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Rutin Extract

  • Supports a Healthy Circulatory System
  • Powerful Anti-inflammatory
  • Natural Bioflavonoid Antioxidant

 

Rutin (also known as rutoside, quercetin-3-O-rutinoside, sophorin, and Vitamin P) is a powerful and effective natural supplement for promoting health. It is found in numerous plant species, including most fruits and vegetables, and other well-known herbs like Ginko Biloba and St. John’s wort. It is a powerful compound for supporting a healthy circulatory system and acts as a potent antioxidant and anti-inflammatory. Some studies have shown that is may have immune-supporting benefits and may be useful in promoting healthy skin.


The recommended serving size is 500 mg, taken once to twice per day. Do not exceed the serving suggestion. Some people experience mild allergies, and side effects of large servings can include blurred vision, stomach upset, and headache. Consult your doctor before using if you are taking any medication (especially for blood-thinning). Do not use this supplement if you are pregnant or breastfeeding.

 

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Rutin Reviews

 

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  • A ubiquitous flavonoid compound found in many plant species and useful in providing a slow-release form of Quercetin
  • Benefits include support for a healthy circulatory system, as well as powerful antioxidant and anti-inflammatory effects
  • Recommended serving size is 500 mg, taken once to twice daily
  • Side effects may include blurred vision, stomach upset, and headache. Do not exceed the recommended serving size.

 

Background

 

Rutin (Vitamin P, rutoside, quercetin-3-O-rutinoside, sophorin, 3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside) is a natural flavonoid compound found in a number of plant species, including Ziziphus Jujuba leaves, blueberries, grapes, onions, peppers, and many other fruits and vegetables. [1] Rutin is chemically very similar to Quercetin. It consists of a Quercetin molecule bound to a rutinose sugar compound and is almost always found alongside Quercetin in plant extracts. In the body, Rutin acts as a deliverer for Quercetin to the large intestine. In the large intestine, the supplement is metabolised by microflora (natural gut bacteria) to liberate Quercetin, which acts as the active compound.[2]

One of the key benefits of this supplement is its ability to provide a ‘slow-release’ form of Quercetin. When it reaches the large intestine, gut bacteria metabolise the supplement to release Quercetin, which takes some time. In contrast to Quercetin supplements, which tend to have a fairly short half-life, this supplement has a long release time, giving you health benefits over a sustained period.[3]

As a result of its ubiquitous occurrence in herbs, fruits, and vegetables, this powerful health-promoting flavonoid has been used for hundreds (possibly thousands) of years in traditional remedies, by many different societies. It is found in numerous well-known herbs and plant extracts such as buckwheat, Japanese pagoda tree, Eucalyptus, lime tree flowers, elder flowers, hawthorn, rue, St. John's Wort, Ginkgo, apples, and other fruits and vegetables.[4] Furthermore, this compound is included in over 130 registered therapeutic medical preparations.[5]

Numerous studies have been conducted on this fascinating plant-based health compound. According to a recent review of the literature, it possesses a number of health benefits, including antioxidant, cytoprotective, vasoprotective, neuroprotective and cardioprotective effects.[6] It is considered to be a ‘vital phytochemical’ and is one of the most important active compounds that confer health benefits of fruits and vegetables – which doctors now recommend eating at least 8 – 10 servings of, per day.[7]

 

rutin-foods-best

Rutin Effects & Benefits

 

1.     Helps to Support a Healthy Circulatory System

 

One of the primary benefits of this supplement is the ability to help support a healthy circulatory system. It achieves this through a number of biochemical processes in the body aimed at supporting good health. One study found that isolated extracts from the Korean Dendropanax morbifera plant helped against thrombosis and coagulation in mice – helping to promote blood flow.[8]

In another study, researchers examined the effects of this supplement on cholesterol levels in rats with hypercholesterolemia. The results showed that, after 4 weeks of supplementation, total cholesterol levels and LDL-cholesterol had significantly declined.[9] In a similar study, this time involving 50 human diabetic participants, researchers again found that 60 days of supplementation, LDL-cholesterol had decreased, while HDL-cholesterol (so-called “good” cholesterol) had increased.[10]

