Lift Mode

BaiCalm (Baicalein Complex) Sample

Regular price $3.68
Regular price $0.00 Sale price $3.68
Unit Size: 8ct
SKU: SAMPLE-BAI-CALM-C008

Free sample with any purchase – use code FREEBIE at checkout
Serenity without sedation.

A research-driven supplement intended to soften life’s edges, tame tension, and promote meditative clarity: BaiCalm is calm you can feel.

Description

Containing an HPLC-verified, synergized stack of bioactive, GABAergic, tranquility-promoting plant extracts, Baicalm is an ‘Advanced Calm Complex’: masterfully formulated for superior bioavailability, delivering noticeable calm, and a heightened sense of well-being.

How it Works: Gabaergic compounds and nervous system regulation

The inhibitory signaling of GABA (γ-Aminobutyric acid) via binding and activation of GABA receptors is a key messaging system a healthy central nervous system could utilize potentially to reduce neuronal excitability and regulate emotions such as fear, panic, or intense stress. Developed via our three pillar methodology, the BaiCalm formula starts with a research-driven, synergized stack of potent, natural GABAergic compounds.

Pillar 1: GABAergic Synergy – 3 Calming Plant Extracts

> Scutellaria Baicalensis Extract [Std. to ≥98% Baicalein]

Baicalein (5,6,7-trihydroxyflavone) is a potent flavonoid from Skullcap (S. Baicalensis), with a long history of use in Traditional Chinese Medicine. 2-3x more bioavailable than baicalin, a wealth of studies have asserted strong GABAergic activity of baicalein via modulation of the brain’s benzodiazepine site of the GABA-A receptors. This subtle but noticeable downshift of neuronal response to ‘fight or flight’ supports serenity without sedation – so you can wind down without tuning out.

Not only a long-term LiftMode favorite for calming nerves, baicalein is a potent antioxidant and has been extensively researched for a myriad of other ways in which it can promote wellbeing – including activities as a neuroprotective, a promoter of circulatory health, and supporter of an upbeat and resilient mood – each potentially enabled by gentle downregulation of cytokine signaling throughout the brain and body.

> Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol]

Baicalm’s Magnolia Bark Extract (M. Officianalis), favored in TCM as a soothing relaxant, contains a ≥95% concentration of powerful bioactive neolignan constituents magnolol and honokiol. Synergizing with baicalein, these neuroprotective compounds have both been shown to enhance GABAergic neurotransmission, binding to and positively modulating GABA-A receptors.

Research continues to explore other positive effects of magnolol and honokiol, beyond their impact on mood-regulating serotonin receptors and stress-related catecholamines. Magnolia bark extract may continue to be a popular natural remedy for not only calming, but also as a supplement to enhance mood, reduce stress and support an overall sense of reassurance and wellbeing.

At LiftMode, we call it “the BaiCalm glow”.

> Sinomenium Accutum Extract [Std. to ≥98% Sinomenine HCL]

Extracts of the plant Sinomenium acutum have a long history of use in Japan, China and Korea as traditional medicine for stabilizing mood, easing discomfort and soothing various aches and pains. Only recently have researchers begun to explore this natural extract’s primary alkaloid (Sinomenine) and its relaxing and relieving properties, with animal trial results attributing these effects in part due to possible GABAergic system modulation via interaction with GABA-A receptors.

While the use of sinomenine in higher doses has been explored as a potential sleep aid, Our Baicalm serving is formulated with intention to deliver the perfect amount for daily tranquility, stress reduction, and comfort.

Pillar 2: Wakeful Rest – Meditative Focus

> L-Theanine [Std. to ≥99% pure]

Present in small amounts in tea and mushrooms, L-theanine is credited for the sense of relaxed contentment and clarity of thought after drinking green tea.

In recent years, studies have continued to evaluate the calm-promoting and focus-inducing properties of this phytochemical. Research using electroencephalograph (EEG) found that consumption of L-theanine may significantly increase alpha wave brain activity, a wave frequency observed in the brain during meditation and in states of wakeful rest. One serving of BaiCalm contains the L-Theanine content of about 12 strong cups of green tea.

Pillar 3: Superior Bioavailability – An Advanced Calm Complex

> Curcumin [Standardized to ≥95% curcuminoid]
> Black Pepper Fruit Extract [≥95% Piperine]

Our R&D team set out with a goal to deliver the most effective baicalein complex on the market.

Key in this effort was the addition of synergistic ingredients to enhance its GABAergic properties, but we also needed to address some longstanding challenges with standalone baicalein extracts: delayed onset, and limited absorption due to low GI solubility and stability.

After a long developmental process, and the carefully balanced addition of curcumin and piperine, our BaiCalm complex contains the perfect delivery system, painstakingly formulated for ultimate bioavailability. Piperine is well known for its positive impact on metabolism, and its ability to significantly improve the absorption and uptake of many dietary supplements. In the specific case of curcumin, piperine increases bioavailability by up to 2000%. When paired with baicalein, research found curcumin to be even superior to piperine in potentially inhibiting glucuronidation in the lower intestine, resulting in superior baicalein absorption.

It is the effect of this three-step synergy (Piperine > Curcumin > Baicalein) we call our “Advanced Calm Complex”.

