BaiCalm (Baicalein Complex) Sample

Containing an HPLC-verified, synergized stack of bioactive, GABAergic, tranquility-promoting plant extracts, Baicalm is an ‘Advanced Calm Complex’: masterfully formulated for superior bioavailability, delivering noticeable calm, and a heightened sense of well-being.

How it Works: Gabaergic compounds and nervous system regulation

The inhibitory signaling of GABA (γ-Aminobutyric acid) via binding and activation of GABA receptors is a key messaging system a healthy central nervous system could utilize potentially to reduce neuronal excitability and regulate emotions such as fear, panic, or intense stress. Developed via our three pillar methodology, the BaiCalm formula starts with a research-driven, synergized stack of potent, natural GABAergic compounds.

Pillar 1: GABAergic Synergy – 3 Calming Plant Extracts

> Scutellaria Baicalensis Extract [Std. to ≥98% Baicalein]

Baicalein (5,6,7-trihydroxyflavone) is a potent flavonoid from Skullcap (S. Baicalensis), with a long history of use in Traditional Chinese Medicine. 2-3x more bioavailable than baicalin, a wealth of studies have asserted strong GABAergic activity of baicalein via modulation of the brain’s benzodiazepine site of the GABA-A receptors. This subtle but noticeable downshift of neuronal response to ‘fight or flight’ supports serenity without sedation – so you can wind down without tuning out.

Not only a long-term LiftMode favorite for calming nerves, baicalein is a potent antioxidant and has been extensively researched for a myriad of other ways in which it can promote wellbeing – including activities as a neuroprotective, a promoter of circulatory health, and supporter of an upbeat and resilient mood – each potentially enabled by gentle downregulation of cytokine signaling throughout the brain and body.

> Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol]

Baicalm’s Magnolia Bark Extract (M. Officianalis), favored in TCM as a soothing relaxant, contains a ≥95% concentration of powerful bioactive neolignan constituents magnolol and honokiol. Synergizing with baicalein, these neuroprotective compounds have both been shown to enhance GABAergic neurotransmission, binding to and positively modulating GABA-A receptors.

Research continues to explore other positive effects of magnolol and honokiol, beyond their impact on mood-regulating serotonin receptors and stress-related catecholamines. Magnolia bark extract may continue to be a popular natural remedy for not only calming, but also as a supplement to enhance mood, reduce stress and support an overall sense of reassurance and wellbeing.

At LiftMode, we call it “the BaiCalm glow”.

> Sinomenium Accutum Extract [Std. to ≥98% Sinomenine HCL]

Extracts of the plant Sinomenium acutum have a long history of use in Japan, China and Korea as traditional medicine for stabilizing mood, easing discomfort and soothing various aches and pains. Only recently have researchers begun to explore this natural extract’s primary alkaloid (Sinomenine) and its relaxing and relieving properties, with animal trial results attributing these effects in part due to possible GABAergic system modulation via interaction with GABA-A receptors.

While the use of sinomenine in higher doses has been explored as a potential sleep aid, Our Baicalm serving is formulated with intention to deliver the perfect amount for daily tranquility, stress reduction, and comfort.

Pillar 2: Wakeful Rest – Meditative Focus

> L-Theanine [Std. to ≥99% pure]

Present in small amounts in tea and mushrooms, L-theanine is credited for the sense of relaxed contentment and clarity of thought after drinking green tea.

In recent years, studies have continued to evaluate the calm-promoting and focus-inducing properties of this phytochemical. Research using electroencephalograph (EEG) found that consumption of L-theanine may significantly increase alpha wave brain activity, a wave frequency observed in the brain during meditation and in states of wakeful rest. One serving of BaiCalm contains the L-Theanine content of about 12 strong cups of green tea.

Pillar 3: Superior Bioavailability – An Advanced Calm Complex

> Curcumin [Standardized to ≥95% curcuminoid]
> Black Pepper Fruit Extract [≥95% Piperine]

Our R&D team set out with a goal to deliver the most effective baicalein complex on the market.

Key in this effort was the addition of synergistic ingredients to enhance its GABAergic properties, but we also needed to address some longstanding challenges with standalone baicalein extracts: delayed onset, and limited absorption due to low GI solubility and stability.

After a long developmental process, and the carefully balanced addition of curcumin and piperine, our BaiCalm complex contains the perfect delivery system, painstakingly formulated for ultimate bioavailability. Piperine is well known for its positive impact on metabolism, and its ability to significantly improve the absorption and uptake of many dietary supplements. In the specific case of curcumin, piperine increases bioavailability by up to 2000%. When paired with baicalein, research found curcumin to be even superior to piperine in potentially inhibiting glucuronidation in the lower intestine, resulting in superior baicalein absorption.

It is the effect of this three-step synergy (Piperine > Curcumin > Baicalein) we call our “Advanced Calm Complex”.

More than just an absorption aid, curcumin is also a potent antioxidant, neuroprotective, and a safe daily supplement for a myriad of health benefits. With a low molecular weight enabling passage through the blood-brain barrier, curcumin is capable of interacting with neurotransmitters such as serotonin, making it the subject of extensive research into its potential as a daily supplement to support calm and brighten one’s mood.

A safe natural polyphenol extracted from turmeric root, curcumin maximizes synergy, and is the finishing phytochemical touch to potentially enhance relaxation and promote a palpable sense of well-being