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  • Reduces stress, boosts mood
  • Promotes deep, healthy restful sleep
  • Creates a feeling of well-being

Phenibut is a calming, mood lifting, sociability enhancing, and potentially (in low serving sizes) nootropic supplement that acts as a GABA-B agonist to ease stress and support a positive, social mood. Phenibut is one of the most effective and powerful amino acid supplements available. The primary benefits of Phenibut use also include pain-reduction, easing muscle tension and stress, and promotion of deep, restful sleep.The recommended serving size of Phenibut is 500 - 2000mg per day, depending on the desired effect.

Warning: Phenibut can be addictive when abused. Use caution when using regularly. Not for use by those under the age of 18! Phenibut should not be consumed in amounts exceeding 4 grams total per week, and should NEVER be taken in higher amounts on consecutive days, due to the risk of rapid tolerance to the benefits. Be sure to always carefully read and follow the Phenibut usage guidelines provided on the product container. Side effects of higher or excessive Phenibut consumption may include severe nausea, dizziness, vertigo, and lethargy; or after consumption of very high Phenibut doses, may also include prolonged sleep or stupor, with reduced responsiveness, which typically resolves within 36-48 hours. Withdrawal symptoms, including several days of anxiety, depression, and insomnia, can occur upon abrupt discontinuation after continuous excessive use. Phenibut requires careful, disciplined and responsible cycling and limited consumption in order to maximize its benefits and minimize the potential drawbacks.

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Phenibut Reviews



I've been taking a Phenibut from Liftmode for over 3 years now with excellent...mood-lifting results. As long as you are responsible and cycle on and off at a steady pattern, you will continue to see results. I would not consider buying this product from any other supplier.” – J Martin

Phenibut is GREAT for (mood lifting effects)... depending on dosage. In fact, it will eradicate fear from your mind while you are on it. Also great on weekends. I feel well rested on only 5-6 hours of sleep where during the week not even 8-9 hours can make me feel that way.” – Customer review, LiftMode Phenibut.


  • Phenibut is a nootropic substance that acts as a GABA agonist to treat stress... and promote restful sleep.


  • The primary effects of Phenibut use include pain-reduction, promoting calmness and a feeling of well-being, reduction of stress and promotion of restful sleep at higher doses.


  • Recommended dosage of phenibut is 500-2000mg per day, separated into two to three servings, and It is not recommended to exceed 2000mg daily or 1000mg per serving or to be used more than 2 times per week


  • Mild side effects may include dizziness and lethargy with higher doses and withdrawal symptoms are rare but can occur after prolonged use.




Phenibut, also known as β-Phenyl-γ-aminobutyric acid or noofen, has been used significantly in Russia since the 1960s as a nootropic supplement for supporting healthy stress levels, for supporting a feeling of well-being and positive, sociable mood, and to promote good restful sleep. GABA is the primary inhibitory neurotransmitter molecule in the brain, and GABA receptors are divided into three groups: GABA-A, -B, and –C.  Each GABA receptor type has different functions. Targeting GABA-A subtypes produces sedative, anxiolytic, muscle-relaxing, and alcohol-potentiating effects, as well as potential nootropic effects (for antagonists or negative allosteric modulators of GABA-A subtype 5).

Targeting GABA-B subtypes reduces pain signals, relieves muscle tension and spasticity, and in low or threshold amounts can have positive effects on memory, learning and mood. Phenibut (or fenibut / phenybut) acts primarily as a GABA-B agonist and in larger amounts may also play a role in activating some GABA-A receptors. Its use as a GABA agonist is important because it is often not efficient to supplement with GABA alone due to the chemical structure of the GABA molecule. The phenyl-group on Phenibut allows the chemical to cross the blood-brain barrier, while GABA itself cannot do this.  It should be noted that other commonly used substances are also GABA agonists, which include alcohol as well as commonly prescribed anti-anxiety and sleep-inducing compounds.[1]


Phenibut Effects & Benefits


GABA receptors are found throughout the CNS and specifically in regions of the spinal cord that are known to be associated with pain. The GABA receptors are also found outside of the spinal cord and in areas of the CNS that are known to coordinate the response to and perception of pain, as well as muscle tension and spasticity. GABA is an inhibitory neurotransmitter which acts to regulate (‘filter out’) the amount of information that reaches the CNS. In a very simplified explanation, GABA transmitters are able to modulate the perception of pain and since they are inhibitory, a greater concentration of GABA will inhibit the perception of pain and reduce muscle tension and spasticity. Since Phenibut acts as a GABA-B agonist, it is also able to reduce pain and muscle tension, along with other anxiolytic effects that include mood-lift and a calm sense of well-being, sometimes perceived as euphoria.[2]

GABA-B receptors are also being studied in the treatment of Autism and Asperger’s diseases, where the GABA-B receptor agonist arbaclofen showed some promise in enabling greater social function. Phenibut is sold as an amino acid supplement and is not intended to not intended to diagnose, treat, cure, or prevent any disease.

One benefit of Phenibut is that the serving size can be altered according to what effect is desired. For simple stress relief and mood lift, a lower serving size (closer to 500mg) is used. When the serving size is increased, Phenibut can begin to act more like a sedating or hypnotic (sleep-inducing) supplement.

The spectrum of effects at different serving sizes may emerge from the nature of GABA’s actions at various receptors, and the degree to which different concentrations of Phenibut serve to activate an increasing set of GABA receptors.  Activating different GABA-receptors subtypes have different effects on the human body. While GABA-B agonists have a strong potential to aid pain and stress relief, at higher serving sizes they may possibly begin to activate additional GABA-receptor groups, leading to sedating and sleep-promoting effects.