More than just an absorption aid, curcumin is also a potent antioxidant, neuroprotective, and a safe daily supplement for a myriad of health benefits. With a low molecular weight enabling passage through the blood-brain barrier, curcumin is capable of interacting with neurotransmitters such as serotonin, making it the subject of extensive research into its potential as a daily supplement to support calm and brighten one’s mood.

A safe natural polyphenol extracted from turmeric root, curcumin maximizes synergy, and is the finishing phytochemical touch to potentially enhance relaxation and promote a palpable sense of well-being

Instructions & Ingredients

DAILY SUPPORT: 1-2 capsules, up to two times per day. ACUTE USE: 3 to 4 capsules as needed, up to two times per day. Please start with the lowest dose to assess response. Can be taken with or without food (please be advised - effects may be more pronounced on an empty stomach).

Supplement Facts
Serving size: 2 capsules Servings per container: 4
Amount per serving % DV
Scutellaria Baicalensis Extract [std. ≥98% Baicalein] 256mg
Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol] 169mg
L-Theanine [Std. to ≥99% pure] 102mg
Curcumin [Standardized to ≥95% curcuminoid] 82mg
Sinomenium Acutum Stem Extract [Std. to ≥98% Sinomenine HCl] 41mg
Black Pepper Fruit Extract [≥95% Piperine] 10mg
‡ Daily Value not established.

Disclaimer & Other Info

The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

Regular price $3.68
Regular price $0.00 Sale price $3.68
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Scientifically Tailored Ingredients


  • Baicalein
  • Magnolia Bark Extract
  • L-Theanine
  • Curcumin
  • Sinomenium accutum Stem Extract
  • Piperine (Black Pepper Extract)
Baicalein
Baicalein

Baicalein

Baicalein is the primary active component from the Blue Skullcap plant (also known as Baikal Skullcap). • Calming and Stress-Reducing • Antioxidant and Immune Support • 5 - 10x Bioavailability Compared to Baicalin

Magnolia Bark Extract
Magnolia Bark Extract

Magnolia Bark Extract

Magnolia Bark Extract is an ingredient used in traditional medicine and dietary supplements, containing the beneficial ingredients Honokiol and Magnolol. In addition to their calming properties, Honokiol and Magnolol have numerous protective health benefits based on their antioxidant and brain-health supporting effects. - Calming & Relaxing - Antioxidant & Immune Support - Promotes Brain Health

L-Theanine
L-Theanine

L-Theanine

L-Theanine is a naturally occurring nutrient found in tea, and is used as an ingredient in dietary supplement products. Studies suggest that L-Theanine may help reduce mental and physical stress, improve cognition and boost mood. L-Theanine is unique in supporting a calm mood while at the same time enhancing a sense of clarity and focus. - Reduces Stress - Boosts Cognition - Calming

Curcumin
Curcumin

Curcumin

Curcuma longa (Turmeric) is a flowering plant which is a member of the ginger family. Turmeric powder is arguably one of the beneficial naturally occurring supplements. Some active compounds within Turmeric are called curcuminoids. The best known curcuminoid is Curcumin. - Supports a Positive Mood - Promotes Healthy Circulatory System

Sinomenium accutum Stem Extract
Sinomenium accutum Stem Extract

Sinomenium accutum Stem Extract

Sinomenine is the active compound in the roots of the *Sinomenium acutum* plant. As a herbal extract, Sinomenium acutum has been used traditionally for its neuroprotective properties. Research suggests it assists in increasing the influx of chloride into the cells of the hypothalamus – a small part of the brain that plays an important role in energy maintenance and in stress control. - Mood Lifting - Potent Neuroprotective Properties - Supports Immune Function

Piperine (Black Pepper Extract)
Piperine (Black Pepper Extract)

Piperine (Black Pepper Extract)

Piperine is an alkaloid extracted from black pepper and is typically used for its ability to inhibit the process of glucuronidation. This allows for significantly increased absorption of many types of dietary supplements. - Antioxidant Effects - Slows the Degradation of Polyphenols - Improves Ingredient Bioavailability

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References

Yoo JH, Ha TW, Hong JT, Oh KW. Sinomenine, an Alkaloid Derived from Sinomenium acutum Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep in Rodents. Biomol Ther (Seoul). 2017 Nov 1;25(6):586-592. doi: 10.4062/biomolther.2017.157. PMID: 29081090; PMCID: PMC5685427.

Bochoráková, H., Paulová, H., Slanina, J., Musil, P., Táborská, E. (2003). Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res, 17(6):640-4.

Wang, H., Hui, K.M., Chen, Y., Xu, S., Wong, J.T., Xue, H. (2002). Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to the benzodiazepine site of GABA(A) receptor complex. Planta Med, 68(12):1059-62.

Fong, Sophia & Li, Chen & Wo, SK & Wang, Shu & Zhou, Limin & Zhang, Li & Lin, Ge & Zuo, Zhong. (2011). In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of Baicalein. Journal of ethnopharmacology. 141. 742-53. 10.1016/j.jep.2011.08.042.

Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PMID: 18296328.

Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017 Oct 22;6(10):92. doi: 10.3390/foods6100092. PMID: 29065496; PMCID: PMC5664031.

Kulkarni SK, Dhir A. An overview of curcumin in neurological disorders. Indian J Pharm Sci. 2010 Mar;72(2):149-54. doi: 10.4103/0250-474X.65012. PMID: 20838516; PMCID: PMC2929771.