A recent review of the literature took into account all previous studies with relevance to health benefits on the circulatory system. The numerous in vitro and in vivo studies all point towards beneficial effects on heart health, especially through antioxidant and anti-inflammatory processes.[11] Finally, a 2008 study published in the Journal of Angiology examined the effects of this supplement on circulatory health, over 5 years of supplementation. Results pointed to a partially serving size-related improvement in circulatory health, overall.[12]

 

2.     Powerful Anti-Inflammatory Benefits   

 

The beneficial effects of this supplement on health are believed to be strongly related to its antioxidant and anti-inflammatory effects. Several in vitro and in vivo (in living specimens) studies have confirmed this supplement’s powerful anti-inflammatory effects.[13] Inflammation alone is not necessarily a bad thing. Inflammation is the body’s response to illness and is a sign of a healthy immune system. However, certain conditions, including stress, unhealthy diets, and a lack of exercise can lead to an overworked immune system and too much inflammation in the body. This has several negative effects on health, which is why anti-inflammatories are so often recommended.[14]

The anti-inflammatory effects of plant flavonoids – like this supplement, for example – are well established. However, it is not always possible to consume the recommended 8 – 10 servings of fruits and vegetables per day, which is when an anti-inflammatory supplement like Rutin becomes useful. Studies have suggested that this supplement acts on the ‘High mobility group box 1’ (HMGB1) protein, which is involved in inflammation in the body. By inhibiting its activity, this supplement helps to reduce inflammation in the body.[15]

 

3.     Natural Bioflavonoid Antioxidant

 

Antioxidants are responsible for destroying harmful reactive ‘free-radical’ chemical in the body. These are produced through natural metabolic processes, but can occur in high concentrations as a result of ill health, poor diets, lack of exercise, environmental pollution, and lifestyle choices like smoking or drinking excessively. The human body has a number of complex systems in place to destroy natural free-radicals so that they don’t cause any harm. However, too many can be harmful to your health, especially if they react with DNA in the cell nucleus.

As an antioxidant, this supplement helps to prevent the dangerous activity of free-radicals produced in the body. In one study, the antioxidant effects of this supplement were compared to those of ascorbic acid (vitamin C) – a well-known natural antioxidant vitamin. The results showed that this supplement was slightly more effective than Vitamin C as an antioxidant.[16]

In another study, researchers examined the antioxidant effects of Rutin on mice exposed to Gamma radiation. Radiation is well-known to cause the body to produce very large amounts of free-radicals. The study found that this supplement was able to inhibit most free-radical species produced by the radiation and to prevent oxidative stress, indicating its efficacy as a natural antioxidant supplement.[17]

 

4.     Supports a Healthy Immune System

 

A few studies have examined the effects of this supplement on the immune system and immune function. Results point towards its ability to help support healthy immune function. In one study, rats were given Cyclosporine – an immunosuppressant toxin – to better elucidate the potential of the flavonoid to enhance and protect immunity. The results showed that both Quercetin and Rutin reduced the immunosuppressant activity of the toxin by over 50%. [18]

In a similar study, the immunity-enhancing effects of this supplement were explored in experimental animal models. Factors like cellular immunity and humoral immunity were monitored and assessed. The results showed a significant increase in antibody concentration, as well as enhanced immunoglobulin levels. In animals treated with an immunosuppressant toxin, the function of leucocytes was restored.[19]

 

5.     May Help Promote Healthy Skin  

 

Oxidative stress (a result of free-radicals) has long been associated with the ageing process in skin. Exposure to UV radiation from sunlight causes the production of free-radicals in the skin, which is believed to speed the ageing process.[20] That’s why antioxidants are often considered as being useful for promoting healthy skin and for reducing the signs of ageing. In one study, researchers examined the effects of this supplement on ageing in human dermal fibroblasts and human skin cells. For the in vivo experiment, a Rutin-containing cream was applied to the skin on 40 participants aged between 30 - 50 years, for a period of 4 weeks.

