin induced apoptosis in both cisplatin-sensitive and cisplatin-resistant ovarian cancer cells.
Finally, there has been a lot of debate in scientific circles about whether or not Quercetin is actually able to boost energy levels and increase performance on its own. A 2009 study at the University of South Carolina on 12 healthy subjects, where half were given Quercetin and the rest a placebo, found that Quercetin supplementation boosts both endurance and VO2 max levels significantly. Subjects were given daily doses of 500mg Quercetin over seven days and endurance and VO2 max levels were monitored.
“The results: After taking Quercetin for only seven days, the participants had a 13.2 percent increase in endurance and a 3.9 percent increase in VO2max.” (M Davis et al., 2009)
Quercetin recommended dosage
Quercetin serving size is set at between 150-500mg daily. LiftMode Quercetin is 95% pure and is sold in a 50gram resealable container with a 0.625cc measuring scoop - measuring approximately 250 mg Quercetin per Scoop.
A 2009 study found that after 6 weeks of daily 150mg doses of Quercetin, liver and kidney function, haematology and serum electrolyte levels were all completely unaffecte, indicating that regular medium level supplementation is safe.
Quercetin side effects and warnings
Quercetin is considered as safe in normal doses of around 150-500mg per day. Side effects of large doses can include headaches and tingling in arms and legs.
 “6 Health Benefits of Quercetin” Global Healing Centre website, September 2013, accessed 2014-12-12
 “Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.” S Asadi et al., PLoS One. 2012;7(3)
 “Flavonols and cardiovascular disease” Perez-Vizcaino F, Duarte J. Mol Aspects Med. 2010 Dec;31(6):478-94. doi: 10.1016/j.mam.2010.09.002. Epub 2010 Sep 15
 “The role of Quercetin, flavonols and flavones in modulating inflammatory cell function.” Chirumbolo S., Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85.
 “Cholesterol” CDC website, accessed 2014-12-12
 “Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.” Cheng LC1 and Li LA, Toxicol Appl Pharmacol. 2012 Feb 1;258(3):343-50. doi: 10.1016/j.taap.2011.11.017. Epub 2011 Dec 8.
 “Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells.” Wang G, Song L, Wang H, Xing N, Oncol Rep. 2013 Jul;30(1):357-63. doi: 10.3892/or.2013.2469. Epub 2013 May 15
 “Induction of apoptosis and inhibition of angiogenesis by PEGylated liposomal Quercetin in both cisplatin-sensitive and cisplatin-resistant ovarian cancers.” Chen L et al, J Biomed Nanotechnol. 2013 Jun;9(6):965-75.
 “Arnold School study reveals benefits of Quercetin” Dr. Mark Davis et al, online article University of South Carolina media relations, June 2009
 “Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study” Egbert et al, Br J Nutr. 2009 Oct;102(7):1065-74.
 “Quercetin” WebMD, accessed 2014-12-12