Often when we lie awake at night we are thinking about a lot of things and feeling a lot of things in our bodies and are generally restless. Phenibut is able to block out these perceptions and calm the mind to improve sleep quality.[3]

A lot of research has gone into the use of Phenibut as a neuroprotective agent, and it has been found to be able to protect the brain from stress, especially when the brain is deprived of oxygen, such as can occur during drowning, injury, or during extreme physical exertion which could cause overheating.

Phenibut has also been found to have profound cardioprotective effects, which include the potential to protect the heart from injury under stressful conditions.

Scientists have concluded from these studies that Phenibut results in higher cardiac contraction and relaxation rates, higher left-ventricular pressure during functional tests, and increased indexes of oxidative phosphorylation.”[4]


Phenibut Recommended Usage


The recommended serving size of Phenibut is 500-2000mg per day, in two to three separate servings, and NEVER more than 4 grams (4000mg) total per week. Phenibut is best used when taken only if needed for a specific purpose, or cycled and taken not more than two days per week. A lower Phenibut serving size usually encourages mood-lift, stress relief, sociability and motivation, whereas in higher doses, Phenibut acts more as a sedating supplement and results in better, deeper sleep. It is strongly recommended NOT to exceed the daily or weekly maximum recommended consumption of Phenibut, as negative effects can occur when too much Phenibut is consumed. 


Phenibut Side Effects and Warnings


Phenibut is for many people an extremely useful supplement with multiple calming and mood-enhancing effects - but, as with all GABA agonists, it can have notable side effects, especially if not used with respect and caution.

LiftMode makes Phenibut available because we believe that the helpful and life enhancing effects of Phenibut when used properly, can outweigh the negative effects when Phenibut is used improperly.  We strongly urge anyone thinking of supplementing with Phenibut to consult with their doctor or trusted healthcare professional, to use the minimum dosage of Phenibut that produces the desired benefits, and never to exceed the maximum recommended amounts, or combine Phenibut with other medications that affect mood or alertness. 

Phenibut’s side effects when taken within the recommended serving sizes are generally mild or manageable, but can include gastrointestinal issues, dizziness, tiredness, memory reduction and lethargy, which are common with the use of various GABA-agonists.[5]

Withdrawal effects from Phenibut use have also frequently been reported. For this reason, when discontinuing Phenibut, it is recommended to steadily reduce dosage of Phenibut before stopping entirely.  Stopping Phenibut consumption abruptly, especially if taking Phenibut near or above the maximum recommended amounts, can cause negative withdrawal symptoms.  Phenibut withdrawal effects can include negative thoughts, depression, lethargy, prolonged insomnia, persistent restlessness, stress and panic attacks. There is a reported case of a 25-year old man in Russia who became hospitalised for psychosis from withdrawal after long high-dose use of Phenibut.[6] The man was consuming a Phenibut dose of 20 grams of Phenibut per day, which is a huge amount and creates massive risks of overdosing and withdrawal, as well as placing stress on the liver. The symptoms he experienced had some similarities to alcohol-dependant withdrawal as well as withdrawal from Baclofen, GHB, and benzodiazepines which are also GABA agonists.

“Phenibut should NEVER be taken with benzodiazepenes, opioids or alcohol as these combinations may result in respiratory depression that may lead to unconsciousness or even death”.



[1] “Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug” Izyaslav Lapin, CNS Drug Reviews, Volume 7, Issue 4,  pages 471–481, December 2001

[2] “The role of GABA in the mediation and perception of pain” Enna SJ1, McCarson KE, PubMed, Adv Pharmacol. 2006;54:1-27.

[3] “Take Phenibut For an Alternative Source of Anxiety Relief”, Nootropic Mind, online article, April 5 2014

[4] “The Science of Phenibut”, Phenibut for Anxiety, online article, 2012

[5] “Phenibut, the Appearance of Another Potentially Dangerous Product in the United States” Charles W. O’Connell, MD, Aaron B. Schneir, MD, James Q. Hwang, MD, MPH, F. Lee Cantrell, PharmD, The American Journal of Medicine, August 2014

[6] “Psychotic symptoms during Phenibut (beta-phenyl-gamma-aminobutyric acid) withdrawal”, Lovisa Högberg, István Szabó, and Jaan Ruusa, Journal of Substance Use, 2013, Vol. 18, No. 4 , Pages 335-338



Phenibut is an effective calming supplement related to GABA, with increased bioavailability, which helps ease and reduce stress and tension. Phenibut also supports a positive, uplifted and outgoing mood. In addition, Phenibut helps support a deep, restful night's sleep, and moderate amounts of Phenibut can be used like GABA to increase flexibility and enhance muscle growth.

Phenibut was originally developed as an over the counter anxiolytic in Russia, which does not impair performance or focus, but prevents nervousness; and Phenibut was so trusted that it was selected as a supplement for the Cosmonaut program, so that astronauts could operate effectively with a clear head under pressure.

LiftMode Phenibut products include 40 grams, 100 grams, 200 grams, and 500 grams of the purest Phenibut HCl crystals available on the market. Unlike other brands or sources, LiftMode never adds any fillers or inactive ingredients to its 99.8+% pure Phenibut. LiftMode packages our Phenibut in sturdy, convenient, and airtight polypropylene jars along with the correct scoops, to ensure easy measurement, and fresh Phenibut with a long shelf life. In addition to offering the best quality Phenibut crystal granules, LiftMode is also the exclusive source for Phenibut FAA (free amino acid), which is the non-acidic form of Phenibut that is optimum for sublingual administration.

You might also be interested in our other nootropics like Choline Bitartrate or Huperzine A.