A number of factors were assessed, including dermal density, skin elasticity, the length and area of crow's feet, and the number of under-eye wrinkles. The results showed that the natural flavonoid increased the mRNA expression of collagen and had pronounced antioxidant activity in dermal cells. At the end of the study, overall skin elasticity was enhanced, and the length, area and number of wrinkles decreased – demonstrating the protective effects on skin ageing as a result of free-radical oxidation.[21] As yet, there are no studies to assess the effectiveness of oral Rutin on skin ageing. 

 

rutin-for-mood-healthy

Rutin Recommended Usage

 

According to clinical studies performed with this flavonoid compound, the best serving size for this supplement appears to be around 500 mg, taken once to twice daily. This serving size provides enough of the active compound to produce all health benefits associated with its use.

We do not recommend exceeding the suggested serving size. Rutin may go well when taken alongside a Quercetin supplement, and its bioavailability may be enhanced through the use of Piperine. If you’re planning on taking this supplement in a stack, always reduce the serving size and assess the efficacy before increasing it again.

 

Rutin Side Effects & Warnings

 

Rutin is a very powerful natural flavonoid compound and it is not recommended to exceed the suggested serving size. At large servings, side effects may include blurred vision, stomach upset, headache, flushed skin, rashes, nervousness, changes in heartbeat, and muscle stiffness.[22]

There may be a risk of allergy when using this supplement. If you experience rash-like symptoms, discontinue use immediately. There is evidence that suggests this supplement may act as a blood-thinner.[23] If you have a history of heart disease or blood clots or are on blood thinners, do not use this supplement without first consulting your doctor.

It is not recommended to use this supplement if you are taking any medication. This supplement may not be safe for pregnant or breastfeeding women as there is currently insufficient research to support its use.

 

Conclusion

 


In summary, this fascinating plant-based compound has a host of health-promoting benefits. It has been used in traditional healing remedies for hundreds of years and is a listed ingredient in over 130 registered therapeutic medical preparations. The supplement is metabolised by gut bacteria in the large intestine, where it provides a slow-release form of Quercetin. Its key benefits include support for a healthy circulatory system as well as potent antioxidant and anti-inflammatory effects. Rutin may also help support a healthy immune system and could help promote healthy skin. Overall, it is considered one of the top health-promoting natural compounds available today.

The recommended serving size is 500 mg, taken once to twice per day. Do not exceed the serving suggestion for this supplement. Some people have reported experiencing allergies after taking this supplement. It may not be safe for people with blood coagulation problems, or for people using blood-thinning medication. Do not use this supplement if you are pregnant or breastfeeding. Consult your doctor before using if you are taking any medication.

 

rutin-chemical-structure

References

 



[1]Quercetin”, Examine.com, available online from https://examine.com/supplements/quercetin/ [Accessed June 26, 2018]

[2] Kim H, Kong H, Choi B, Yang Y, Kim Y, Lim MJ, Neckers L, Jung Y. Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharm Res. 2005 Sep;22(9):1499-509.

[3] Jaganath IB, Mullen W, Lean ME, Edwards CA, Crozier A. “In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites.” Free Radic Biol Med. 2009 Oct 15;47(8):1180-9.

[4]Rutin”, WebMD.com, available online from https://www.webmd.com/vitamins/ai/ingredientmono-270/rutin [Accessed June 26, 2018]

[5] Chua LS. “A review on plant-based rutin extraction methods and its pharmacological activities.” J Ethnopharmacol. 2013 Dec 12;150(3):805-17.

[6] Ganeshpurkar A, Saluja AK. “The Pharmacological Potential of Rutin.” Saudi Pharmaceutical Journal : SPJ. 2017;25(2):149-164.

[7] Aune D, Giovannucci E, Boffetta P, Fadnes LT, Keum N, Norat T, Greenwood DC, Riboli E, Vatten LJ, Tonstad S. “Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies.” International Journal of Epidemiology. 2017 June; 46(3):1029–1056

[8] Choi JH, Kim DW, Park SE, Lee HJ, Kim KM, Kim KJ, Kim MK, Kim SJ, Kim S. “Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille.” J Biosci Bioeng. 2015 Aug;120(2):181-6.

[9] Ziaee A, Zamansoltani F, Nassiri-Asl M, Abbasi E. “Effects of rutin on lipid profile in hypercholesterolaemic rats.” Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):253-8

[10] Sattanathan, K & Dhanapal, C.K. & Manavalan, R. “LDL Lowering properties of rutin in diabetic patients.” International Journal of Pharma and Bio Sciences. 2010;1(4):467-473.

[11] Habtemariam S, Lentini G. “The Therapeutic Potential of Rutin for Diabetes: An Update.” Mini Rev Med Chem. 2015;15(7):524-8.

[12] Belcaro G, Cesarone MR, Ledda A, Cacchio M, Ruffini I, Ricci A, Ippolito E, Di Renzo A, Dugall M, Corsi M, Marino Santarelli AR, Grossi MG. “5-Year control and treatment of edema and increased capillary filtration in venous hypertension and diabetic microangiopathy using O-(beta-hydroxyethyl)-rutosides: a prospective comparative clinical registry.” Angiology. 2008 Feb-Mar;59 Suppl 1:14S-20S

[13] Guardia T, Rotelli AE, Juarez AO, Pelzer LE. “Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.” Farmaco. 2001 Sep;56(9):683-7.

[14]13 Ways Inflammation Can Affect Your Health.” Health.com, available online from http://www.health.com/health/gallery/0,,20898778,00.html [Accessed June 26, 2018]

[15] Yoo H, Ku SK, Baek YD, Bae JS. “Anti-inflammatory effects of rutin on HMGB1-induced inflammatory responses in vitro and in vivo.” Inflamm Res. 2014 Mar;63(3):197-206.

[16] Yang J, Guoa J, Yuan J. “In vitro antioxidant properties of rutin.” LWT - Food Science and Technology. 2008 July; 41(6):1060-1066

[17] Patil SL, Mallaiah SH, Patil RK. “Antioxidative and radioprotective potential of rutin and quercetin in Swiss albino mice exposed to gamma radiation.” Journal of Medical Physics / Association of Medical Physicists of India. 2013;38(2):87-92.

[18] Yu CP1, Wu PP, Hou YC, Lin SP, Tsai SY, Chen CT, Chao PD. “Quercetin and Rutin Reduced the Bioavailability of Cyclosporine from Neoral, an Immunosuppressant, through Activating P-Glycoprotein and CYP 3A4.J Agric Food Chem. 2011 May 11;59(9):4644-8

[19] Ganeshpurkar A, Saluja AK. “Protective effect of rutin on humoral and cell mediated immunity in rat model.” Chem Biol Interact. 2017 Aug 1;273:154-159.

[20] Poljšak B, Dahmane R. “Free Radicals and Extrinsic Skin Aging.” Dermatology Research and Practice. 2012;2012:135206.

[21] Choi SJ, Lee SN, Kim K, Joo da H, Shin S, Lee J, Lee HK, Kim J, Kwon SB, Kim MJ, Ahn KJ, An IS, An S, Cha HJ. “Biological effects of rutin on skin aging.” Int J Mol Med. 2016 Jul;38(1):357-63.

[22]The Potential Health Benefits of Rutin.” Healthline.com, available online from https://www.healthline.com/health/potential-benefits-of-rutin [Accessed June 27, 2018].

[23] Sheu JR, Hsiao G, Chou PH, Shen MY, Chou DS. “Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets.” J Agric Food Chem. 2004 Jul 14;52(14):4414-8.

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